Supplementary data for "Cholesterol modulates glycolipid conformation and receptor activity"

  • Daniel Lingwood (Creator)
  • Michal Grzybek (Creator)
  • Ünal Coskun (Creator)
  • Kai Simons (Creator)
  • Beth Binnington (Creator)
  • Clifford Lingwood (Creator)
  • Tomasz Rog (Creator)
  • Ilpo Vattulainen (Creator)



    We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid 'allostery' is a means to regulate membrane recognition processes.
    Date made available2017
    PublisherTampere University of Technology

    Cite this