Faculty of Medicine and Health Technology

Research output

Research output per year 1996 2019 2020 2021 2022 2023 2023

• 4755 Article
• 701 Conference contribution
• 393 Review Article
• 282 Doctoral thesis
• 819 More
  • 240 Chapter
  • 153 Abstract
  • 109 Comment/debate
  • 88 Editorial
  • 66 Letter
  • 42 Meeting Abstract
  • 23 Poster
  • 21 Commissioned report
  • 20 Anthology
  • 14 Patent
  • 7 Book
  • 7 Digital or Visual Products
  • 6 Preprint
  • 5 Data article
  • 4 Other contribution
  • 3 Other conference contribution
  • 2 Licentiate thesis
  • 2 Master's thesis
  • 2 Conference article
  • 1 Foreword/postscript
  • 1 Other online publication
  • 1 Special issue
  • 1 Web publication/site
  • 1 Working paper

Research output per year

Research output per year

Search results

• 2023

  Computational modeling of neuron-astrocyte interactions in large neural populations using the NEST simulator

  Acimovic, J., Jiang, H-J., Manninen, T., Stapmanns, J., Lehtimäki, M., Linne, M-L., Diesmann, M. & van Albada, S., 2023, In: Journal of Computational Neuroscience.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access
• 2021

  Astrocytic modulation of cortical synaptic plasticity: Integrating biological knowledge and computational modeling

  Manninen, T., Saudargiene, A. & Linne, M-L., 2021, In: Glia. 69, S1, T09-083E.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Combined exposure to vapors, gases, dusts, fumes and tobacco smoke increases the risk of asthma symptoms

  Hisinger-Molkanen, H., Pallasaho, P., Sovijarvi, A., Tuomisto, L., Andersen, H., Lindqvist, A., Backman, H., Langhammer, A., Ronmark, E., Lundback, B., Ilmarinen, P., Kankaanranta, H. & Piirila, P., Nov 2021, In: THORAX. 76, p. A96-A96 1 p.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review
• 2020

  Astrocyte simulations with realistic morphologies reveal diverse calcium transients in soma and processes

  Seppälä, I., Keto, L., Ahokainen, I., Förster, N., Manninen, T. & Linne, M-L., 2020, In: BMC Neuroscience. 21, Suppl 1, p. 67-68 1 p., P116.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access

• Morphologically‐detailed reconstruction of cerebellar glial cells

  Keto, L. & Manninen, T., 2020, In: BMC Neuroscience. 21, Suppl 1, p. 72 1 p., P124.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access

• The interplay of neural mechanisms regulates spontaneous cortical network activity: inferring the role of key mechanisms using data-driven modeling

  Acimovic, J., Manninen, T., Teppola, H. & Linne, M-L., 2020, In: BMC Neuroscience. 21, Suppl 1, p. 68 1 p., P117.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access
• 2019

  Modeling the influence of neuron-astrocyte interactions on signal transmission in neuronal networks

  Acimovic, J., Manninen, T., Teppola, H., van Albada, S., Diesmann, M. & Linne, M-L., 2019, In: BMC Neuroscience. 20, Suppl 1, p. 97 1 p., P178.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access
• 2018

  [P015] Contrast of dual energy CT in carotid artery analysis, a phantom study

  Caetano Dos Santos, F., Eskola, H., Christiani, R. & Laarne, P., 2018, In: Physica Medica. p. 102-103

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access

• A cellular disease model system of ARB: The creation of iPS-RPE from a patient with a premature stop mutation (p.R200X)

  Nommiste, B., Korkka, I., Radeke, M. J., Nymark, S., Coeffey, P. J. & Carr, A-J., Jul 2018, In: Investigative Ophthalmology and Visual Science. 59, 5313

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Computational modeling of neuron-astrocyte interactions: Evolution, reproducibility, comparability and future development of models

  Manninen, T., Saudargiene, A., Havela, R. & Linne, M-L., 2018, In: BMC Neuroscience. 19, Suppl 2, p. 68-68

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access

  • Astrocytes 100%
  • Neurons 66%
  • Electronic Data Processing 12%
  • Synapses 11%
  • Publications 10%

• Data-driven study of synchronous population activity in generic spiking neuronal networks: How much do we capture using the minimal model for the considered phenomena?

