Supplementary Material for: Association of Torquetenovirus viremia with physical frailty and cognitive impairment in three independent European cohorts

  • Robertina Giacconi (Contributor)
  • Blanca Laffon (University of La Coruña (UDC), Instituto de Investigación Biomédica de A Coruña (INIBIC) (Contributor)
  • S Costa (Contributor)
  • Ana I. Teixeira (Contributor)
  • F Maggi (Contributor)
  • L Macera (Contributor)
  • PG Spezia (Contributor)
  • Francesco Piacenza (Contributor)
  • Alexander Bürkle (Contributor)
  • María Moreno-Villanueva (University of Konstanz) (Contributor)
  • Stefano Bonassi (IRCCS San Raffaele Pisana, San Raffaele University) (Contributor)
  • Vanessa Valdiglesias (Instituto de Investigación Biomédica de A Coruña (INIBIC), University of La Coruña (UDC) (Contributor)
  • J. Teixeira (Contributor)
  • M. E.T. Dollé (Contributor)
  • M. Liset Rietman (National Institute for Public Health and the Environment) (Contributor)
  • Eugène Jansen (National Institute for Public Health and the Environment) (Contributor)
  • Tilman Grune (Contributor)
  • Efstathios S Gonos (Contributor)
  • Claudio Franceschi (Contributor)
  • Miriam Capri (Contributor)
  • B Weinberger (Contributor)
  • Ewa Sikora (Contributor)
  • Wolfgang Stuetz (Contributor)
  • Olivier Toussaint (Contributor)
  • Florence Debacq-Chainiaux (Contributor)
  • Antti Hervonen (Creator)
  • Mikko Hurme (Creator)
  • P. Eline Slagboom (Contributor)
  • Christiane Schön (Contributor)
  • Jürgen Bernhardt (Contributor)
  • Nicolle Breusing (Contributor)
  • Eduardo Pásaro (University of La Coruña (UDC), Instituto de Investigación Biomédica de A Coruña (INIBIC) (Contributor)
  • Ana Maseda (University of La Coruña (UDC) (Contributor)
  • J L. Lorenzo (Contributor)
  • J Millán (Contributor)
  • Mauro Provinciali (Contributor)
  • Marco Malavolta (Contributor)



Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population. The objective of this study was to analyze the relation between TTV viremia, physical frailty and cognitive impairment Methods: TTV viremia was measured in 1131 nonfrail, 45 physically frail, and 113 cognitively impaired older adults recruited in the MARK-AGE study (overall mean age 64.7±5.9 years), then the results were checked in two other independent cohorts from Spain and Portugal, including 126 frail, 252 prefrail and 141 nonfrail individuals (overall mean age: 77.5±8.3 years). Results: TTV viremia ≥4log was associated with physical frailty (OR: 4.69; 95% CI: 2.06-10.67, p
Date made available10 Jan 2023

Field of science, Statistics Finland

  • 3121 Internal medicine
  • Association of Torquetenovirus Viremia with Physical Frailty and Cognitive Impairment in Three Independent European Cohorts

    Giacconi, R., Laffon, B., Costa, S., Teixeira-Gomes, A., Maggi, F., MacEra, L., Spezia, P. G., Piacenza, F., Bürkle, A., Moreno-Villanueva, M., Bonassi, S., Valdiglesias, V., Teixeira, J. P., Dollé, M. E. T., Rietman, M. L., Jansen, E., Grune, T., Gonos, E. S., Franceschi, C., Capri, M., & 17 othersWeinberger, B., Sikora, E., Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Hervonen, A., Hurme, M., Slagboom, P. E., Schön, C., Bernhardt, J., Breusing, N., Pásaro, E., Maseda, A., Lorenzo-López, L., Millán-Calenti, J. C., Provinciali, M. & Malavolta, M., 2023, In: GERONTOLOGY. 69, 6, p. 684-693 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

    3 Citations (Scopus)

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