No photo of Leo-Pekka Lyytikäinen

Leo-Pekka Lyytikäinen

20062024

Research activity per year

Filter
Article

Search results

  • 2024

    Accumulation of Lewy-Related Pathology Starts in Middle Age: The Tampere Sudden Death Study

    Kok, E. H., Paetau, A., Martiskainen, M., Lyytikäinen, L. P., Lehtimäki, T., Karhunen, P. & Myllykangas, L., 2024, (E-pub ahead of print) In: ANNALS OF NEUROLOGY. 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    5 Downloads (Pure)
  • Polygenic risk for schizophrenia, social dispositions, and pace of epigenetic aging: Results from the Young Finns Study

    Saarinen, A., Marttila, S., Mishra, P. P., Lyytikäinen, L-P., Raitoharju, E., Mononen, N., Sormunen, E., Kähönen, M., Raitakari, O., Hietala, J., Keltikangas-Järvinen, L. & Lehtimäki, T., Mar 2024, In: AGING CELL. 23, 3, e14052.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    3 Downloads (Pure)
  • Open Access
    File
  • Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes

    Early Growth Genetics Consortium, Bradfield, J. P., Kember, R. L., Ulrich, A., Balkiyarova, Z., Alyass, A., Aris, I. M., Bell, J. A., Broadaway, K. A., Chen, Z., Chai, J. F., Davies, N. M., Fernandez-Orth, D., Bustamante, M., Fore, R., Ganguli, A., Heiskala, A., Hottenga, J. J., Íñiguez, C., Kobes, S., & 31 othersLeinonen, J., Lowry, E., Lyytikainen, L. P., Mahajan, A., Pitkänen, N., Schnurr, T. M., Have, C. T., Strachan, D. P., Thiering, E., Vogelezang, S., Wade, K. H., Wang, C. A., Wong, A., Holm, L. A., Chesi, A., Choong, C., Cruz, M., Elliott, P., Franks, S., Frithioff-Bøjsøe, C., Gauderman, W. J., Glessner, J. T., Gilsanz, V., Griesman, K., Hanson, R. L., Kähönen, M., Mononen, N., Eriksson, J. G., Lehtimäki, T., Mykkänen, J. & Shepherd, J. A., 16 Jan 2024, In: Genome biology. 25, 1, 22.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    1 Downloads (Pure)
  • X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements

    Scholz, M., Horn, K., Pott, J., Wuttke, M., Kühnapfel, A., Nasr, M. K., Kirsten, H., Li, Y., Hoppmann, A., Gorski, M., Ghasemi, S., Li, M., Tin, A., Chai, J-F., Cocca, M., Wang, J., Nutile, T., Akiyama, M., Åsvold, B. O., Bansal, N., & 139 othersBiggs, M. L., Boutin, T., Brenner, H., Brumpton, B., Burkhardt, R., Cai, J., Campbell, A., Campbell, H., Chalmers, J., Chasman, D. I., Chee, M. L., Chee, M. L., Chen, X., Cheng, C-Y., Cifkova, R., Daviglus, M., Delgado, G., Dittrich, K., Edwards, T. L., Endlich, K., Michael Gaziano, J., Giri, A., Giulianini, F., Gordon, S. D., Gudbjartsson, D. F., Hallan, S., Hamet, P., Hartman, C. A., Hayward, C., Heid, I. M., Hellwege, J. N., Holleczek, B., Holm, H., Hutri-Kähönen, N., Hveem, K., Isermann, B., Jonas, J. B., Joshi, P. K., Kamatani, Y., Kanai, M., Kastarinen, M., Khor, C. C., Kiess, W., Kleber, M. E., Körner, A., Kovacs, P., Krajcoviechova, A., Kramer, H., Krämer, B. K., Kuokkanen, M., Kähönen, M., Lange, L. A., Lash, J. P., Lehtimäki, T., Li, H., Lin, B. M., Liu, J., Loeffler, M., Lyytikäinen, L-P., Magnusson, P. K. E., Martin, N. G., Matsuda, K., Milaneschi, Y., Mishra, P. P., Mononen, N., Montgomery, G. W., Mook-Kanamori, D. O., Mychaleckyj, J. C., März, W., Nauck, M., Nikus, K., Nolte, I. M., Noordam, R., Okada, Y., Olafsson, I., Oldehinkel, A. J., Penninx, B. W. J. H., Perola, M., Pirastu, N., Polasek, O., Porteous, D. J., Poulain, T., Psaty, B. M., Rabelink, T. J., Raffield, L. M., Raitakari, O. T., Rasheed, H., Reilly, D. F., Rice, K. M., Richmond, A., Ridker, P. M., Rotter, J. I., Rudan, I., Sabanayagam, C., Salomaa, V., Schneiderman, N., Schöttker, B., Sims, M., Snieder, H., Stark, K. J., Stefansson, K., Stocker, H., Stumvoll, M., Sulem, P., Sveinbjornsson, G., Svensson, P. O., Tai, E-S., Taylor, K. D., Tayo, B. O., Teren, A., Tham, Y-C., Thiery, J., Thio, C. H. L., Thomas, L. F., Tremblay, J., Tönjes, A., van der Most, P. J., Vitart, V., Völker, U., Wang, Y. X., Wang, C., Wei, W. B., Whitfield, J. B., Wild, S. H., Wilson, J. F., Winkler, T. W., Wong, T-Y., Woodward, M., Sim, X., Chu, A. Y., Feitosa, M. F., Thorsteinsdottir, U., Hung, A. M., Teumer, A., Franceschini, N., Parsa, A., Köttgen, A., Schlosser, P. & Pattaro, C., 18 Jan 2024, In: Nature Communications. 15, 1, 586.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    1 Downloads (Pure)
  • 2023

    Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

    de las Fuentes, L., Schwander, K. L., Brown, M. R., Bentley, A. R., Winkler, T. W., Sung, Y. J., Munroe, P. B., Miller, C. L., Aschard, H., Aslibekyan, S., Bartz, T. M., Bielak, L. F., Chai, J. F., Cheng, C. Y., Dorajoo, R., Feitosa, M. F., Guo, X., Hartwig, F. P., Horimoto, A., Kolčić, I., & 178 othersLim, E., Liu, Y., Manning, A. K., Marten, J., Musani, S. K., Noordam, R., Padmanabhan, S., Rankinen, T., Richard, M. A., Ridker, P. M., Smith, A. V., Vojinovic, D., Zonderman, A. B., Alver, M., Boissel, M., Christensen, K., Freedman, B. I., Gao, C., Giulianini, F., Harris, S. E., He, M., Hsu, F. C., Kühnel, B., Laguzzi, F., Li, X., Lyytikäinen, L-P., Nolte, I. M., Poveda, A., Rauramaa, R., Riaz, M., Robino, A., Sofer, T., Takeuchi, F., Tayo, B. O., van der Most, P. J., Verweij, N., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Zhan, Y., Amin, N., Arking, D. E., Ballantyne, C., Boerwinkle, E., Brody, J. A., Broeckel, U., Campbell, A., Canouil, M., Chai, X., Chen, Y. D. I., Chen, X., Chitrala, K. N., Concas, M. P., de Faire, U., de Mutsert, R., de Silva, H. J., de Vries, P. S., Do, A., Faul, J. D., Fisher, V., Floyd, J. S., Forrester, T., Friedlander, Y., Girotto, G., Gu, C. C., Hallmans, G., Heikkinen, S., Heng, C. K., Homuth, G., Hunt, S., Ikram, M. A., Jacobs, D. R., Kavousi, M., Khor, C. C., Kilpeläinen, T. O., Koh, W. P., Komulainen, P., Langefeld, C. D., Liang, J., Liu, K., Liu, J., Lohman, K., Mägi, R., Manichaikul, A. W., McKenzie, C. A., Meitinger, T., Milaneschi, Y., Nauck, M., Nelson, C. P., O’Connell, J. R., Palmer, N. D., Pereira, A. C., Perls, T., Peters, A., Polašek, O., Raitakari, O. T., Rice, K., Rice, T. K., Rich, S. S., Sabanayagam, C., Schreiner, P. J., Shu, X. O., Sidney, S., Sims, M., Smith, J. A., Starr, J. M., Strauch, K., Tai, E. S., Taylor, K. D., Tsai, M. Y., Uitterlinden, A. G., van Heemst, D., Waldenberger, M., Wang, Y. X., Wei, W. B., Wilson, G., Xuan, D., Yao, J., Yu, C., Yuan, J. M., Zhao, W., Becker, D. M., Bonnefond, A., Bowden, D. W., Cooper, R. S., Deary, I. J., Divers, J., Esko, T., Franks, P. W., Froguel, P., Gieger, C., Jonas, J. B., Kato, N., Lakka, T. A., Leander, K., Lehtimäki, T., Magnusson, P. K. E., North, K. E., Ntalla, I., Penninx, B., Samani, N. J., Snieder, H., Spedicati, B., van der Harst, P., Völzke, H., Wagenknecht, L. E., Weir, D. R., Wojczynski, M. K., Wu, T., Zheng, W., Zhu, X., Bouchard, C., Chasman, D. I., Evans, M. K., Fox, E. R., Gudnason, V., Hayward, C., Horta, B. L., Kardia, S. L. R., Krieger, J. E., Mook-Kanamori, D. O., Peyser, P. A., Province, M. M., Psaty, B. M., Rudan, I., Sim, X., Smith, B. H., van Dam, R. M., van Duijn, C. M., Wong, T. Y., Arnett, D. K., Rao, D. C., Gauderman, J., Liu, C. T., Morrison, A. C., Rotter, J. I. & Fornage, M., 2023, In: Frontiers in Genetics. 14, 16 p., 1235337.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    6 Downloads (Pure)
  • Genetic insights into resting heart rate and its role in cardiovascular disease

    The DCCT/EDIC Research Group, van de Vegte, Y. J., Eppinga, R. N., van der Ende, M. Y., Hagemeijer, Y. P., Mahendran, Y., Salfati, E., Smith, A. V., Tan, V. Y., Arking, D. E., Ntalla, I., Appel, E. V., Schurmann, C., Brody, J. A., Rueedi, R., Polasek, O., Sveinbjornsson, G., Lecoeur, C., Ladenvall, C., Zhao, J. H., & 31 othersIsaacs, A., Wang, L., Luan, J., Hwang, S. J., Mononen, N., Auro, K., Jackson, A. U., Bielak, L. F., Zeng, L., Shah, N., Nethander, M., Campbell, A., Rankinen, T., Pechlivanis, S., Qi, L., Zhao, W., Rizzi, F., Tanaka, T., Robino, A., Cocca, M., Lange, L., Müller-Nurasyid, M., Roselli, C., Zhang, W., Kleber, M. E., Guo, X., Lyytikäinen, L. P., Nikus, K., Kähönen, M., Eriksson, J. G. & Lehtimäki, T., Aug 2023, In: Nature Communications. 14, 21 p., 4646.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    1 Downloads (Pure)
  • Genetic Risk Scores Associated with Temperament Clusters in Finnish Depression Patients

    Salminen, S-P., Solismaa, A., Lyytikäinen, L-P., Paavonen, V., Mononen, N., Lehtimäki, T., Leinonen, E. & Kampman, O., 2023, (E-pub ahead of print) In: ACTA NEUROPSYCHIATRICA. 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  • Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

