NASY, Obstetrics and gynaecology

2025

Broadening the Phenotype Spectrum of MECP2 Variants in Men

Lötjönen, J., Kurra, V., Laivuori, H. & Bjelogrlić, N., Feb 2025, In: Molecular Genetics and Genomic Medicine. 13, 2, 8 p., e70056.

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Determination of steroid reference intervals in a pregnancy population

Lahti-Pulkkinen, M., Räikkönen, K., Basiukajc, A., Lee, P., Denham, S. G., Simpson, J. P., Villa, P., Hämäläinen, E., Laivuori, H., Kajantie, E., Heinonen, K., Girchenko, P., Reynolds, R. M. & Homer, N. Z., Apr 2025, In: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 248, 16 p., 106691.

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Efficacy of subsequent therapies in patients with advanced ovarian cancer who relapse after first-line olaparib maintenance: results of the PAOLA-1/ENGOT-ov25 trial

PAOLA-1/ENGOT-ov25 investigators, Harter, P., Marth, C., Mouret-Reynier, M. A., Cropet, C., Lorusso, D., Guerra-Alía, E. M., Matsumoto, T., Vergote, I., Colombo, N., Mäenpää, J., Lebreton, C., de Gregorio, N., Mosconi, A. M., Rubio-Pérez, M. J., Bourgeois, H., Fasching, P. A., Cecere, S. C., Hardy-Bessard, A. C. & Denschlag, D. & 11 others, de Percin, S., Hanker, L., Favier, L., Bauerschlag, D., Desauw, C., Hillemanns, P., Largillier, R., Sehouli, J., Grenier, J., Pujade-Lauraine, E. & Ray-Coquard, I., 2025, In: ANNALS OF ONCOLOGY. 36, 2, p. 185-196 12 p.

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Gluten-free diet during pregnancy and pregnancy outcome: A retrospective cohort study

Reijonen, J. K., Tihtonen, K. M. H., Luukkaala, T. H. & Uotila, J. T., 2025, (E-pub ahead of print) In: INTERNATIONAL JOURNAL OF GYNECOLOGY AND OBSTETRICS. 7 p.

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Intracranial Arteriovenous Malformations During Pregnancy and Puerperium: A Retrospective Nationwide Population-Based Cohort Study

Pohjola, A., Vest, T., Verho, L., Aarnio, K., Rantanen, K., Laivuori, H., Gissler, M., Laakso, A., Niemelä, M. & Ijäs, P., 1 Feb 2025, In: Neurosurgery. 96, 2, p. 346-355 10 p.

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Intrauterine Contraction Monitoring in Chorioamnionitis: A Secondary, Blinded Analysis of a Randomised Controlled Trial Cohort

Juhantalo, M., Hautakangas, T., Palomäki, O. & Uotila, J., 2025, (E-pub ahead of print) In: BJOG: AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 10 p.

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Maternal Antenatal Depression Is Associated With Metabolic Alterations That Predict Birth Outcomes and Child Neurodevelopment and Mental Health

Girchenko, P., Lahti-Pulkkinen, M., Laivuori, H., Kajantie, E. & Räikkönen, K., Feb 2025, In: BIOLOGICAL PSYCHIATRY. 97, 3, p. 269-278

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Metabolic profiles of meconium in preeclamptic and normotensive pregnancies

Toivonen, E., Sikkinen, J., Salonen, A., Kärkkäinen, O., Koistinen, V., Klåvus, A., Meuronen, T., Heini, T., Maltseva, A., Niku, M., Jääskeläinen, T. & Laivuori, H., 25 Jan 2025, In: Metabolomics. 21, 1, p. 21 1 p.

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Palbociclib plus letrozole in estrogen receptor-positive advanced/recurrent endometrial cancer: Double-blind placebo-controlled randomized phase II ENGOT-EN3/PALEO trial

Mirza, M. R., Bjørge, L., Marmé, F., Christensen, R. D. P., Gil-Martin, M., Auranen, A., Ataseven, B., Rubio, M. J., Salutari, V., Luczak, A. A., Runnebaum, I. B., Redondo, A., Lindemann, K., Trillsch, F., Ginesta, M. P. B., Roed, H., Kurtz, J. E., Petersson, K. S., Nyvang, G. B. & Sehouli, J., Jan 2025, In: Gynecologic Oncology. 192, p. 128-136 9 p.

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2024

Acute recanalization therapy for ischemic stroke during pregnancy and puerperium

Richardt, A., Aarnio, K., Korhonen, A., Rantanen, K., Verho, L., Curtze, S., Laivuori, H., Gissler, M., Tikkanen, M. & Ijäs, P., 2024, In: JOURNAL OF NEUROLOGY. 271, 7, p. 4046-4056 11 p.