  Acimovic, J., Teppola, H., Mäki-Marttunen, T. M. & Linne, M-L., 29 Oct 2018, In: BMC Neuroscience. 19, Suppl 2, p. 68-69 1 p.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Fast gabaergic neurotransmission inhibits diversely AMPA and NMDA receptor mediated network dynamics in cortical cultures: A model-driven experimental study

  Teppola, H., Acimovic, J. & Linne, M-L., 29 Oct 2018, In: BMC Neuroscience. 19, Suppl 2, p. 69 1 p.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access

  • AMPA Receptors 100%
  • GABA-A Receptors 90%
  • N-Methyl-D-Aspartate Receptors 84%
  • Synaptic Transmission 79%
  • Theoretical Models 68%

• Improvement of computational efficiency of a biochemical plasticity model

  Lehtimäki, M., Paunonen, L. & Linne, M-L., 29 Sept 2018, In: BMC Neuroscience. 19, Suppl 2, p. 66-66 P130.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access

  • Theoretical Models 100%
  • Neurosciences 78%
  • Nonlinear Dynamics 64%
  • Neuronal Plasticity 46%
  • Brain 36%

• Voltage-gated sodium channels in retinal pigment epithelium – a real deal or an artifact?

  Johansson, J., Ihalainen, T., Skottman, H. & Nymark, S., Jul 2018, In: Investigative Ophthalmology and Visual Science. 59, 1189

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review
• 2017

  Astrocyte-modulated synaptic plasticity in sensory cortex: A computational study

  Saudargienė, A., Manninen, T., Havela, R. & Linne, M-L., 2017, In: BMC Neuroscience. 18, Suppl 1, P152.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Computational modeling of glial-neuronal interactions

  Linne, M-L., Havela, R. & Manninen, T., 2017, In: Glia. 65, S1

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access

• Connexin 43 translocation in retinal pigment epithelium during phagocytosis of photoreceptor outer segments

  Johansson, J., Ihalainen, T., Skottman, H. & Nymark, S., 2017, In: Investigative Ophthalmology and Visual Science. 58

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• In Silico Modeling of Human iPS Cardiomyocytes: Effect of Drugs and Comparison to Human Adult Cardiomyocytes

  Paci, M., Passini, E., Severi, S., Hyttinen, J. & Rodriguez, B., 2017, In: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. 88, p. 240-241

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Novel roles for voltage sensitive ion channels in retinal pigment epithelium and phagocytosis

  Nymark, S., Johansson, J., Skottman, H. & Ihalainen, T., 7 Sept 2017, In: Acta Ophthalmologica.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access
• 2016

  hGPR17 signaling cascade effects mitochondrial function

  Kandhavelu, M., 2016, In: The FEBS Journal. 283, S1

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Investigating retinal therapies using ex vivo retinal explants

  Alarautalahti, V., Ragauskas, S., Holme, A., Uusitalo-Järvinen, H., Uusitalo, H., Hyttinen, J., Kalesnykas, G. & Nymark, S., 24 Jun 2016, In: Frontiers in Neuroscience.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access

• Snoring detection with emfit sleep mattress

  Perez-Macias, J. M., Himanen, S-L., Viik, J. & Tenhunen, M., 2016, In: Journal of Sleep Research. 25, Suppl. 1

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Voltage-gated conductances increase the sensitivity of mouse rod photoresponses following pigment bleaching

  Frederiksen, R., Pahlberg, J., Polloc, G., Miyagishima, K., Nymark, S., Sampath, A. P. & Cornwall, M. C., Sept 2016, In: Investigative Ophthalmology and Visual Science. 57, 12

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review
• 2015

  ACI with Recombinant Human Type II Collagen / Polylactide Scaffold Enhances Articular Cartilage Repair in a Porcine Model

  Muhonen, V., Salonius, E., Haaparanta, A-M., Järvinen, E., Paatela, T., Meller, A., Hannula, M., Björkman, M., Pyhältö, T., Tanska, P., Aula, A., Ellä, V., Vasara, A. I., Töyräs, J., Kellomäki, M. & Kiviranta, I., 2015, In: Cartilage.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Dynamics of Epithelial Tight Junction as Molecular and Electric Barrier - A Computational Approach

  Tervonen, A., Nymark, S., Leon, D. G., Onnela, N. M. & Hyttinen, J., 2015, In: Investigative Ophthalmology and Visual Science. 56, 7

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Extending computational models of astrocyte-neuron interactions with biochemical mechanisms on the postsynaptic terminal

  Saudargienė, A., Manninen, T., Havela, R. & Linne, M-L., 2015, In: BMC Neuroscience.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• INEX – A simple but effective computational model to simulate neuronal-astrocytic activity

  Räisänen, E., Lenk, K. & Hyttinen, J., 2015, In: Glia. 63, S1

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Investigating the Function of BEST1 in iPS-RPE Cells Derived from a Family with Autosomal Recessive Bestrophinopathy

