Research output per year
Research output per year
- 46 results
Search results
-
2024
Gellan gum-gelatin based cardiac models support formation of cellular networks and functional cardiomyocytes
Vuorenpää, H., Valtonen, J., Penttinen, K., Koskimäki, S., Hovinen, E., Ahola, A., Gering, C., Parraga, J., Kelloniemi, M., Hyttinen, J., Kellomäki, M., Aalto-Setälä, K., Miettinen, S. & Pekkanen-Mattila, M., 2024, In: CYTOTECHNOLOGY. 76, p. 483-502 20 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile5 Citations (Scopus)18 Downloads (Pure) -
2023
Coronary artery disease patient-derived iPSC-hepatocytes have distinct miRNA profile that may alter lipid metabolism
Alexanova, A., Raitoharju, E., Valtonen, J., Aalto-Setälä, K. & Viiri, L. E., Jan 2023, In: Scientific Reports. 13, 13 p., 1706.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile2 Citations (Scopus)20 Downloads (Pure) -
Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays
Maria Cherian, R., Prajapati, C., Penttinen, K., Häkli, M., Koivisto, J. T., Pekkanen-Mattila, M. & Aalto-Setälä, K., 2023, In: CELL BIOLOGY AND TOXICOLOGY. 39, 1, p. 145–163 19 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile2 Citations (Scopus)35 Downloads (Pure) -
HiPSC-derived cardiomyocyte to model Brugada syndrome: both asymptomatic and symptomatic mutation carriers reveal increased arrhythmogenicity
Penttinen, K., Prajapati, C., Shah, D., Rajan, D. K., Cherian, R. M., Swan, H. & Aalto-Setälä, K., 25 Apr 2023, In: BMC Cardiovascular Disorders. 23, 17 p., 208.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile3 Citations (Scopus)17 Downloads (Pure) -
The Junctophilin-2 Mutation p.(Thr161Lys) Is Associated with Hypertrophic Cardiomyopathy Using Patient-Specific iPS Cardiomyocytes and Demonstrates Prolonged Action Potential and Increased Arrhythmogenicity
Valtonen, J., Prajapati, C., Cherian, R. M., Vanninen, S., Ojala, M., Leivo, K., Heliö, T., Koskenvuo, J. & Aalto-Setälä, K., 27 May 2023, In: BIOMEDICINES. 11, 6, 19 p., 1558.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile6 Citations (Scopus)17 Downloads (Pure) -
2022
A method to measure data complexity of a complicated medical data set
Juhola, M., Joutsijoki, H., Penttinen, K., Shah, D. & Aalto-Setälä, K., Nov 2022, In: International Journal of Imaging Systems and Technology. 32, 6, p. 1822-1831 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile2 Citations (Scopus)22 Downloads (Pure) -
Cardiac Ischemia On-a-Chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Gaballah, M., Penttinen, K., Kreutzer, J., Mäki, A. J., Kallio, P. & Aalto-Setälä, K., Mar 2022, In: Cells. 11, 6, 21 p., 1045.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile13 Citations (Scopus)31 Downloads (Pure) -
Electrophysiological Changes of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes during Acute Hypoxia and Reoxygenation
Häkli, M., Kreutzer, J., Mäki, A.-J., Välimäki, H., Cherian, R. M., Kallio, P., Aalto-Setälä, K. & Pekkanen-Mattila, M., Dec 2022, In: Stem Cells International. 2022, 15 p., 9438281.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile8 Citations (Scopus)23 Downloads (Pure) -
Toward Xeno-Free Differentiation of Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells
Saari, J., Siddique, F., Korpela, S., Mäntylä, E., Ihalainen, T. O., Kaukinen, K., Aalto-Setälä, K., Lindfors, K. & Juuti-Uusitalo, K., Jan 2022, In: International Journal of Molecular Sciences. 23, 3, 1312.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile2 Citations (Scopus)42 Downloads (Pure) -
2021
Analysis of drug effects on iPSC cardiomyocytes with machine learning
Juhola, M., Penttinen, K., Joutsijoki, H. & Aalto-Setälä, K., 2021, In: Annals of Biomedical Engineering. 49, 2021:1, p. 129-138 32367466.Research output: Contribution to journal › Article › Scientific › peer-review
38 Citations (Scopus) -
Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods
Prajapati, C., Ojala, M., Lappi, H., Aalto-Setälä, K. & Pekkanen-Mattila, M., Mar 2021, In: Stem Cell Research. 51, 102176.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile10 Citations (Scopus)18 Downloads (Pure) -
Human induced pluripotent stem cell-based platform for modeling cardiac ischemia
