Joonas Haapasalo

2025

Unsupervised clustering reveals noncanonical myeloid cell subsets in the brain tumor microenvironment

Hermelo, I., Virtanen, T., Salonen, I., Nätkin, R., Keitaanniemi, S., Tiihonen, A. M., Lehtipuro, S., Kummola, L., Raulamo, E., Nordfors, K., Haapasalo, H., Rauhala, M., Kesseli, J., Nykter, M., Haapasalo, J. & Rautajoki, K., 3 Jan 2025, In: Cancer Immunology, Immunotherapy. 74, 2, 63.

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2024

Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors

Pekkarinen, M., Nordfors, K., Uusi-Mäkelä, J., Kytölä, V., Hartewig, A., Huhtala, L., Rauhala, M., Urhonen, H., Häyrynen, S., Afyounian, E., Yli-Harja, O., Zhang, W., Helen, P., Lohi, O., Haapasalo, H., Haapasalo, J., Nykter, M., Kesseli, J. & Rautajoki, K. J., 2024, In: Life science alliance. 7, 6, 18 p., e202302088.

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Early rhombic lip Protogenin^+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma

Visvanathan, A., Saulnier, O., Chen, C., Haldipur, P., Orisme, W., Delaidelli, A., Shin, S., Millman, J., Bryant, A., Abeysundara, N., Wu, X., Hendrikse, L. D., Patil, V., Bashardanesh, Z., Golser, J., Livingston, B. G., Nakashima, T., Funakoshi, Y., Ong, W. & Rasnitsyn, A. & 44 others, Aldinger, K. A., Richman, C. M., Van Ommeren, R., Lee, J. J. Y., Ly, M., Vladoiu, M. C., Kharas, K., Balin, P., Erickson, A. W., Fong, V., Zhang, J., Suárez, R. A., Wang, H., Huang, N., Pallota, J. G., Douglas, T., Haapasalo, J., Razavi, F., Silvestri, E., Sirbu, O., Worme, S., Kameda-Smith, M. M., Wu, X., Daniels, C., MichaelRaj, A. K., Bhaduri, A., Schramek, D., Suzuki, H., Garzia, L., Ahmed, N., Kleinman, C. L., Stein, L. D., Dirks, P., Dunham, C., Jabado, N., Rich, J. N., Li, W., Sorensen, P. H., Wechsler-Reya, R. J., Weiss, W. A., Millen, K. J., Ellison, D. W., Dimitrov, D. S. & Taylor, M. D., 2024, In: Cell. 187, 17, p. 4733-4750.e26 18 p.

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3 Citations (Scopus)

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High angular resolution diffusion-weighted imaging and higher order tractography of the white matter tracts in the anterior thalamic area: Insights into deep brain stimulation targeting

Özdemir, R., Lehtimäki, K., Siitama, E., Möttönen, T., Haapasalo, J., Järvenpää, S., Eskola, H. & Peltola, J., Jun 2024, In: Neuroimage: Reports. 4, 3, 11 p., 100210.

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Motor dysfunction as a primary symptom predicts poor outcome: multicenter study of glioma symptoms

Kivioja, T., Posti, J. P., Sipilä, J., Rauhala, M., Frantzén, J., Gardberg, M., Rahi, M., Rautajoki, K., Nykter, M., Vuorinen, V., Nordfors, K., Haapasalo, H. & Haapasalo, J., 2024, In: Frontiers in Oncology. 13, 1305725.

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Patient-derived glioma organoids real time identification of IDH mutation, 1p/19q-codeletion and CDKN2A/B homozygous deletion with differential ion mobility spectrometry

Hermelo, I., Haapala, I., Mäkelä, M., Jacome Sanz, D., Kontunen, A., Karjalainen, M., Müller, P., Lehtimäki, K., Nykter, M., Frösén, J., Haapasalo, H., Roine, A., Oksala, N., Nordfors, K., Vehkaoja, A. & Haapasalo, J., 2024, (E-pub ahead of print) In: Journal of Neuro-Oncology.

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Rapid identification of pediatric brain tumors with differential mobility spectrometry

Haapala, I., Rauhameri, A., Mäkelä, M., Karjalainen, M., Kontunen, A., Mieskolainen, M., Haapasalo, H., Roine, A., Oksala, N., Vehkaoja, A., Haapasalo, J. & Nordfors, K., 30 Apr 2024, In: Frontiers in Oncology. 14, p. 1-8

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2 Citations (Scopus)

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2023

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting

Rautajoki, K. J., Jaatinen, S., Hartewig, A., Tiihonen, A. M., Annala, M., Salonen, I., Valkonen, M., Simola, V., Vuorinen, E. M., Kivinen, A., Rauhala, M. J., Nurminen, R., Maass, K. K., Lahtela, S. L., Jukkola, A., Yli-Harja, O., Helén, P., Pajtler, K. W., Ruusuvuori, P. & Haapasalo, J. & 3 others, Zhang, W., Haapasalo, H. & Nykter, M., Nov 2023, In: Acta Neuropathologica Communications. 11, 1, 20 p., 176.