  Nymark, S., Nommiste, B., Vainio, I., Juuti-Uusitalo, K., da Cruz, L., Webster, A., Moore, A. T., Strauss, O. & Carr, A-J., 2015, In: Investigative Ophthalmology and Visual Science. 56, 7

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Numerical characterization of noisy fluctuations in two different types of stochastic differential equation models of neural signaling

  Manninen, T., Intosalmi, J., Ruohonen, K. & Linne, M-L., 2015, In: BMC Neuroscience. 16, Suppl 1

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Regular and irregular stimuli result in changes in mice eye movement and cerebellar nuclei neuron model behavior

  Manninen, T., Nguyen-Vu, T. D. B. & Raymond, J. L., 2015, In: BMC Neuroscience. 16, Suppl 1

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Response patterns in finger and central body skin temperatures under mild whole body cooling in an elderly and in a young male - a pre-study

  Kuklane, K., Vanggaard, L., Smolander, J., Halder, A., Lundgren, K., Gao, C., Viik, J. & Alametsä, J., 14 Sept 2015, In: Extreme Physiology & Medicine. 4, Suppl 1, A32.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  Open Access

• Spontaneous and mechanically induced Ca2+ activity changes in hESC‐RPE cells during maturation

  Abu Khamidakh, A., Juuti-Uusitalo, K., Caetano dos Santos, F., Skottman, H. & Hyttinen, J., 1 Oct 2015, In: Acta Ophthalmologica. 93, S225

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  • Human Embryonic Stem Cells 100%
  • Retinal Pigment Epithelium 95%
  • Gap Junctions 63%
  • Fluo 4 42%
  • Glycyrrhetinic Acid 41%

• Ultrathin polyimide membrane as potential carrier for subretinal transplantation of human embryonic stem cell derived RPE

  Ilmarinen, T., Hiidenmaa, H., Kööbi, P., Nymark, S., Sorkio, A., Wang, J-H., Alajuuma, P. T., Oksala, O. E., Uusitalo, H. M. T. & Skottman, H., 2015, In: Investigative Ophthalmology and Visual Science. 56, 7

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review
• 2014

  Fall accidents and actigraphy in nursing home

  Merilahti, J., Viramo, P. & Korhonen, I., Sept 2014, In: Journal of Sleep Research. 23, p. 242-242 1 p.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

  146 Citations (Scopus)
• 2013

  Computational model of Ca2+ wave propagation in human retinal pigment epithelium

  Vainio, I., Abu Khamidakh, A., Paci, M., Skottman, H., Juuti-Uusitalo, K., Hyttinen, J. & Nymark, S., 2013, In: Acta Ophthalmologica. 91, s252

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review
• 2011

  Contribution Of SERCA And IP3 Sensitivity to Calcium Signaling in Astrocytes: A Computational Study

  Toivari, E., Hituri, K., Manninen, T., Jalonen, T. O. & Linne, M-L., 2011, In: BMC Neuroscience. 12, Suppl 1, p. 1-2 2 p., P201.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review
• 2010

  Calcium signaling in astrocytes: modeling Fura-2AM measurements

  Toivari, E., Manninen, T., Nahata, A. K., Jalonen, T. O. & Linne, M-L., 2010, In: Frontiers in Neuroscience. 1 p.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Modeling signal transduction in synaptic plasticity: comparison of models and methods

  Manninen, T., Hituri, K., Toivari, E. & Linne, M-L., 2010, In: BMC Neuroscience. 11, 1, 1 p., P190.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review
• 2008

  Computational model for astroglial cell function in Alzheimer's disease

  Mäkiraatikka, E., Manninen, T., Nahata, A. K., Jalonen, T. O. & Linne, M-L., 2008, In: Frontiers in Neuroinformatics. 1 p.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Evaluation of deterministic and stochastic simulation tools for cellular signaling

  Pettinen, A., Mäkiraatikka, E., Manninen, T., Smolander, O-P., Ylipää, A., Hituri, K. & Linne, M-L., 2008, In: Frontiers in Neuroinformatics. 1 p.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Modeling long-term potentiation: deterministic and stochastic approaches

  Manninen, T. H., Hituri, K. & Linne, M-L., 2008, In: Frontiers in Neuroinformatics. 1 p.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review

• Stochastic modeling of neuronal signaling

  Intosalmi, J., Manninen, T., Ruohonen, K. & Linne, M-L., 2008, In: Frontiers in Neuroinformatics. 1 p.

  Research output: Contribution to journal › Meeting Abstract › Scientific › peer-review