Häkli, M., Kreutzer, J., Mäki, A. J., Välimäki, H., Lappi, H., Huhtala, H., Kallio, P., Aalto-Setälä, K. & Pekkanen-Mattila, M., 2021, In: Scientific Reports. 11, 1, 4153.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile33 Citations (Scopus)25 Downloads (Pure) -
On computational classification of genetic cardiac diseases applying iPSC cardiomyocytes
Juhola, M., Joutsijoki, H., Penttinen, K., Shah, D. & Aalto-Setälä, K., 2021, In: Computer Methods and Programs in Biomedicine. 210, 106367.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile5 Citations (Scopus)18 Downloads (Pure) -
2020
Co-culture of human induced pluripotent stem cell-derived retinal pigment epithelial cells and endothelial cells on double collagen-coated honeycomb films
Rebelo Calejo, T., Saari, J., Vuorenpää, H., Vuorimaa-Laukkanen, E., Kallio, P., Aalto-Setälä, K., Miettinen, S., Skottman, H., Kellomäki, M. & Juuti-Uusitalo, K., 2020, In: Acta Biomaterialia. 101, p. 327-343 17 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile22 Citations (Scopus)42 Downloads (Pure) -
hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells
Shah, D., Prajapati, C., Penttinen, K., Maria Cherian, R., Koivumäki, J. T., Alexanova, A., Hyttinen, J. & Aalto-Setälä, K., 2020, In: Cells. 9, 5, p. 1153 1153.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile22 Citations (Scopus)27 Downloads (Pure) -
Mutation-specific differences in arrhythmias and drug responses in CPVT patients: simultaneous patch clamp and video imaging of iPSC derived cardiomyocytes
Pölönen, R.-P., Swan, H. & Aalto-Setälä, K., 2020, In: MOLECULAR BIOLOGY REPORTS. 47, 2, p. 1067-1077Research output: Contribution to journal › Article › Scientific › peer-review
22 Citations (Scopus) -
2019
A Quantitative Comparison of 12-Lead Electrocardiograms and In Vitro Field Potentials of Stem Cell-Derived Cardiomyocytes
Vanninen, S., Kujala, V., Pörsti, I. & Aalto-Setälä, K., 2019, In: International Journal of Stem Cell Research & Therapeutics. 1, 1, p. 20-27Research output: Contribution to journal › Article › Scientific › peer-review
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Compromised barrier function in human induced pluripotent stem-cell-derived retinal pigment epithelial cells from type 2 diabetic patients
Kiamehr, M., Klettner, A., Richert, E., Koskela, A., Koistinen, A., Skottman, H., Kaarniranta, K., Aalto-Setälä, K. & Juuti-Uusitalo, K., 2019, In: International Journal of Molecular Sciences. 20, 15, 3773.Research output: Contribution to journal › Article › Scientific › peer-review
37 Citations (Scopus) -
Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles
Kiamehr, M., Heiskanen, L., Laufer, T., Düsterloh, A., Kahraman, M., Käkelä, R., Laaksonen, R. & Aalto-Setälä, K., 2019, In: International Journal of Molecular Sciences. 20, 12, p. E2910 2910.Research output: Contribution to journal › Article › Scientific › peer-review
30 Citations (Scopus) -
Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation
Viiri, L. E., Rantapero, T., Kiamehr, M., Alexanova, A., Oittinen, M., Viiri, K., Niskanen, H., Nykter, M., Kaikkonen, M. U. & Aalto-Setälä, K., 2019, In: Scientific reports. 9, 1, p. 3562 3562.Research output: Contribution to journal › Article › Scientific › peer-review
14 Citations (Scopus) -
hiPSC-derived hepatocytes closely mimic the lipid profile of primary hepatocytes: A future personalised cell model for studying the lipid metabolism of the liver
Kiamehr, M., Alexanova, A., Viiri, L. E., Heiskanen, L., Vihervaara, T., Kauhanen, D., Ekroos, K., Laaksonen, R., Käkelä, R. & Aalto-Setälä, K., 2019, In: Journal of Cellular Physiology. 234, 4, p. 3744-3761Research output: Contribution to journal › Article › Scientific › peer-review
18 Citations (Scopus) -
Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells
Shah, D., Virtanen, L., Prajapati, C., Kiamehr, M., Gullmets, J., West, G., Kreutzer, J., Pekkanen-Mattila, M., Heliö, T., Kallio, P., Taimen, P. & Aalto-Setälä, K., 2019, In: Cells. 8, 6, p. 594 594.Research output: Contribution to journal › Article › Scientific › peer-review
50 Citations (Scopus) -
On the separation of normal and abnormal stem cell-derived cardiomyocytes' calcium transient signals