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5 Citations (Scopus)

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Impact of Timing of Surgery and Adjuvant Treatment on Survival of Adult IDH–wild-type Glioblastoma: A Single-center Study of 392 Patients

Natukka, T., Haapasalo, J., Kivioja, T., Rajala, L., Raitanen, J., Nevalainen, J., Lahtela, S.-L., Nordfors, K., Rauhala, M., Jukkola, A., Frösen, J., Helén, P., Auvinen, A. & Haapasalo, H., 2023, In: WORLD NEUROSURGERY. 177, p. e785-e792 8 p.

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Impedance Characteristics of Stimulation Contacts in Deep Brain Stimulation of the Anterior Nucleus of the Thalamus and Its Relationship to Seizure Outcome in Patients With Refractory Epilepsy

Möttönen, T., Peltola, J., Järvenpää, S., Haapasalo, J. & Lehtimäki, K., Dec 2023, In: NEUROMODULATION. 26, 8, p. 1733-1741 9 p.

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3 Citations (Scopus)

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2022

Method for the Intraoperative Detection of IDH Mutation in Gliomas with Differential Mobility Spectrometry

Haapala, I., Rauhameri, A., Roine, A., Mäkelä, M., Kontunen, A., Karjalainen, M., Laakso, A., Koroknay-Pál, P., Nordfors, K., Haapasalo, H., Oksala, N., Vehkaoja, A. & Haapasalo, J., May 2022, In: CURRENT ONCOLOGY. 29, 5, p. 3252-3258 7 p.

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8 Citations (Scopus)

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PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas

Rautajoki, K. J., Jaatinen, S., Tiihonen, A. M., Annala, M., Vuorinen, E. M., Kivinen, A., Rauhala, M. J., Maass, K. K., Pajtler, K. W., Yli-Harja, O., Helén, P., Haapasalo, J., Haapasalo, H., Zhang, W. & Nykter, M., 18 Aug 2022, In: Scientific Reports. 12, 14083.

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6 Citations (Scopus)

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2020

Circadian Distribution of Autostimulations in rVNS Therapy in Patients With Refractory Focal Epilepsy

Kulju, T., Verner, R., Dibué-Adjei, M., Eronen, A., Rainesalo, S., Lehtimäki, K., Haapasalo, J. & Peltola, J., 2020, In: Epilepsy & Behavior. 110, p. 107144

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4 Citations (Scopus)

Frequency of Automatic Stimulations in Responsive Vagal Nerve Stimulation in Patients With Refractory Epilepsy

Kulju, T., Haapasalo, J., Verner, R., Dibue-Adjei, M., Lehtimäki, K., Rainesalo, S. & Peltola, J., 2020, In: Neuromodulation. 23, 6, p. 852-858

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6 Citations (Scopus)

MK2 inhibition induces p53-dependent senescence in glioblastoma cells

Phoa, A. F., Recasens, A., Gurgis, F. M. S., Betts, T. A., Menezes, S. V., Chau, D., Nordfors, K., Haapasalo, J., Haapasalo, H., Johns, T. G., Stringer, B. W., Day, B. W., Buckland, M. E., Lalaoui, N. & Munoz, L., 2020, In: Cancers. 12, 3, p. 654 654.

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7 Citations (Scopus)

2019

Autostimulation in Vagus Nerve Stimulator Treatment: Modulating Neuromodulation

Kulju, T., Haapasalo, J., Rainesalo, S., Lehtimäki, K. & Peltola, J., 2019, In: Neuromodulation. 22, 5, p. 630-637

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9 Citations (Scopus)

Identifying brain tumors by differential mobility spectrometry analysis of diathermy smoke

Haapala, I., Karjalainen, M., Kontunen, A., Vehkaoja, A., Nordfors, K., Haapasalo, H., Haapasalo, J., Oksala, N. & Roine, A., 2019, In: Journal of Neurosurgery. 7 p.

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13 Citations (Scopus)

2018

Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors

Karjalainen, S. L., Haapasalo, H. K., Aspatwar, A., Barker, H., Parkkila, S. & Haapasalo, J. A., 2018, In: BMC Cancer. 18, 1, p. 584 584.

Research output: Contribution to journal › Article › Scientific › peer-review

15 Citations (Scopus)

NRF2, DJ1 and SNRX1 and their prognostic impact in astrocytic gliomas

Haapasalo, J., Nordfors, K., Granberg, K., Kivioja, T., Nykter, M., Haapasalo, H. & Soini, Y., 2018, In: Histology and Histopathology. 33, 8, p. 791-801

Research output: Contribution to journal › Article › Scientific › peer-review

18 Citations (Scopus)

Similarities between the responses to ANT-DBS and prior VNS in refractory epilepsy

Kulju, T., Haapasalo, J., Lehtimäki, K., Rainesalo, S. & Peltola, J., 2018, In: Brain and Behavior. 8, 6, p. e00983 e00983.