    Kavousi, M., Bos, M. M., Barnes, H. J., Lino Cardenas, C. L., Wong, D., Lu, H., Hodonsky, C. J., Landsmeer, L. P. L., Turner, A. W., Kho, M., Hasbani, N. R., de Vries, P. S., Bowden, D. W., Chopade, S., Deelen, J., Benavente, E. D., Guo, X., Hofer, E., Hwang, S. J., Lutz, S. M., & 69 othersLyytikäinen, L. P., Slenders, L., Smith, A. V., Stanislawski, M. A., van Setten, J., Wong, Q., Yanek, L. R., Becker, D. M., Beekman, M., Budoff, M. J., Feitosa, M. F., Finan, C., Hilliard, A. T., Kardia, S. L. R., Kovacic, J. C., Kral, B. G., Langefeld, C. D., Launer, L. J., Malik, S., Hoesein, F. A. A. M., Mokry, M., Schmidt, R., Smith, J. A., Taylor, K. D., Terry, J. G., van der Grond, J., van Meurs, J., Vliegenthart, R., Xu, J., Young, K. A., Zilhão, N. R., Zweiker, R., Assimes, T. L., Becker, L. C., Bos, D., Carr, J. J., Cupples, L. A., de Kleijn, D. P. V., de Winther, M., den Ruijter, H. M., Fornage, M., Freedman, B. I., Gudnason, V., Hingorani, A. D., Hokanson, J. E., Ikram, M. A., Išgum, I., Jacobs, D. R., Kähönen, M., Lange, L. A., Lehtimäki, T., Pasterkamp, G., Raitakari, O. T., Schmidt, H., Slagboom, P. E., Uitterlinden, A. G., Vernooij, M. W., Bis, J. C., Franceschini, N., Psaty, B. M., Post, W. S., Rotter, J. I., Björkegren, J. L. M., O’Donnell, C. J., Bielak, L. F., Peyser, P. A., Malhotra, R., van der Laan, S. W. & Miller, C. L., 2023, In: Nature Genetics. 55, 10, p. 1651-1664 14 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
  • Polygenic liabilities underlying job stress and exhaustion over a 10-year follow-up: A general population study

    Saarinen, A., Hietala, J., Lyytikäinen, L. P., Hamal Mishra, B., Sormunen, E., Kähönen, M., Rovio, S., Viikari, J., Raitakari, O., Lehtimäki, T. & Keltikangas-Järvinen, L., Aug 2023, In: PSYCHIATRY RESEARCH. 326, 115355.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    9 Downloads (Pure)
  • Polygenic risk for schizophrenia predicting social trajectories in a general population sample

    Saarinen, A., Hietala, J., Lyytikäinen, L-P., Hamal Mishra, B., Sormunen, E., Lavonius, V., Kähönen, M., Raitakari, O., Lehtimäki, T. & Keltikangas-Järvinen, L., 4 Dec 2023, (E-pub ahead of print) In: Psychological Medicine.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
  • Rare variant analyses across multiethnic cohorts identify novel genes for refractive error

    Musolf, A. M., Haarman, A. E. G., Luben, R. N., Ong, J. S., Patasova, K., Trapero, R. H., Marsh, J., Jain, I., Jain, R., Wang, P. Z., Lewis, D. D., Tedja, M. S., Li, H., Cowan, C. S., Consortium for Refractive Error and Myopia (CREAM), Biino, G., Klein, A. P., Duggal, P., Mackey, D. A., Hayward, C., & 15 othersHaller, T., Metspalu, A., Wedenoja, J., Pärssinen, O., Ching-Yu, C., Saw, S. M., Stambolian, D., Hysi, P. G., Khawaja, A. P., Vitart, V., Hammond, C. J., van Dujin, C. M., Verhoeven, V. J. M., Klaver, C. C. W. & Bailey-Wilson, J. E., Jan 2023, In: Communications biology. 6, 6.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
  • Uncovering the complex genetic architecture of human plasma lipidome using machine learning methods

    Lehtimäki, M., H. Mishra, B., Del-Val, C., Lyytikäinen, L. P., Kähönen, M., Cloninger, C. R., Raitakari, O. T., Laaksonen, R., Zwir, I., Lehtimäki, T. & Mishra, P. P., Feb 2023, In: Scientific Reports. 13, 1, 3078.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    3 Downloads (Pure)
  • 2022

    A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

    Million Veterans Program, Global Lipids Genetics Consortium, Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., & 32 othersHui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Rosenthal, E. A., Hutri-Kähönen, N., Lyytikäinen, L. P., Nikus, K., Kovacs, P., Kähönen, M., Lehtimäki, T., Tuomilehto, J., Kuusisto, J. & Abbas, S., 4 Aug 2022, In: AMERICAN JOURNAL OF HUMAN GENETICS. 109, 8, p. 1366-1387 22 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    7 Downloads (Pure)
  • A saturated map of common genetic variants associated with human height

    23andMe Research Team, VA Million Veteran Program, DiscovEHR (DiscovEHR and MyCode Community Health Initiative), eMERGE (Electronic Medical Records and Genomics Network), Lifelines cohort study, The PRACTICAL Consortium, Understanding Society Scientific Group, Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., & 37 othersMukamel, R. E., Spracklen, C. N., Yin, X., Chen, S. H., Ferreira, T., Highland, H. H., Ji, Y., Karaderi, T., Lin, K., Lüll, K., Malden, D. E., Medina-Gomez, C., Machado, M., Moore, A., Rüeger, S., Sim, X., Vrieze, S., Ahluwalia, T. S., Akiyama, M., Allison, M. A., Alvarez, M., Andersen, M. K., Ani, A., Appadurai, V., Arbeeva, L., Bhaskar, S., Bielak, L. F., Bollepalli, S., Bonnycastle, L. L., Bork-Jensen, J., Bradfield, J. P., Hansen, T. F., Lyytikäinen, L. P., Mishra, P. P., Kähönen, M., Lehtimäki, T. & Tuomilehto, J., 2022, In: Nature. 610, p. 704–712 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    1 Citation (Scopus)
    2 Downloads (Pure)
  • Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis

    Schillemans, T., Tragante, V., Maitusong, B., Gigante, B., Cresci, S., Laguzzi, F., Vikström, M., Richards, M., Pilbrow, A., Cameron, V., Foco, L., Doughty, R. N., Kuukasjärvi, P., Allayee, H., Hartiala, J. A., Tang, W. H. W., Lyytikäinen, L. P., Nikus, K., Laurikka, J. O., Srinivasan, S., & 37 othersMordi, I. R., Trompet, S., Kraaijeveld, A., van Setten, J., Gijsberts, C. M., Maitland-van der Zee, A. H., Saely, C. H., Gong, Y., Johnson, J. A., Cooper-DeHoff, R. M., Pepine, C. J., Casu, G., Leiherer, A., Drexel, H., Horne, B. D., van der Laan, S. W., Marziliano, N., Hazen, S. L., Sinisalo, J., Kähönen, M., Lehtimäki, T., Lang, C. C., Burkhardt, R., Scholz, M., Jukema, J. W., Eriksson, N., Åkerblom, A., James, S., Held, C., Hagström, E., Spertus, J. A., Algra, A., de Faire, U., Åkesson, A., Asselbergs, F. W., Patel, R. S. & Leander, K., 23 Jun 2022, In: Frontiers in Physiology. 13, 14 p., 909870.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    1 Downloads (Pure)
  • C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis

    Park, I., Goddard, M. E., Cole, J. E., Zanin, N., Lyytikäinen, L-P., Lehtimäki, T., Andreakos, E., Feldmann, M., Udalova, I., Drozdov, I. & Monaco, C., 11 Jan 2022, In: Nature Communications. 13, 17 p., 215.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    21 Downloads (Pure)
  • Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

    Lifelines cohort study, DiscovEHR/MyCode study, VA Million Veteran Program, Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., Thomas, L. F., Tin, A., Hoppmann, A., Chu, A. Y., Tayo, B., Thio, C. H. L., Cusi, D., Chai, J. F., Sieber, K. B., Horn, K., Li, M., & 33 othersScholz, M., Cocca, M., Wuttke, M., van der Most, P. J., Yang, Q., Ghasemi, S., Nutile, T., Li, Y., Pontali, G., Günther, F., Dehghan, A., Correa, A., Parsa, A., Feresin, A., de Vries, A. P. J., Zonderman, A. B., Smith, A. V., Oldehinkel, A. J., De Grandi, A., Rosenkranz, A. R., Franke, A., Teren, A., Metspalu, A., Hicks, A. A., Kuusisto, J., Nikus, K., Lyytikäinen, L. P., Kähönen, M., Hutri-Kähönen, N., Mononen, N., Mishra, P. P., Kovacs, P. & Lehtimäki, T., Jun 2022, In: Communications biology. 5, 20 p., 580.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    3 Downloads (Pure)
  • Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

    Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T. V., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J. W., Haessler, J., Lyytikäinen, L. P., Repetto, L., Concas, M. P., van den Berg, M. E., Weiss, S., Baldassari, A. R., Bartz, T. M., Cook, J. P., Evans, D. S., & 146 othersFreudling, R., Hines, O., Isaksen, J. L., Lin, H., Mei, H., Moscati, A., Müller-Nurasyid, M., Nursyifa, C., Qian, Y., Richmond, A., Roselli, C., Ryan, K. A., Tarazona-Santos, E., Thériault, S., van Duijvenboden, S., Warren, H. R., Yao, J., Raza, D., Aeschbacher, S., Ahlberg, G., Alonso, A., Andreasen, L., Bis, J. C., Boerwinkle, E., Campbell, A., Catamo, E., Cocca, M., Cutler, M. J., Darbar, D., De Grandi, A., De Luca, A., Ding, J., Ellervik, C., Ellinor, P. T., Felix, S. B., Froguel, P., Fuchsberger, C., Gögele, M., Graff, C., Graff, M., Guo, X., Hansen, T., Heckbert, S. R., Huang, P. L., Huikuri, H. V., Hutri-Kähönen, N., Ikram, M. A., Jackson, R. D., Junttila, J., Kavousi, M., Kors, J. A., Leal, T. P., Lemaitre, R. N., Lin, H. J., Lind, L., Linneberg, A., Liu, S., MacFarlane, P. W., Mangino, M., Meitinger, T., Mezzavilla, M., Mishra, P. P., Mitchell, R. N., Mononen, N., Montasser, M. E., Morrison, A. C., Nauck, M., Nauffal, V., Navarro, P., Nikus, K., Pare, G., Patton, K. K., Pelliccione, G., Pittman, A., Porteous, D. J., Pramstaller, P. P., Preuss, M. H., Raitakari, O. T., Reiner, A. P., Ribeiro, A. L. P., Rice, K. M., Risch, L., Schlessinger, D., Schotten, U., Schurmann, C., Shen, X., Shoemaker, M. B., Sinagra, G., Sinner, M. F., Soliman, E. Z., Stoll, M., Strauch, K., Tarasov, K., Taylor, K. D., Tinker, A., Trompet, S., Uitterlinden, A., Völker, U., Völzke, H., Waldenberger, M., Weng, L. C., Whitsel, E. A., Wilson, J. G., Avery, C. L., Conen, D., Correa, A., Cucca, F., Dörr, M., Gharib, S. A., Girotto, G., Grarup, N., Hayward, C., Jamshidi, Y., Järvelin, M. R., Jukema, J. W., Kääb, S., Kähönen, M., Kanters, J. K., Kooperberg, C., Lehtimäki, T., Lima-Costa, M. F., Liu, Y., Loos, R. J. F., Lubitz, S. A., Mook-Kanamori, D. O., Morris, A. P., O'Connell, J. R., Olesen, M. S., Orini, M., Padmanabhan, S., Pattaro, C., Peters, A., Psaty, B. M., Rotter, J. I., Stricker, B., van der Harst, P., van Duijn, C. M., Verweij, N., Wilson, J. F., Arking, D. E., Ramirez, J., Lambiase, P. D., Sotoodehnia, N., Mifsud, B., Newton-Cheh, C. & Munroe, P. B., Sept 2022, In: Nature Communications. 13, 18 p., 5144.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    54 Downloads (Pure)
  • Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