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Ascorbic Acid 2-Phosphate Releasing Supercritically Foamed Porous Poly-L-Lactide-Co-ε-Caprolactone Scaffold Enhances the Collagen Production of Human Vaginal Stromal Cells: A New Approach for Vaginal Tissue Engineering

Sartoneva, R., Paakinaho, K., Hannula, M., Kuismanen, K., Huhtala, H., Hyttinen, J. & Miettinen, S., Jan 2024, In: TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 21, 1, p. 81-96 16 p.

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Associations of polymetabolic risk of high maternal pre-pregnancy body mass index with pregnancy complications, birth outcomes, and early childhood neurodevelopment: findings from two pregnancy cohorts

Girchenko, P., Lahti-Pulkkinen, M., Hämäläinen, E., Laivuori, H., Villa, P. M., Kajantie, E. & Räikkönen, K., Jan 2024, In: Bmc Pregnancy And Childbirth. 24, 16 p., 78.

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Beyond HRD Status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer

Kjeldsen, M. K., Jørgensen, M., Grønseth, D. S. B., Schønemann-Lund, M., Nyvang, G. B., Haslund, C. A., Knudsen, A. O., Motavaf, A. K., Malander, S., Anttila, M., Lindahl, G., Mäenpää, J., Dimoula, M., Werner, T. L., Iversen, T. Z., Hietanen, S., Fokdal, L., Dahlstrand, H., Bjørge, L. & Birrer, M. J. & 2 others, Mirza, M. R. & Rossing, M., Dec 2024, In: Cancer research communications. 4, 12, p. 3190-3200 11 p.

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Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry

Burns, K., Mullin, B. H., Moolhuijsen, L. M. E., Laisk, T., Tyrmi, J. S., Cui, J., Actkins, K. V., Louwers, Y. V., Davis, L. K., Dudbridge, F., Azziz, R., Goodarzi, M. O., Laivuori, H., Mägi, R., Visser, J. A., Laven, J. S. E., Wilson, S. G., FinnGen, International PCOS Consortium & Day, F. R. & 1 others, Stuckey, B. G. A., 2024, In: BMC Genomics. 25, 1, 15 p., 208.

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Cardiac Structure and Function in 8- to 12-Year-Old Children Following In-Utero Exposure to Preeclampsia (FINNCARE Study)

Renlund-Vikström, M., Jääskeläinen, T. J., Kivelä, A., Heinonen, S., Laivuori, H. & Sarkola, T., 6 Aug 2024, In: Journal of the American Heart Association. 13, 15, 14 p., e034494.

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Changes in Stress Urinary Incontinence Symptoms after Pelvic Organ Prolapse Surgery: a Nationwide Cohort Study (FINPOP)

Karjalainen, P. K., Tolppanen, A. M., Wihersaari, O., Nieminen, K., Mattsson, N. K. & Jalkanen, J. T., 2024, In: INTERNATIONAL UROGYNECOLOGY JOURNAL. 35, p. 909–919 11 p.

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Clinical evaluation of a low-coverage whole-genome test for detecting homologous recombination deficiency in ovarian cancer

Boidot, R., Blum, M. G. B., Wissler, M. P., Gottin, C., Ruzicka, J., Chevrier, S., Delhomme, T. M., Audoux, J., Jeanniard, A., Just, P. A., Harter, P., Pignata, S., González-Martin, A., Marth, C., Mäenpää, J., Colombo, N., Vergote, I., Fujiwara, K., Duforet-Frebourg, N. & Bertrand, D. & 3 others, Philippe, N., Ray-Coquard, I. & Pujade-Lauraine, E., May 2024, In: EUROPEAN JOURNAL OF CANCER. 202, 8 p., 113978.

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Clinical features of preeclampsia and hypertensive disorders in pregnancies after different frozen embryo transfer regimens

Pohjonen, E. M., Ahinko, K., Huhtala, H., Erkinaro, T., Lehto, J., Pellas, E., Vilmi-Kerälä, T. & Laivuori, H., Jun 2024, In: PREGNANCY HYPERTENSION. 36, 6 p., 101123.

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Comparison of balloon catheter, oral misoprostol, or combination of both for cervical ripening in late-term and post-term nulliparous women: A Finnish randomized controlled multicenter pilot trial

Kruit, H., Place, K., Väyrynen, K., Orden, M. R., Tekay, A., Vääräsmäki, M., Uotila, J., Tihtonen, K., Rinne, K., Mäkikallio, K., Heinonen, S. & Rahkonen, L., 13 Dec 2024, (E-pub ahead of print) In: Acta Obstetricia et Gynecologica Scandinavica. 11 p.