Juhola, M., Joutsijoki, H., Varpa, K., Penttinen, K. & Aalto-Setälä, K., 2019, In: International Journal of Extreme Automation and Connectivity in Healthcare (IJEACH). 1, 2, p. 22-37Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile23 Downloads (Pure) -
Polyethylene Terephthalate Textiles Enhance the Structural Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Pekkanen-Mattila, M., Häkli, M., Pölönen, R., Mansikkala, T., Junnila, A., Talvitie, E., Koivisto, J., Kellomäki, M. & Aalto-Setälä, K., 2019, In: Materials. 12, 11, p. E1805 16 p., 1805.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile20 Citations (Scopus)25 Downloads (Pure) -
Screening of Hydrogels for Human Pluripotent Stem Cell–Derived Neural Cells: Hyaluronan‐Polyvinyl Alcohol‐Collagen‐Based Interpenetrating Polymer Network Provides an Improved Hydrogel Scaffold
Ylä‐Outinen, L., Harju, V., Joki, T., Koivisto, J. T., Karvinen, J., Kellomäki, M. & Narkilahti, S., 2019, In: MACROMOLECULAR BIOSCIENCE. 19, 7, 13 p., 1900096.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile21 Citations (Scopus)88 Downloads (Pure) -
2018
Automatic optimization of an in silico model of human iPSC derived cardiomyocytes recapitulating calcium handling abnormalities
Paci, M., Pölönen, R., Cori, D., Penttinen, K., Aalto-Setälä, K., Severi, S. & Hyttinen, J., 2018, In: Frontiers in Physiology. 9, JUN, p. 709 709.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile60 Citations (Scopus)32 Downloads (Pure) -
Divergent effects of adrenaline in human induced pluripotent stem cell-derived cardiomyocytes obtained from hypertrophic cardiomyopathy
Prajapati, C., Ojala, M. & Aalto-Setälä, K., 2018, In: Disease Models & Mechanisms. 26, 2, p. 2 dmm032896.Research output: Contribution to journal › Article › Scientific › peer-review
20 Citations (Scopus) -
Simultaneous Measurement of Contraction and Calcium Transients in Stem Cell Derived Cardiomyocytes
Ahola, A., Pölönen, R.-P., Aalto-Setälä, K. & Hyttinen, J., 2018, In: Annals of Biomedical Engineering. 46, 1, p. 148–158Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile43 Citations (Scopus)54 Downloads (Pure) -
Simultaneous recordings of action potentials and calcium transients from human induced pluripotent stem cell derived cardiomyocytes
Prajapati, C., Pölönen, R.-P. & Aalto-Setälä, K., 2018, In: Biology Open. 7, 7, p. bio035030 bio035030.Research output: Contribution to journal › Article › Scientific › peer-review
18 Citations (Scopus) -
2017
Lipidomic profiling of patient-specific iPSC-derived hepatocyte-like cells
Kiamehr, M., Viiri, L., Vihervaara, T., Koistinen, K., Hilvo, M., Kim, E., Ekroos, K., Käkelä, R. & Aalto-Setälä, K., 2017, In: Disease Models & Mechanisms. 10, 9, p. 1141-53Research output: Contribution to journal › Article › Scientific › peer-review
24 Citations (Scopus) -
Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes
Kuusela, J., Larsson, K., Shah, D., Prajapati, C. & Aalto-Setälä, K., 2017, In: Biology Open. 6, 6, p. 777-784Research output: Contribution to journal › Article › Scientific › peer-review
15 Citations (Scopus) -
Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct
Vuorenpää, H., Penttinen, K., Heinonen, T., Pekkanen-Mattila, M., Sarkanen, J.-R., Ylikomi, T. & Aato-Setälä, K., 2017, In: Cytotechnology. 96, 5, p. 785-800 16 p.Research output: Contribution to journal › Article › Scientific › peer-review
25 Citations (Scopus) -
2016
Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes
Kuusela, J., Kujala, V. J., Kiviaho, A., Ojala, M., Swan, H., Kontula, K. & Aalto-Setälä, K., 2016, In: SpringerPlus. 5, 1, p. 234 234.Research output: Contribution to journal › Article › Scientific › peer-review
23 Citations (Scopus) -
Error-Correcting Output Codes in Classification of Human Induced Pluripotent Stem Cell Colony Images
Joutsijoki, H., Haponen, M., Rasku, J., Aalto-Setälä, K. & Juhola, M., 2016, In: BioMed Research International. 2016, 2016, 3025057.Research output: Contribution to journal › Article › Scientific › peer-review
23 Citations (Scopus) -
Machine Learning Approach to Automated Quality Identification of Human Induced Pluripotent Stem Cell Colony Images
