Supplementary Material for: Association of Torquetenovirus viremia with physical frailty and cognitive impairment in three independent European cohorts

  • Robertina Giacconi (Contributor)
  • Blanca Laffon (Contributor)
  • S Costa (Contributor)
  • Ana I. Teixeira (Contributor)
  • F Maggi (Contributor)
  • L Macera (Contributor)
  • PG Spezia (Contributor)
  • Francesco Piacenza (Contributor)
  • Alexander Bürkle (Contributor)
  • Maria Moreno-Villanueva (Contributor)
  • Stefano Bonassi (Contributor)
  • Vanessa Valdiglesias (Contributor)
  • J. Teixeira (Contributor)
  • M. E.T. Dollé (Contributor)
  • M. Liset Rietman (Contributor)
  • Eugene H.J.M. Jansen (Contributor)
  • Tilman Grune (Contributor)
  • Efstathios S Gonos (Contributor)
  • Claudio Franceschi (Contributor)
  • Miriam Capri (Contributor)
  • B Weinberger (Contributor)
  • Ewa Sikora (Contributor)
  • Wolfgang Stuetz (Contributor)
  • Olivier Toussaint (Contributor)
  • Florence Debacq-Chainiaux (Contributor)
  • Antti Hervonen (Creator)
  • Mikko Hurme (Creator)
  • P. Eline Slagboom (Contributor)
  • Christiane Schön (Contributor)
  • Jürgen Bernhardt (Contributor)
  • Nicolle Breusing (Contributor)
  • Eduardo Pásaro (Contributor)
  • Ana Maseda (Contributor)
  • J L. Lorenzo (Contributor)
  • J Millán (Contributor)
  • Mauro Provinciali (Contributor)
  • Marco Malavolta (Contributor)

Dataset

Description

Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population. The objective of this study was to analyze the relation between TTV viremia, physical frailty and cognitive impairment Methods: TTV viremia was measured in 1131 nonfrail, 45 physically frail, and 113 cognitively impaired older adults recruited in the MARK-AGE study (overall mean age 64.7±5.9 years), then the results were checked in two other independent cohorts from Spain and Portugal, including 126 frail, 252 prefrail and 141 nonfrail individuals (overall mean age: 77.5±8.3 years). Results: TTV viremia ≥4log was associated with physical frailty (OR: 4.69; 95% CI: 2.06-10.67, p
Date made available10 Jan 2023
Publisherfigshare

Field of science, Statistics Finland

  • 3121 Internal medicine

  • Association of Torquetenovirus Viremia with Physical Frailty and Cognitive Impairment in Three Independent European Cohorts

    Giacconi, R., Laffon, B., Costa, S., Teixeira-Gomes, A., Maggi, F., MacEra, L., Spezia, P. G., Piacenza, F., Bürkle, A., Moreno-Villanueva, M., Bonassi, S., Valdiglesias, V., Teixeira, J. P., Dollé, M. E. T., Rietman, M. L., Jansen, E., Grune, T., Gonos, E. S., Franceschi, C. & Capri, M. & 17 others, Weinberger, B., Sikora, E., Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Hervonen, A., Hurme, M., Slagboom, P. E., Schön, C., Bernhardt, J., Breusing, N., Pásaro, E., Maseda, A., Lorenzo-López, L., Millán-Calenti, J. C., Provinciali, M. & Malavolta, M., 2023, In: GERONTOLOGY. 69, 6, p. 684-693 10 p.

    Research output: Contribution to journal › Article › Scientific › peer-review

    7 Citations (Scopus)

Cite this