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COVID-19 pandemic impact on gynecologic cancer treatment pathways in a Finnish tertiary center

Pikkujämsä, H., Luukkaala, T., Nyberg, R. H. & Louvanto, K., 2024, (E-pub ahead of print) In: Acta Obstetricia et Gynecologica Scandinavica. 10 p.

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Delayed versus early delivery leads to similar outcome in selected cases of preeclampsia in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort

Kivisilta, K., Toivonen, E., Kiverä, A., Kortelainen, E., FINNPEC Core Investigator Group, Uotila, J. & Laivuori, H., Jun 2024, In: PREGNANCY HYPERTENSION. 36, 5 p., 101129.

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Delivery mode and subsequent birth rate: A nationwide register-based analysis in Finland

Vaajala, M., Liukkonen, R., Mattila, V. M., Kekki, M. & Kuitunen, I., 2024, (E-pub ahead of print) In: INTERNATIONAL JOURNAL OF GYNECOLOGY AND OBSTETRICS.

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Etiology of intracerebral hemorrhage during pregnancy or puerperium: A nationwide study

Vest, T., Rantanen, K., Verho, L., Aarnio, K., Korhonen, A., Richardt, A., Strbian, D., Gissler, M., Laivuori, H., Tikkanen, M. & Ijäs, P., 2024, In: European Journal of Neurology. 31, 3, 11 p., e16012.

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Fear of Childbirth After Major Orthopedic Traumas: A Nationwide Multi-Register Analysis

Vaajala, M., Liukkonen, R., Kuitunen, I., Ponkilainen, V., Mattila, V. & Kekki, M., 2024, (E-pub ahead of print) In: Birth. 6 p.

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Fetal cord plasma herpesviruses and preeclampsia: an observational cohort study

Häkkinen, I., Yazgeldi Gunaydin, G., Pyöriä, L., Kojima, S., Parrish, N., Perdomo, M. F., Wedenoja, J., Hedman, K., Heinonen, S., Kajantie, E., Laivuori, H., Kere, J., Katayama, S. & Wedenoja, S., 2024, In: Scientific Reports. 14, 7 p., 14605.

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Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage

FinnGen, Danish Blood Donor Study Genomic Consortium, Estonian Biobank Research Team, Nordic Collaboration for Womens and Reproductive Health, Westergaard, D., Steinthorsdottir, V., Stefansdottir, L., Rohde, P. D., Wu, X., Geller, F., Tyrmi, J., Havulinna, A. S., Solé-Navais, P., Flatley, C., Ostrowski, S. R., Pedersen, O. B., Erikstrup, C., Sørensen, E., Mikkelsen, C. & Bruun, M. T. & 25 others, Aagaard Jensen, B., Brodersen, T., Ullum, H., Magnus, P., Andreassen, O. A., Njolstad, P. R., Kolte, A. M., Krebs, L., Nyegaard, M., Hansen, T. F., Feenstra, B., Daly, M., Lindgren, C. M., Thorleifsson, G., Stefansson, O. A., Sveinbjornsson, G., Gudbjartsson, D. F., Thorsteinsdottir, U., Banasik, K., Jacobsson, B., Laisk, T., Laivuori, H., Stefansson, K., Brunak, S. & Nielsen, H. S., 2024, In: Nature Genetics. 56, 8, p. 1597-1603 7 p.

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Human papillomavirus concordance between parents and their newborn offspring: Results from the Finnish Family HPV study

Suominen, N. T., Luukkaala, T. H., Laprise, C., Haataja, M. A., Grénman, S. E., Syrjänen, S. M. & Louvanto, K., 2024, In: Journal of Infectious Diseases. 229, 2, 9 p., jiad330.

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Impact of Different Cofactors on Naturally Acquired Human Papillomavirus Antibody Levels Among Unvaccinated Pregnant Women

Kirjavainen, L., Suominen, H., Syrjänen, K., Waterboer, T., Grenman, S., Syrjänen, S. & Louvanto, K., 13 Feb 2024, In: VIRAL IMMUNOLOGY. 37, 1, p. 36-43 8 p.

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Impact of physical activity on preeclampsia and angiogenic markers in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort

Jaatinen, N., Ekholm, E., Laivuori, H., Jääskeläinen, T. & FINNPEC, 2024, In: Annals of Medicine. 56, 1, 9 p., 2325480.

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Inherited infertility: Mapping loci associated with impaired female reproduction

FinnGen, Ruotsalainen, S., Karjalainen, J., Kurki, M., Lahtela, E., Pirinen, M., Riikonen, J., Ritari, J., Tammi, S., Partanen, J., Laivuori, H., Palotie, A., Heyne, H., Daly, M. & Widen, E., 5 Dec 2024, In: AMERICAN JOURNAL OF HUMAN GENETICS. 111, 12, p. 2789-2798 10 p.

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Kohdunsisäisiä ongelmia voi hoitaa tähystyksessä

Juhantalo, M. & Vehkaoja, L., 2024, In: Suomen Lääkärilehti. 79, 49-50, p. 2001-2004 4 p.

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Labor induction at 41+0 gestational weeks or expectant management for the nulliparous woman: The Finnish randomized controlled multicenter trial

Place, K., Rahkonen, L., Tekay, A., Väyrynen, K., Orden, M.-R., Vääräsmäki, M., Uotila, J., Tihtonen, K., Rinne, K., Mäkikallio, K., Heinonen, S. & Kruit, H., Mar 2024, In: Acta Obstetricia et Gynecologica Scandinavica. 103, 3, p. 505-511

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Long-Term Mortality, Recovery, and Vocational Status After a Maternal Stroke: Register-Based Observational Case-Control Study

Verho, L., Aarnio, K., Tikkanen, M., Äyräs, O., Rantanen, K., Korhonen, A., Richardt, A., Laivuori, H., Gissler, M. & Ijäs, P., 2024, In: Neurology. 103, 2, e209532.

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Low methylation marker levels among human papillomavirus-vaccinated women with cervical high-grade squamous intraepithelial lesions

Louvanto, K., Verhoef, L., Pimenoff, V., Eriksson, T., Leppälä, S., Lagheden, C., Gray, P., Scibior-Bentkowska, D., Sumiec, E., Nieminen, P., Dillner, J., Berkhof, J., Meijer, C. J. L. M., Lehtinen, M., Nedjai, B. & Heideman, D. A. M., Sept 2024, In: International Journal of Cancer. 155, 9, p. 1549-1557

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Maternal gestational hypertension, smoking and pre-eclampsia are associated with metabolic dysfunction-associated fatty liver disease in overweight offspring

de Ruyter, H., Aitokari, L., Lahti, S., Riekki, H., Huhtala, H., Lakka, T., Laivuori, H. & Kurppa, K., May 2024, In: Acta Obstetricia et Gynecologica Scandinavica. 103, 6, p. 1183-1191

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Maternal psychological distress and temperament traits in children from infancy to late childhood

Lahti-Pulkkinen, M., Lähdepuro, A., Lahti, J., Girchenko, P., Pyhälä, R., Reynolds, R. M., Villa, P. M., Laivuori, H., Kajantie, E., Heinonen, K. & Räikkönen, K., Sept 2024, In: JCPP Advances. 4, 3, 15 p., e12242.

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Novel Biomarkers: Soluble Urokinase-Type Plasminogen Activator Receptor and Procalcitonin- and Histological Chorioamnionitis after Preterm Premature Rupture of Membranes

Jalkanen, K., Virtanen, A., Aittoniemi, J., Flinck, H., Ampuja, S., Huhtala, H. & Tihtonen, K., Oct 2024, In: REPRODUCTIVE SCIENCES. 31, p. 3175–3182

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NSGO-OV-UMB1/ENGOT-OV30: A phase II study of durvalumab in combination with the anti-CD73 monoclonal antibody Oleclumab in patients with relapsed ovarian cancer

Mirza, M. R., Tandaric, L., Henriksen, J. R., Mäenpää, J., Christensen, R. D., Waldstrøm, M., Lindemann, K., Roed, H., Auranen, A., Akslen, L. A., Thomsen, L. C. V., Lindberg, S. N., Madsen, K. & Bjørge, L., Sept 2024, In: Gynecologic Oncology. 188, p. 103-110 8 p.

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Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study

Kerola, A. M., Palomäki, A., Laivuori, H., Laitinen, T., Färkkilä, M., Eklund, K. K., Ripatti, S., Perola, M., Ganna, A., Lindbohm, J. V. & Mars, N., Oct 2024, In: Rheumatology. 63, 10, p. 2701-2710 10 p.

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Perinatal and neonatal outcomes in gestational diabetes: The importance of the number of abnormal values in an oral glucose tolerance test

Eteläinen, S., Keikkala, E., Lingaiah, S., Viljakainen, M., Männistö, T., Pouta, A., Kaaja, R., Eriksson, J. G., Laivuori, H., Gissler, M., Kajantie, E. & Vääräsmäki, M., 2024, (E-pub ahead of print) In: Acta Obstetricia et Gynecologica Scandinavica. 9 p.

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Predictors of long-term progression-free survival in patients with ovarian cancer treated with niraparib in the PRIMA/ENGOT-OV26/GOG-3012 study

Graybill, W. S., Pardo Búrdalo, B., O'Malley, D. M., Vergote, I., Monk, B. J., Auranen, A., Copeland, L. J., Sabbatini, R., Herzog, T. J., Follana, P., Pothuri, B., Braicu, E. I., McCormick, C., Yubero, A., Moore, R. G., Vuylsteke, P., Raaschou-Jensen, N., York, W., Hartman, J. & González-Martín, A., 1 Jul 2024, (E-pub ahead of print) In: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 34, 7, p. 1041-1050 10 p.

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Preeclampsia-exposed children's heart rate variability 8-12 yr after index pregnancy: FINNCARE study

Renlund, M., Tulppo, M. P., Kivelä, A., Laivuori, H., Heinonen, S., Jääskeläinen, T. & Sarkola, T., Jan 2024, In: Am J Physiol Heart Circ Physiol. 326, 1, p. H74-H81

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Prognostic factors and overall survival among patients with ovarian cancer in the pre-PARP inhibitor era: the OCRWE-Finland study

Lahelma, M., Rauhamaa, H., Leskelä, R.-L., Isomeri, O., Idänpään-Heikkilä, J., Käkelä, S., Roebuck, N., Mascialino, B., Hietanen, S., Loukovaara, M. & Auranen, A., 16 Oct 2024, In: Acta Oncologica. 63, p. 763-771 9 p.

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Promoting cell proliferation and collagen production with ascorbic acid 2-phosphate-releasing poly(l-lactide-co- ϵ-caprolactone) membranes for treating pelvic organ prolapsed

Kurki, A., Paakinaho, K., Hannula, M., Karjalainen, S., Kuismanen, K., Hyttinen, J., Miettinen, S. & Sartoneva, R., 2024, In: Regenerative Biomaterials. 11, rbae060.

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Quality of Sexual Life Before and After Pelvic Organ Prolapse Surgery

Wihersaari, O. A. E., Karjalainen, P., Tolppanen, A.-M., Mattsson, N., Nieminen, K. & Jalkanen, J., Oct 2024, In: Urogynecology. 30, 10, p. 838-846 9 p.

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Raskaana olevan syöpä - milloin epäilen ja miten tutkin?

Kyllönen, S., Tiainen, L., Pollari, M. & Staff, S., 2024, In: Duodecim. 140, 22, p. 1900-1906 7 p.

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Real-life treatment patterns and time to next treatment among patients with ovarian cancer in the pre-PARP inhibitor era: the OCRWE-Finland Study

Lahelma, M., Rauhamaa, H., Isomeri, O., Idänpään-Heikkilä, J., Käkelä, S., Roebuck, N., Mascialino, B., Hietanen, S., Loukovaara, M. & Auranen, A., 16 Oct 2024, In: Acta Oncologica. 63, p. 772-782 11 p.

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Reproducibility of colposcopy quality indicators—A survey among members of the European Federation for Colposcopy

Randrup, T. H., Leeson, S., Ciavattini, A., Eldib, A., Grigore, M., van Haaften-de Jong, A. M., Jariene, K., Kesic, V., Koiss, R., Kotaniemi-Talonen, L., Quaas, J., Raud, T., Zodzika, J. & Hammer, A., Aug 2024, In: Acta Obstetricia et Gynecologica Scandinavica. 103, 9, p. 1745-1752

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Risk assessment of hypertensive disorders of pregnancy and other adverse pregnancy outcomes after frozen embryo transfers following an artificial cycle: A retrospective cohort study

Pohjonen, E. M., Huhtala, H., Erkinaro, T., Lehto, J., Pellas, E., Vilmi-Kerälä, T., Laivuori, H. & Ahinko, K., 2024, (E-pub ahead of print) In: INTERNATIONAL JOURNAL OF GYNECOLOGY AND OBSTETRICS. 8 p.

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Robotic-assisted versus conventional laparoscopic surgery for endometrial cancer: long-term results of a randomized controlled trial

Kivekäs, E., Staff, S., Huhtala, H. S. A., Mäenpää, J. U., Nieminen, K., Tomás, E. I. & Mäenpää, M. M., 2024, (E-pub ahead of print) In: American Journal of Obstetrics and Gynecology.

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NASY, Obstetrics and gynaecology

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