Joutsijoki, H., Haponen, M., Rasku, J., Aalto-Setälä, K. & Juhola, M., 2016, In: Computational and Mathematical Methods in Medicine. 2016, 3091039.Research output: Contribution to journal › Article › Scientific › peer-review
40 Citations (Scopus) -
Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or ?-Tropomyosin Mutation for Hypertrophic Cardiomyopathy
Ojala, M., Prajapati, C., Pölönen, R.-P., Rajala, K., Pekkanen-Mattila, M., Rasku, J., Larsson, K. & Aalto-Setälä, K., 2016, In: Stem Cells International. 2016, p. 1684792 1684792.Research output: Contribution to journal › Article › Scientific › peer-review
76 Citations (Scopus) -
2015
A Comparative View on Easy to Deploy non-Integrating Methods for Patient-Specific iPSC Production
Manzini, S., Viiri, L. E., Marttila, S. & Aalto-Setälä, K., 2015, In: Stem Cell Reviews and Reports. 11, 6, p. 900-908 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
26 Citations (Scopus) -
Antiarrhythmic effects of dantrolene in patients with catecholaminergic polymorphic ventricular tachycardia and replication of the responses using iPSC models
Penttinen, K., Swan, H., Vanninen, S., Paavola, J., Lahtinen, A. M., Kontula, K. & Aalto-Setälä, K., 2015, In: PLoS One. 10, 5, p. e0125366 e0125366.Research output: Contribution to journal › Article › Scientific › peer-review
84 Citations (Scopus) -
Methods for in vitro functional analysis of iPSC derived cardiomyocytes — Special focus on analyzing the mechanical beating behavior
Laurila, E., Ahola, A., Hyttinen, J. & Aalto-Setälä, K., 2015, In: Biochimica et Biophysica Acta: Molecular Cell Research. 1863, 7 Pt B, p. 1864-72Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile48 Citations (Scopus)139 Downloads (Pure) -
Novel analysis software for detecting and classifying Ca2+ transient abnormalities in stem cell-derived cardiomyocytes
Penttinen, K., Siirtola, H., Àvalos-Salguero, J., Vainio, T., Juhola, M. & Aalto-Setälä, K., 2015, In: PLoS ONE. 10, 8, p. e0135806 e0135806.Research output: Contribution to journal › Article › Scientific › peer-review
10 Citations (Scopus) -
Signal analysis and classification methods for the calcium transient data of stem cell-derived cardiomyocytes
Juhola, M., Penttinen, K., Joutsijoki, H., Varpa, K., Saarikoski, J., Rasku, J., Siirtola, H., Iltanen, K., Laurikkala, J., Hyyrö, H., Hyttinen, J. & Aalto-Setälä, K., 2015, In: Computers in Biology and Medicine. 61, p. 1-7 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
22 Citations (Scopus) -
2014
Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia
Spencer, C. I., Baba, S., Nakamura, K., Hua, E. A., Sears, M. A. F., Fu, C. C., Zhang, J., Balijepalli, S., Tomoda, K., Hayashi, Y., Lizarraga, P., Wojciak, J., Scheinman, M. M., Aalto-Setälä, K., Makielski, J. C., January, C. T., Healy, K. E., Kamp, T. J., Yamanaka, S. & Conklin, B. R., 2014, In: Stem Cell Reports. 3, 2, p. 269-281 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
103 Citations (Scopus) -
2012
Culture Conditions Affect Cardiac Differentiation Potential of Human Pluripotent Stem Cells
Ojala, M., Rajala, K., Pekkanen-Mattila, M., Miettinen, M., Huhtala, H. & Aalto-Setälä, K., 2012, In: PLoS ONE. 7, 10, p. e0048659 e48659.Research output: Contribution to journal › Article › Scientific › peer-review
32 Citations (Scopus) -
Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture
Lahti, A. L., Kujala, V. J., Chapman, H., Koivisto, A.-P., Pekkanen-Mattila, M., Kerkelä, E., Hyttinen, J., Kontula, K., Svan, H., Conklin, B. R., Yamanaka, S., Silvennoinen, O. & Aalto-Setälä, K., 2012, In: Disease Models & Mechanisms. 5, 2, p. 1-11 11 p., 008409.Research output: Contribution to journal › Article › Scientific › peer-review
246 Citations (Scopus) -
The effect of human and mouse fibroblast feeder cells on cardiac differentiation of human pluripotent stem cells
Pekkanen-Mattila, M., Ojala, M., Kerkelä, E., Rajala, K., Skottman, H. & Aalto-Setälä, K., 2012, In: Stem Cells International. 2012, p. 875059 875059.Research output: Contribution to journal › Article › Scientific › peer-review
20 Citations (Scopus) -
2011
Uudelleen ohjelmoidut iPS-kantasolut: Ihon fibroblasteista sydänsolumalliksi pitkä QT -oireyhtymälle
Lahti, A. & Aalto-Setälä, K., 2011, In: Solubiologi. 29, 1, p. 6-16Research output: Contribution to journal › Article › Scientific