    Gorski, M., Rasheed, H., Teumer, A., Thomas, L. F., Graham, S. E., Sveinbjornsson, G., Winkler, T. W., Günther, F., Stark, K. J., Chai, J. F., Tayo, B. O., Wuttke, M., Li, Y., Tin, A., Ahluwalia, T. S., Ärnlöv, J., Åsvold, B. O., Bakker, S. J. L., Banas, B., Bansal, N., & 30 othersBiggs, M. L., Biino, G., Böhnke, M., Boerwinkle, E., Bottinger, E. P., Brenner, H., Brumpton, B., Carroll, R. J., Chaker, L., Chalmers, J., Chee, M. L., Chee, M. L., Cheng, C. Y., Chu, A. Y., Ciullo, M., Cocca, M., Cook, J. P., Coresh, J., Cusi, D., de Borst, M. H., Degenhardt, F., Eckardt, K. U., Hutri-Kähönen, N., Kähönen, M., Kuusisto, J., Lehtimäki, T., Lyytikäinen, L. P., Mishra, P. P., Mononen, N. & Nikus, K., 2022, In: KIDNEY INTERNATIONAL. 102, 3, p. 624-639 16 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    16 Downloads (Pure)
  • Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

    Lifelines cohort study, Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E., Feenstra, B., & 31 othersFeitosa, M. F., Gieger, C., Graff, M., Hall, L. M., Haller, T., Hartwig, F. P., Hillis, D. A., Huikari, V., Heard-Costa, N., Holzapfel, C., Jackson, A. U., Johansson, Å., Jørgensen, A. M., Kaakinen, M. A., Karlsson, R., Kerr, K. F., Kim, B., Koolhaas, C. M., Kutalik, Z., Lagou, V., Lind, P. A., Lorentzon, M., Lyytikäinen, L. P., Mangino, M., Metzendorf, C., Monroe, K. R., Pacolet, A., Pérusse, L., Kähönen, M., Kuusisto, J. & Lehtimäki, T., 2022, In: Nature Genetics. 54, p. 1332-1344 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    5 Downloads (Pure)
  • High-risk ECG patterns in ST elevation myocardial infarction for mortality prediction

    Lahti, R., Rankinen, J., Lyytikäinen, L. P., Eskola, M., Nikus, K. & Hernesniemi, J., 2022, In: Journal of Electrocardiology. 74, p. 13-19 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    17 Downloads (Pure)
  • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

    Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K-H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C., & 519 othersThorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Rosenthal, E. A., Lingren, T., Feng, Q., Kullo, I. J., Narita, A., Takayama, J., Martin, H. C., Hunt, K. A., Trivedi, B., Haessler, J., Giulianini, F., Bradford, Y., Miller, J. E., Campbell, A., Lin, K., Millwood, I. Y., Rasheed, A., Hindy, G., Faul, J. D., Zhao, W., Weir, D. R., Turman, C., Huang, H., Graff, M., Choudhury, A., Sengupta, D., Mahajan, A., Brown, M. R., Zhang, W., Yu, K., Schmidt, E. M., Pandit, A., Gustafsson, S., Yin, X., Luan, J., Zhao, J-H., Matsuda, F., Jang, H-M., Yoon, K., Medina-Gomez, C., Pitsillides, A., Hottenga, J. J., Wood, A. R., Ji, Y., Gao, Z., Haworth, S., Yousri, N. A., Mitchell, R. E., Chai, J. F., Aadahl, M., Bjerregaard, A. A., Yao, J., Manichaikul, A., Hwu, C-M., Hung, Y-J., Warren, H. R., Ramirez, J., Bork-Jensen, J., Kårhus, L. L., Goel, A., Sabater-Lleal, M., Noordam, R., Mauro, P., Matteo, F., McDaid, A. F., Marques-Vidal, P., Wielscher, M., Trompet, S., Sattar, N., Møllehave, L. T., Munz, M., Zeng, L., Huang, J., Yang, B., Poveda, A., Kurbasic, A., Lamina, C., Forer, L., Scholz, M., Galesloot, T. E., Bradfield, J. P., Ruotsalainen, S. E., Daw, EW., Zmuda, J. M., Mitchell, J. S., Fuchsberger, C., Christensen, H., Brody, J. A., Vazquez-Moreno, M., Feitosa, M. F., Wojczynski, M. K., Wang, Z., Preuss, M. H., Mangino, M., Christofidou, P., Verweij, N., Benjamins, J. W., Engmann, J., Tsao, N. L., Verma, A., Slieker, R. C., Lo, K. S., Zilhao, N. R., Le, P., Kleber, M. E., Delgado, G. E., Huo, S., Ikeda, D. D., Iha, H., Yang, J., Liu, J., Demirkan, A., Leonard, H. L., Marten, J., Frank, M., Schmidt, B., Smyth, L. J., Cañadas-Garre, M., Wang, C., Nakatochi, M., Wong, A., Hutri-Kähönen, N., Sim, X., Xia, R., Huerta-Chagoya, A., Fernandez-Lopez, J. C., Lyssenko, V., Nongmaithem, S. S., Bayyana, S., Stringham, H. M., Irvin, M. R., Oldmeadow, C., Kim, H-N., Ryu, S., Timmers, P. R. H. J., Arbeeva, L., Dorajoo, R., Lange, L. A., Prasad, G., Lorés-Motta, L., Pauper, M., Long, J., Li, X., Theusch, E., Takeuchi, F., Spracklen, C. N., Loukola, A., Bollepalli, S., Warner, S. C., Wang, Y. X., Wei, W. B., Nutile, T., Ruggiero, D., Sung, Y. J., Chen, S., Liu, F., Yang, J., Kentistou, K. A., Banas, B., Nardone, G. G., Meidtner, K., Bielak, L. F., Smith, J. A., Hebbar, P., Farmaki, A-E., Hofer, E., Lin, M., Concas, M. P., Vaccargiu, S., van der Most, P. J., Pitkänen, N., Cade, B. E., van der Laan, S. W., Chitrala, K. N., Weiss, S., Bentley, A. R., Doumatey, A. P., Adeyemo, A. A., Lee, J. Y., Petersen, E. R. B., Nielsen, A. A., Choi, H. S., Nethander, M., Freitag-Wolf, S., Southam, L., Rayner, N. W., Wang, C. A., Lin, S-Y., Wang, J-S., Couture, C., Lyytikäinen, L-P., Nikus, K., Cuellar-Partida, G., Vestergaard, H., Hidalgo, B., Giannakopoulou, O., Cai, Q., Obura, M. O., van Setten, J., Li, X., Liang, J., Tang, H., Terzikhan, N., Shin, J. H., Jackson, R. D., Reiner, A. P., Martin, L. W., Chen, Z., Li, L., Kawaguchi, T., Thiery, J., Bis, J. C., Launer, L. J., Li, H., Nalls, M. A., Raitakari, O. T., Ichihara, S., Wild, S. H., Nelson, C. P., Campbell, H., Jäger, S., Nabika, T., Al-Mulla, F., Niinikoski, H., Braund, P. S., Kolcic, I., Kovacs, P., Giardoglou, T., Katsuya, T., de Kleijn, D., de Borst, G. J., Kim, E. K., Adams, H. H. H., Ikram, M. A., Zhu, X., Asselbergs, F. W., Kraaijeveld, A. O., Beulens, J. W. J., Shu, X-O., Rallidis, L. S., Pedersen, O., Hansen, T., Mitchell, P., Hewitt, A. W., Kähönen, M., Pérusse, L., Bouchard, C., Tönjes, A., Chen, Y-D. I., Pennell, C. E., Mori, T. A., Lieb, W., Franke, A., Ohlsson, C., Mellström, D., Cho, Y. S., Lee, H., Yuan, J-M., Koh, W-P., Rhee, S. Y., Woo, J-T., Heid, I. M., Stark, K. J., Zimmermann, M. E., Völzke, H., Homuth, G., Evans, M. K., Zonderman, A. B., Polasek, O., Pasterkamp, G., Hoefer, I. E., Redline, S., Pahkala, K., Oldehinkel, A. J., Snieder, H., Biino, G., Schmidt, R., Schmidt, H., Bandinelli, S., Dedoussis, G., Thanaraj, T. A., Kardia, S. L. R., Peyser, P. A., Kato, N., Schulze, M. B., Girotto, G., Böger, C. A., Jung, B., Joshi, P. K., Bennett, D. A., De Jager, P. L., Lu, X., Mamakou, V., Brown, M., Caulfield, M. J., Munroe, P. B., Guo, X., Ciullo, M., Jonas, J. B., Samani, N. J., Kaprio, J., Pajukanta, P., Tusié-Luna, T., Aguilar-Salinas, C. A., Adair, L. S., Bechayda, S. A., de Silva, H. J., Wickremasinghe, A. R., Krauss, R. M., Wu, J-Y., Zheng, W., Hollander, A. I., Bharadwaj, D., Correa, A., Wilson, J. G., Lind, L., Heng, C-K., Nelson, A. E., Golightly, Y. M., Wilson, J. F., Penninx, B., Kim, H-L., Attia, J., Scott, R. J., Rao, D. C., Arnett, D. K., Hunt, S. C., Walker, M., Koistinen, H. A., Chandak, G. R., Mercader, J. M., Costanzo, M. C., Jang, D., Burtt, N. P., Villalpando, C. G., Orozco, L., Fornage, M., Tai, ES., van Dam, R. M., Lehtimäki, T., Chaturvedi, N., Yokota, M., Liu, J., Reilly, D. F., McKnight, A. J., Kee, F., Jöckel, K-H., McCarthy, M. I., Palmer, C. N. A., Vitart, V., Hayward, C., Simonsick, E., van Duijn, C. M., Jin, Z-B., Qu, J., Hishigaki, H., Lin, X., März, W., Gudnason, V., Tardif, J-C., Lettre, G., Hart, L. M. ., Elders, P. J. M., Damrauer, S. M., Kumari, M., Kivimaki, M., van der Harst, P., Spector, T. D., Loos, R. J. F., Province, M. A., Parra, E. J., Cruz, M., Psaty, B. M., Brandslund, I., Pramstaller, P. P., Rotimi, C. N., Christensen, K., Ripatti, S., Widén, E., Hakonarson, H., Grant, S. F. A., Kiemeney, L. A. L. M., de Graaf, J., Loeffler, M., Kronenberg, F., Gu, D., Erdmann, J., Schunkert, H., Franks, P. W., Linneberg, A., Jukema, J. W., Khera, A. V., Männikkö, M., Jarvelin, M-R., Kutalik, Z., Francesco, C., Mook-Kanamori, D. O., van Dijk, K. W., Watkins, H., Strachan, D. P., Grarup, N., Sever, P., Poulter, N., Chuang, L-M., Rotter, J. I., Dantoft, T. M., Karpe, F., Neville, M. J., Timpson, N. J., Cheng, C-Y., Wong, T-Y., Khor, C. C., Li, H., Sabanayagam, C., Peters, A., Gieger, C., Hattersley, A. T., Pedersen, N. L., Magnusson, P. K. E., Boomsma, D. I., Willemsen, A. H. M., Cupples, LA., van Meurs, J. B. J., Ghanbari, M., Gordon-Larsen, P., Huang, W., Kim, Y. J., Tabara, Y., Wareham, N. J., Langenberg, C., Zeggini, E., Kuusisto, J., Laakso, M., Ingelsson, E., Abecasis, G., Chambers, J. C., Kooner, J. S., de Vries, P. S., Morrison, A. C., Hazelhurst, S., Ramsay, M., North, K. E., Daviglus, M., Kraft, P., Martin, N. G., Whitfield, J. B., Abbas, S., Saleheen, D., Walters, R. G., Holmes, M. V., Black, C., Smith, B. H., Baras, A., Justice, A. E., Buring, J. E., Ridker, P. M., Chasman, D. I., Kooperberg, C., Tamiya, G., Yamamoto, M., van Heel, D. A., Trembath, R. C., Wei, W-Q., Jarvik, G. P., Namjou, B., Hayes, M. G., Ritchie, M. D., Jousilahti, P., Salomaa, V., Hveem, K., Åsvold, B. O., Kubo, M., Kamatani, Y., Okada, Y., Murakami, Y., Kim, B-J., Thorsteinsdottir, U., Stefansson, K., Zhang, J., Chen, YE., Ho, Y-L., Lynch, J. A., Rader, D. J., Tsao, P. S., Chang, K-M., Cho, K., O'Donnell, C. J., Gaziano, J. M., Wilson, P. W. F., Frayling, T. M., Hirschhorn, J. N., Kathiresan, S., Mohlke, K. L., Sun, Y. V., Morris, A. P., Boehnke, M., Brown, C. D., Natarajan, P., Deloukas, P., Willer, C. J., Assimes, T. L. & Peloso, G. M., 27 Dec 2022, In: Genome Biology. 23, 1, 42 p., 268.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    2 Downloads (Pure)
  • Interatrial block and P terminal force in the general population: Longitudinal changes, risk factors and prognosis

    Istolahti, T., Eranti, A., Huhtala, H., Tynkkynen, J., Lyytikäinen, L. P., Kähönen, M., Lehtimäki, T., Eskola, M., Anttila, I., Jula, A., Nikus, K. & Hernesniemi, J., 2022, In: Journal of Electrocardiology. 73, p. 12-20 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    14 Downloads (Pure)
  • Long-term tracking and population characteristics of lipoprotein (a) in the Cardiovascular Risk in Young Finns Study

    Raitakari, O., Kivelä, A., Pahkala, K., Rovio, S., Mykkänen, J., Ahola-Olli, A., Loo, B. M., Lyytikäinen, L. P., Lehtimäki, T., Kähönen, M., Juonala, M., Rönnemaa, T., Lamina, C., Kronenberg, F. & Viikari, J., Sept 2022, In: Atherosclerosis. 356, p. 18-27 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    10 Downloads (Pure)
  • Magical thinking in individuals with high polygenic risk for schizophrenia but no non-affective psychoses: a general population study

    Saarinen, A., Lyytikäinen, L. P., Hietala, J., Dobewall, H., Lavonius, V., Raitakari, O., Kähönen, M., Sormunen, E., Lehtimäki, T. & Keltikangas-Järvinen, L., 2022, In: MOLECULAR PSYCHIATRY. 27, 8, p. 3286–3293 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    8 Downloads (Pure)
  • Mitochondrial genome-wide analysis of nuclear DNA methylation quantitative trait loci

    Laaksonen, J., Mishra, P. P., Seppälä, I., Raitoharju, E., Marttila, S., Mononen, N., Lyytikäinen, L-P., Kleber, M. E., Delgado, G. E., Lepistö, M., Almusa, H., Ellonen, P., Lorkowski, S., März, W., Hutri-Kähönen, N., Raitakari, O., Kähönen, M., Salonen, J. T. & Lehtimäki, T., 2022, In: Human Molecular Genetics. 31, 10, p. 1720–1732

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    2 Downloads (Pure)
  • Prevalence and long-term prognostic implications of prolonged QRS duration in left ventricular hypertrophy: a population-based observational cohort study

    Rankinen, J., Haataja, P., Lyytikäinen, L. P., Huhtala, H., Lehtimäki, T., Kähönen, M., Eskola, M., Tuohinen, S., Pérez-Riera, A. R., Jula, A., Rissanen, H., Nikus, K. & Hernesniemi, J., 28 Feb 2022, In: BMJ Open. 12, 8 p., e053477.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    5 Downloads (Pure)
  • The S1S2S3 electrocardiographic pattern — Prevalence and relation to cardiovascular and pulmonary diseases in the general population

    Nurminen, J., Pérez-Riera, A. R., de Luna, A. B., Nikus, K., Lyytikäinen, L. P., Huhtala, H., Eskola, M., Kähönen, M., Jula, A., Lehtimäki, T. & Hernesniemi, J., Jul 2022, In: Journal of Electrocardiology. 73, p. 113-119 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    759 Downloads (Pure)
  • 2021

    Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health

    Marttila, S., Rovio, S., Mishra, P. P., Seppälä, I., Lyytikäinen, L. P., Juonala, M., Waldenberger, M., Oksala, N., Ala-Korpela, M., Harville, E., Hutri-Kähönen, N., Kähönen, M., Raitakari, O., Lehtimäki, T. & Raitoharju, E., Apr 2021, In: Scientific Reports. 11, 1, 9203.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    12 Downloads (Pure)
  • Assessment of plasma ceramides as predictor for subclinical atherosclerosis

    Mishra, P. P., Mishra, B. H., Lyytikäinen, L. P., Hilvo, M., Juonala, M., Kähönen, M., Hutri-Kähönen, N., Fotiadis, D. I., Raitakari, O. T., Laaksonen, R. & Lehtimäki, T., Nov 2021, In: Atherosclerosis Plus. 45, p. 25-31 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    13 Downloads (Pure)
  • Examining the effect of mitochondrial DNA variants on blood pressure in two Finnish cohorts

    Laaksonen, J., Mishra, P. P., Seppälä, I., Lyytikäinen, L-P., Raitoharju, E., Mononen, N., Lepistö, M., Almusa, H., Ellonen, P., Hutri-Kähönen, N., Juonala, M., Raitakari, O., Kähönen, M., Salonen, J. T. & Lehtimäki, T., 2021, In: Scientific Reports. 11, 1, 611.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    3 Downloads (Pure)
  • Functional Polymorphisms in Oxytocin and Dopamine Pathway Genes and the Development of Dispositional Compassion Over Time: The Young Finns Study

    Dobewall, H., Saarinen, A., Lyytikäinen, L. P., Keltikangas-Järvinen, L., Lehtimäki, T. & Hintsanen, M., 2021, In: Frontiers in Psychology. 12, 576346.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    4 Downloads (Pure)
  • Genetic differential susceptibility to the parent–child relationship quality and the life span development of compassion

    Dobewall, H., Keltikangas-Järvinen, L., Saarinen, A., Lyytikäinen, L. P., Zwir, I., Cloninger, R., Raitakari, O. T., Lehtimäki, T. & Hintsanen, M., 2021, In: DEVELOPMENTAL PSYCHOBIOLOGY. 63, 6, e22184.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    33 Downloads (Pure)
  • Genome-wide analysis identifies novel susceptibility loci for myocardial infarction

    Hartiala, J. A., Han, Y., Jia, Q., Hilser, J. R., Huang, P., Gukasyan, J., Schwartzman, W. S., Cai, Z., Biswas, S., Trégouët, D. A., Smith, N. L., INVENT Consortium, CHARGE Consortium Hemostasis Working Group, GENIUS-CHD Consortium, Seldin, M., Pan, C., Mehrabian, M., Lusis, A. J., Bazeley, P., Sun, Y. V., & 34 othersLiu, C., Quyyumi, A. A., Scholz, M., Thiery, J., Delgado, G. E., Kleber, M. E., März, W., Howe, L. J., Asselbergs, F. W., van Vugt, M., Vlachojannis, G. J., Patel, R. S., Lyytikäinen, L. P., Kähönen, M., Lehtimäki, T., Nieminen, T. V. M., Kuukasjärvi, P., Laurikka, J. O., Chang, X., Heng, C. K., Jiang, R., Kraus, W. E., Hauser, E. R., Ferguson, J. F., Reilly, M. P., Ito, K., Koyama, S., Kamatani, Y., Komuro, I., Biobank Japan, Stolze, L. K., Romanoski, C. E., Khan, M. D. & Turner, A. W., 2021, In: European Heart Journal. 42, 9, p. 919-933 15 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    2 Citations (Scopus)
    24 Downloads (Pure)
  • Impedance plethysmography-based method in the assessment of subclinical atherosclerosis

    Haapala, M., Lyytikäinen, L-P., Peltokangas, M., Koivistoinen, T., Hutri-Kähönen, N., Laurila, M-M., Mäntysalo, M., Raitakari, O. T., Kähönen, M., Lehtimäki, T., Vehkaoja, A. & Oksala, N., 2021, In: Atherosclerosis. 319, p. 101-107 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    21 Downloads (Pure)
  • Long-term outcome of intraventricular conduction delays in the general population

    Rankinen, J., Haataja, P., Lyytikäinen, L-P., Huhtala, H., Lehtimäki, T., Kähönen, M., Eskola, M., Pérez-Riera, A. R., Jula, A., Rissanen, H., Nikus, K. & Hernesniemi, J., 2021, In: ANNALS OF NONINVASIVE ELECTROCARDIOLOGY. 26, 1, e12788.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    2 Citations (Scopus)
    16 Downloads (Pure)
  • Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

    Lifelines cohort study, Gorski, M., Jung, B., Li, Y., Matias-Garcia, P. R., Wuttke, M., Coassin, S., Thio, C. H. L., Kleber, M. E., Winkler, T. W., Wanner, V., Chai, J-F., Chu, A. Y., Cocca, M., Feitosa, M. F., Ghasemi, S., Hoppmann, A., Horn, K., Li, M., Nutile, T., & 31 othersScholz, M., Sieber, K. B., Teumer, A., Tin, A., Wang, J., Tayo, B. O., Ahluwalia, T. S., Almgren, P., Bakker, S. J. L., Banas, B., Bansal, N., Biggs, M. L., Boerwinkle, E., Bottinger, E. P., Brenner, H., Carroll, R. J., Chalmers, J., Chee, M-L., Chee, M-L., Cheng, C-Y., Coresh, J., de Borst, M. H., Degenhardt, F., Eckardt, K-U., Hutri-Kähönen, N., Kähönen, M., Lehtimäki, T., Lyytikäinen, L-P., Mishra, P. P., