Hannele Uusitalo-Järvinen

Research output

Research output per year 2013 2017 2018 2019 2020 2022 2023 2023

• 26 Article
• 2 Review Article
• 1 Comment/debate

Research output per year

Research output per year

Search results

• 2023

  Glaucoma progression in patients receiving intravitreal anti-VEGF treatment for neovascular age-related macular degeneration

  Pirinen, I., Leinonen, S., Helminen, M., Hujanen, P., Vaajanen, A., Tuulonen, A. & Uusitalo-Järvinen, H., 2023, In: Acta Ophthalmologica. 101, 3, p. 261-265 5 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Macular Degeneration 100%
  • Glaucoma 90%
  • Vascular Endothelial Growth Factor A 82%
  • Neovascular Glaucoma 68%
  • Eye 51%

• Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy

  Vähätupa, M., Nättinen, J., Aapola, U., Uusitalo-Järvinen, H., Uusitalo, H. & Järvinen, T. A. H., Apr 2023, In: International Journal of Molecular Sciences. 24, 9, 13 p., 7914.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Proteomics 100%
  • Retinal 86%
  • retina 68%
  • angiogenesis 67%
  • Mass Spectrum 64%
  7 Downloads (Pure)

• Ten-year real-world outcomes of antivascular endothelial growth factor therapy in neovascular age-related macular degeneration using pro re nata regimen

  Hujanen, P., Ruha, H., Lehtonen, E., Pirinen, I., Huhtala, H., Vaajanen, A., Syvänen, U., Tuulonen, A. & Uusitalo-Järvinen, H., 2023, In: BMJ Open Ophthalmology. 8, 1, e001328.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Endothelial Growth Factors 100%
  • Macular Degeneration 71%
  • Visual Acuity 42%
  • Eye 24%
  • Intravitreal Injections 23%
• 2022

  A comprehensive model for measuring real-life cost-effectiveness in eyecare: automation in care and evaluation of system (aces-rwm™)

  Tuulonen, A., Kataja, M., Aaltonen, V., Kinnunen, K., Moilanen, J., Saarela, V., Linna, M., Malmivaara, A. & Uusitalo-Jarvinen, H., 2022, In: Acta Ophthalmologica. 100, 3, p. e833-e840

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Automation 100%
  • Ophthalmology 84%
  • Cost-Benefit Analysis 70%
  • Ecosystem 44%
  • Benchmarking 43%
  23 Downloads (Pure)

• Arkivaikuttavuuden arviointi yhdellä mittarilla

  Pakarinen, S., Tuulonen, A., Uusitalo-Järvinen, H., Kankaanpää, M. & Sintonen, H., 2022, In: Suomen Lääkärilehti. 77, 33-34, p. 1354-1355 2 p.

  Research output: Contribution to journal › Article › Professional

  Open Access

  File

• Immediate sequential bilateral cataract surgery: A 13-year real-life report of 56 700 cataract operations

  Hujanen, P., Vaajanen, A., Felin, T., Lehtonen, E., Syvänen, U., Huhtala, H., Helminen, M., Sintonen, H., Tuulonen, A. & Uusitalo-Järvinen, H., Oct 2022, (E-pub ahead of print) In: BRITISH JOURNAL OF OPHTHALMOLOGY. 5 p., A85.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Cataract 100%
  • Endophthalmitis 59%
  • Finland 10%
  • University Hospitals 7%
  • Eye 6%
• 2021

  Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization

  De Rossi, G., Vähätupa, M., Cristante, E., Arokiasamy, S., Liyanage, S. E., May, U., Pellinen, L., Uusitalo-Järvinen, H., Bainbridge, J. W., Järvinen, T. A. H. & Whiteford, J. R., 2021, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 41, 4, p. 1374-1389 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Syndecan-4 100%
  • Pathologic Neovascularization 87%
  • cadherin 5 84%
  • Vascular Endothelial Growth Factor A 53%
  • Heparan Sulfate Proteoglycans 22%
  2 Citations (Scopus)

  4 Downloads (Pure)

• Selective targeting and tissue penetration to the retina by a systemically administered vascular homing peptide in oxygen induced retinopathy (OIR)

  Vähätupa, M., Salonen, N., Uusitalo-Järvinen, H. & Järvinen, T. A. H., 2021, In: Pharmaceutics. 13, 11, 1932.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Retina 100%
  • Oxygen 82%
  • Retinal 79%
  • Peptides 73%
  • Hyperoxia 71%
  8 Downloads (Pure)
• 2020

  An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease

  Ruotsalainen, S. E., Partanen, J. J., Cichonska, A., Lin, J., Benner, C., Surakka, I., FinnGen, Palotie, A., Daly, M., Jacob, H., Matakidou, A., Runz, H., John, S., Plenge, R., McCarthy, M., Hunkapiller, J., Ehm, M., Waterworth, D., Fox, C., Malarstig, A., & 27 othersPartanen, J., Savinainen, K., Kosma, V. M., Schleutker, J., Laaksonen, R., Mannermaa, A., Peltola, J., Rinne, J., Jussila, A., Isomäki, P., Laitinen, T., Kankaanranta, H., Kähönen, M., Auranen, A., Uusitalo, H., Uusitalo-Järvinen, H., Salmi, T., Harju, J., Wahlfors, T., Mannermaa, A., Kononen, J., Shcherban, A., Laivuori, H., Siirtola, H., Gracia Tabuenca, J., Partanen, J. & Pirinen, M., 27 Oct 2020, In: EUROPEAN JOURNAL OF HUMAN GENETICS. 29, 2, p. 309-324 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  • Genome-Wide Association Study 100%
  • Multivariate Analysis 67%
  • Biomarkers 62%
  • Workflow 52%
  • Phenotype 43%

• Exploration of Oxygen-Induced Retinopathy Model to Discover New Therapeutic Drug Targets in Retinopathies

  Vähätupa, M., Järvinen, T. A. H. & Uusitalo-Järvinen, H., 2020, In: FRONTIERS IN PHARMACOLOGY. 11, p. 873 873.

  Research output: Contribution to journal › Review Article › peer-review
  3 Citations (Scopus)

• Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

  FinnGen, 23andMe Research Team, Bao, E. L., Nandakumar, S. K., Liao, X., Bick, A. G., Karjalainen, J., Tabaka, M., Gan, O. I., Havulinna, A. S., Kiiskinen, T. T. J., Lareau, C. A., de Lapuente Portilla, A. L., Li, B., Emdin, C., Codd, V., Nelson, C. P., Walker, C. J., Churchhouse, C., de la Chapelle, A., & 26 othersKlein, D. E., Nilsson, B., Wilson, P. W. F., Cho, K., Partanen, J., Savinainen, K., Kosma, V. M., Schleutker, J., Laaksonen, R., Peltola, J., Jussila, A., Isomäki, P., Laitinen, T., Kankaanranta, H., Kähönen, M., Auranen, A., Uusitalo, H., Uusitalo-Järvinen, H., Salmi, T., Wahlfors, T., Mannermaa, A., Kononen, J., Laivuori, H., Shcherban, A., Siirtola, H. & Tabuenca, J. G., Oct 2020, In: Nature. 586, 7831, p. 769-775 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • Hematopoietic Stem Cells 100%
  • Neoplasms 32%
  • Chromosome Mapping 11%
  • Genetic Loci 11%
  • Telomere 10%
  8 Citations (Scopus)

• Oxygen-induced retinopathy model for ischemic retinal diseases in rodents

  Vähätupa, M., Jääskeläinen, N., Cerrada-Gimenez, M., Thapa, R., Järvinen, T., Kalesnykas, G. & Uusitalo-Järvinen, H., 2020, In: Journal of Visualized Experiments. 2020, 163, 19 p., e61482.

  Research output: Contribution to journal › Article › Scientific › peer-review

  • Retinal Diseases 100%
  • Rodentia 67%
  • Oxygen 57%
  • Hyperoxia 50%
  • Retinal Neovascularization 28%
  2 Citations (Scopus)

• The role of polygenic risk and susceptibility genes in breast cancer over the course of life

  Mars, N., Widén, E., Kerminen, S., Meretoja, T., Pirinen, M., della Briotta Parolo, P., Palta, P., Palotie, A., Kaprio, J., Joensuu, H., Daly, M. J., Ripatti, S., FinnGen, Mäkelä, J., Auranen, A., Jussila, A., Uusitalo-Järvinen, H., Kankaanranta, H., Uusitalo, H., Peltola, J., & 6 othersKähönen, M., Laitinen, T., Salmi, T., Laivuori, H., Shcherban, A. & Siirtola, H., 2020, In: Nature Communications. 11, 1, 6383.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Risk Assessment 100%
  • genes 96%
  • breast 87%
  • cancer 77%
  • magnetic permeability 60%
  4 Citations (Scopus)

  3 Downloads (Pure)
• 2019

  Expression of VEGFA-regulating miRNAs and mortality in wet AMD

  Blasiak, J., Watala, C., Tuuminen, R., Kivinen, N., Koskela, A., Uusitalo-Jarvinen, H., Tuulonen, A., Winiarczyk, M., Mackiewicz, J., Zmorzynski, S., Filip, A. & Kaarniranta, K., 2019, In: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 23, 12, p. 8464-8471

  Research output: Contribution to journal › Article › Scientific › peer-review
  9 Citations (Scopus)

• Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium

  Korkka, I., Viheriälä, T., Juuti-Uusitalo, K., Uusitalo-Järvinen, H., Skottman, H., Hyttinen, J. & Nymark, S., 2019, In: Stem Cells Translational Medicine. 8, 2, p. 179-193

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Human Embryonic Stem Cells 100%
  • Retinal Pigment Epithelium 95%
  • Calcium Channels 89%
  • pericentrin 18%
  • Transplantation 15%
  10 Citations (Scopus)

  44 Downloads (Pure)

• Genetic architecture of human plasma lipidome and its link to cardiovascular disease

  Tabassum, R., Rämö, J. T., Ripatti, P., Koskela, J. T., Kurki, M., Uusitalo-Järvinen, H., Karjalainen, J., Kankaanranta, H., Palta, P., Hassan, S., Peltola, J., Nunez-Fontarnau, J., Kähönen, M., Kiiskinen, T. T. J., Isomäki, P., Söderlund, S., Salmi, T., Matikainen, N., Auranen, A., Gerl, M. J., & 22 othersLaitinen, T., Surma, M. A., Savinainen, K., Klose, C., Laaksonen, R., Stitziel, N. O., Laivuori, H., Havulinna, A. S., Service, S. K., Salomaa, V., Pirinen, M., Jauhiainen, M., Daly, M. J., Freimer, N. B., Palotie, A., Taskinen, M-R., Simons, K., Ripatti, S., FinnGen, P., Gracia Tabuenca, J., Siirtola, H. & Uusitalo, H., 2019, In: Nature Communications. 10, 1, p. 4329 4329.

  Research output: Contribution to journal › Article › Scientific › peer-review
  23 Citations (Scopus)

• Real-world efficacy and safety of dividing aflibercept into three syringes in the treatment of wet age-related macular degeneration

  Hujanen, P., Tuulonen, A. & Uusitalo-Järvinen, H., 2019, In: Acta ophthalmologica. 97, 5, p. e812-e813

  Research output: Contribution to journal › Comment/debate › Scientific

• R-Ras regulates vascular permeability, but not overall healing in skin wounds

  Ketomäki, T., Vähätupa, M., May, U., Pemmari, T., Ruikka, E., Hietamo, J., Kaipiainen, P., Barker, H., Parkkila, S., Uusitalo-Järvinen, H. & Järvinen, T. A. H., 2019, In: Experimental Dermatology. 28, 2, p. 202-206

  Research output: Contribution to journal › Article › Scientific › peer-review
  5 Citations (Scopus)

• Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology

  Alarautalahti, V., Ragauskas, S., Hakkarainen, J. J., Uusitalo-Järvinen, H., Uusitalo, H., Hyttinen, J., Kalesnykas, G. & Nymark, S., 2019, In: Investigative ophthalmology & visual science. 60, 6, p. 1914-1927 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • In Vitro Techniques 100%
  • Retinal Ganglion Cells 98%
  • Retina 49%
  • Tissue Preservation 40%
  • Eye 35%
  9 Citations (Scopus)

  24 Downloads (Pure)
• 2018

  Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy

  Vähätupa, M., Martinez Cordova, Z., Cordova, ZM., Barker, H., Aittomäki, S., Uusitalo, H., Järvinen, T., Pesu, M. & Uusitalo-Järvinen, H., 2018, In: Experimental Eye Research. 166, p. 160-167

  Research output: Contribution to journal › Article › Scientific › peer-review
  7 Citations (Scopus)

• Outcome of anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration in real-life setting

  Kataja, M., Hujanen, P., Huhtala, H., Kaarniranta, K., Tuulonen, A. & Uusitalo-Järvinen, H., 2018, In: BRITISH JOURNAL OF OPHTHALMOLOGY. 102, 7, p. 959-965

  Research output: Contribution to journal › Article › Scientific › peer-review
  16 Citations (Scopus)

• SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets

  Vähätupa, M., Nättinen, J., Jylhä, A., Aapola, U., Kataja, M., Kööbi, P., Järvinen, T., Uusitalo, H. & Uusitalo-Järvinen, H., 2018, In: Investigative ophthalmology & visual science. 59, 8, p. 3294-3306

  Research output: Contribution to journal › Article › Scientific › peer-review
  11 Citations (Scopus)
• 2017

  Role of carbonic anhydrases in skin wound healing

  Barker, H., Aaltonen, M., Pan, P., Vähätupa, M., Kaipiainen, P., May, U., Prince, S., Uusitalo-Järvinen, H., Waheed, A., Pastorekova, S., Sly, W. S., Parkkila, S. & Järvinen, T. A. H., 2017, In: EXPERIMENTAL AND MOLECULAR MEDICINE. 49, 5, p. e334 e334.

  Research output: Contribution to journal › Article › Scientific › peer-review
  24 Citations (Scopus)

• R-Ras deficiency does not affect papain-induced IgE production in mice

  Kummola, L., Ortutay, Z., Vähätupa, M., Prince, S., Uusitalo-Järvinen, H., Järvinen, T. AH. & Junttila, I., 2017, In: Immunity, Inflammation And Disease. 5, 3, p. 280-288

  Research output: Contribution to journal › Article › Scientific › peer-review
  1 Citation (Scopus)

• The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age related macular degeneration

  Tuuminen, R., Uusitalo-Järvinen, H., Aaltonen, V., Hautala, N., Kaipiainen, S., Laitamäki, N., Ollila, M., Rantanen, J., Välimaki, S., Sipilä, R., Laukkala, T., Komulainen, J., Tommila, P., Immonen, I., Tuulonen, A. & Kaarniranta, K., 2017, In: Acta ophthalmologica. 95, A105, p. 1-9

  Research output: Contribution to journal › Review Article › peer-review
  16 Citations (Scopus)
• 2016

  Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy

  Vähätupa, M., Prince, S., Vataja, S., Mertimo, T., Kataja, M., Kinnunen, K., Varpu, M., Marjomäki, V., Uusitalo, H., Komatsu, M., Järvinen, T. A. H. & Uusitalo-Järvinen, H., 2016, In: Investigative Ophthalmology and Visual Science. 57, 11, p. 4898-4909

  Research output: Contribution to journal › Article › Scientific › peer-review
  18 Citations (Scopus)

• T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development

  Vähätupa, M., Aittomäki, S., Martinez Cordova, Z., Cordova, Z., May, U., Prince, S., Uusitalo-Järvinen, H., Järvinen, T. A. & Pesu, M., 2016, In: OncoImmunology. 5, 12, p. e1245266 e1245266.

  Research output: Contribution to journal › Article › Scientific › peer-review
  7 Citations (Scopus)
• 2015

  Resistance of R-Ras knockout mice to skin tumour induction

  May, U., Prince, S., Vähätupa, M., Laitinen, A. M., Nieminen, K., Uusitalo-Järvinen, H. & Järvinen, T. A., 2015, In: Scientific Reports. 5, p. 11663 11663.

  Research output: Contribution to journal › Article › Scientific › peer-review
  14 Citations (Scopus)
• 2013

  LDLR–/–ApoB100/100 mice with insulin-like growth factor II overexpression reveal a novel form of retinopathy with photoreceptor atrophy and altered morphology of the retina

  Kinnunen, K., Heinonen, S. E., Kalesnykas, G., Laidinen, S., Uusitalo-Järvinen, H., Uusitalo, H. & Ylä-Herttuala, S., 2013, In: Molecular Vision. 19, p. 1723-1733

  Research output: Contribution to journal › Article › Scientific › peer-review

  3 Citations (Scopus)