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29 Citations (Scopus)

Whole-exome sequencing identifies germline mutation in TP53 and ATRX in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma

Nordfors, K., Haapasalo, J., Ebrahim, A., Afyounian, E., Tuominen, J., Annala, M., Häyrynen, S., Karhu, R., Helén, P., Lohi, O., Nykter, M., Haapasalo, H. & Granberg, K. J., Mar 2018, In: Cold Spring Harbor Molecular Case Studies. 4, 2, 13 p., a002246.

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6 Citations (Scopus)

2017

Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas

Granberg, K., Annala, M., Lehtinen, B., Kesseli, J., Haapasalo, J., Ruusuvuori, P., Yli-Harja, O., Visakorpi, T., Haapasalo, H., Nykter, M. & Zhang, W., 2017, In: Neuro-Oncology. 19, 9, p. 1206-1216 11 p.

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30 Citations (Scopus)

Successful management of super-refractory status epilepticus with thalamic deep brain stimulation

Lehtimäki, K., Långsjö, J. W., Ollikainen, J., Heinonen, H., Möttönen, T., Tähtinen, T., Haapasalo, J., Tenhunen, J., Katisko, J., Öhman, J. & Peltola, J., 2017, In: ANNALS OF NEUROLOGY. 81, 1, p. 142-146

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40 Citations (Scopus)

Vagus nerve stimulation improves working memory performance

Sun, L., Peräkylä, J., Holm, K., Haapasalo, J., Lehtimäki, K., Ogawa, K., Peltola, J. & Hartikainen, K., 2017, In: JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY. 39, 10, p. 954-964

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94 Citations (Scopus)

2016

Imaging of Anterior Nucleus of Thalamus Using 1.5T MRI for Deep Brain Stimulation Targeting in Refractory Epilepsy

Jiltsova, E., Möttönen, T., Fahlström, M., Haapasalo, J., Tähtinen, T., Peltola, J., Öhman, J., Larsson, E.-M., Kiekara, T. & Lehtimäki, K., 2016, In: Neuromodulation. 19, 8, p. 812-817

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34 Citations (Scopus)

Outcome based definition of the anterior thalamic deep brain stimulation target in refractory epilepsy

Lehtimäki, K., Möttönen, T., Järventausta, K., Katisko, J., Tähtinen, T., Haapasalo, J., Niskakangas, T., Kiekara, T., Öhman, J. & Peltola, J., 2016, In: BRAIN STIMULATION. 9, 2, p. 268-275

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108 Citations (Scopus)

The Correlation between Intraoperative Microelectrode Recording and 3-Tesla MRI in Patients Undergoing ANT-DBS for Refractory Epilepsy

Möttönen, T., Katisko, J., Haapasalo, J., Tähtinen, T., Saastamoinen, A., Peltola, J., Öhman, J. & Lehtimäki, K., 2016, In: STEREOTACTIC AND FUNCTIONAL NEUROSURGERY. 94, 2, p. 86-92

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15 Citations (Scopus)

2015

Defining the anterior nucleus of the thalamus (ANT) as a deep brain stimulation target in refractory epilepsy: Delineation using 3 T MRI and intraoperative microelectrode recording

Möttönen, T., Katisko, J., Haapasalo, J., Tähtinen, T., Kiekara, T., Kähärä, V., Peltola, J., Öhman, J. & Lehtimäki, K., 2015, In: NeuroImage: Clinical. 7, p. 823-829 7 p.

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85 Citations (Scopus)

The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1ß-driven IL-6 secretion in glioblastoma cells

Gurgis, F., Yeung, Y., Tang, M., Heng, B., Buckland, M., Ammit, A., Haapasalo, J. & Haapasalo, H., 2015, In: Oncogene. 34, 22, p. 2934-42

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63 Citations (Scopus)

Twist predicts poor outcome of patients with astrocytic glioma

Nordfors, K., Haapasalo, J., Mäkelä, K., Granberg, K. J., Nykter, M., Korja, M., Paavonen, T., Haapasalo, H. & Soini, Y., 2015, In: Journal of Clinical Pathology. 68, 11, p. 905-912 8 p.

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22 Citations (Scopus)

2014

Hsp27 and its expression pattern in diffusely infiltrating astrocytomas

Mäkelä, K. S., Haapasalo, J. A., Ilvesaro, J. M., Parkkila, S., Paavonen, T. & Haapasalo, H. K., 2014, In: Histology and Histopathology. 29, 9, p. 1161-1168

Research output: Contribution to journal › Article › Scientific › peer-review

6 Citations (Scopus)

Immediate effects of deep brain stimulation of anterior thalamic nuclei on executive functions and emotion-attention interaction in humans

Hartikainen, K. M., Sun, L., Polvivaara, M., Brause, M., Lehtimäki, K., Haapasalo, J., Möttönen, T., Väyrynen, K., Ogawa, K. H., Öhman, J. & Peltola, J., 2014, In: JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY. 36, 5, p. 540-550 11 p.

Research output: Contribution to journal › Article › Scientific › peer-review

67 Citations (Scopus)

Polysialic acid is associated with better prognosis and IDH1-mutation in diffusely infiltrating astrocytomas

Mäkelä, K., Nordfors, K., Finne, J., Jokilammi, A., Paavonen, T., Haapasalo, H., Korja, M. & Haapasalo, J., 2014, In: BMC Cancer. 14, 623, 623.

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

2013

Expression of claudins relates to tumour aggressivity, location and recurrence in ependymomas

Nordfors, K., Haapasalo, J., Sallinen, P., Haapasalo, H. & Soini, Y., 2013, In: Histology and Histopathology. 28, 9, p. 1137-1146

Research output: Contribution to journal › Article › Scientific › peer-review

6 Citations (Scopus)

2011

Carbonic anhydrase VII-a potential prognostic marker in gliomas

Bootorabi, F., Haapasalo, J., Smith, E., Haapasalo, H. & Parkkila, S., 2011, In: HEALTH. 3, 1, p. 6-12

Research output: Contribution to journal › Article › Scientific › peer-review

2010

The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis

Nordfors, K., Haapasalo, J., Korja, M., Niemelä, A., Laine, J., Parkkila, A., Pastorekova, S., Pastorek, J., Waheed, A., Sly, W., Parkkila, S. & Haapasalo, H., 2010, In: BMC Cancer. 10, p. 148

Research output: Contribution to journal › Article › Scientific › peer-review

62 Citations (Scopus)

2009

Expression of iron-related genes in human brain and brain tumors

Hänninen, M., Haapasalo, J., Haapasalo, H., Fleming, R., Britton, R., Bacon, B. & Parkkila, S., 2009, In: BMC Neurosci. 10, p. 36

Research output: Contribution to journal › Article › Scientific › peer-review

77 Citations (Scopus)

2008

Decreased expression of antioxidant enzymes is associated with aggressive features in ependymomas

Järvelä, S., Haapasalo, H., Nordfors, K., Jansson, M., Haapasalo, J., Helen, P., Paljärvi, L., Kalimo, H., Kinnula, V. & Soini, Y., 2008, In: Journal of Neuro-Oncology. 90, 3, p. 283-291

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas

Haapasalo, J., Hilvo, M., Nordfors, K., Haapasalo, H., Parkkila, S., Hyrskyluoto, A., Rantala, I., Waheed, A., Sly, W., Pastorekova, S., Pastorek, J. & Parkkila, A., 2008, In: Neuro Oncol.. 10, 2, p. 131-138

Research output: Contribution to journal › Article › Scientific › peer-review

80 Citations (Scopus)

2007

Carbonic anhydrase II in the endothelium of glial tumors: a potential target for therapy

Haapasalo, J., Nordfors, K., Järvelä, S., Braggge, H., Rantala, I., Parkkila, A.-K., Haapasalo, H. & Parkkila, S., 2007, In: Neuro-oncol. 9, 3, p. 308-313

Research output: Contribution to journal › Article › Scientific › peer-review

65 Citations (Scopus)

Peroxiredoxins and antioxidant enzymes in pilocytic astrocytomas

Nordfors, K., Haapasalo, J., Helen, Paetau, A., Paljärvi, L., Kalimo, H., Kinnula, V., Soini, Y., Haapasalo, H. & Helén, P., 2007, In: Clin neuropathol. 26, 5, p. 210-218

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15 Citations (Scopus)

2006

Amplification of the epidermal growth factor receptor in astrocytic tumours by chromogenic in situ hybridization: association with clinicopathological features and patient survival

Järvelä, S., Helin, H., Haapasalo, J., Järvelä, T., Junttila, T., Elenius, K., Tanner, M., Haapasalo, H. & Isola, J., 2006, In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. 32, 4, p. 441-450

Research output: Contribution to journal › Article › Scientific › peer-review

34 Citations (Scopus)

Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis

Haapasalo, J., Nordfors, K., Hilvo, M., Rantala, I., Soini, Y., Parkkila, A., Pastorekova, S., Pastorek, J., Parkkila, S. & Haapasalo, H., 2006, In: Clin Cancer Res. 12, 2, p. 473-477

Research output: Contribution to journal › Article › Scientific › peer-review

122 Citations (Scopus)

Joonas Haapasalo

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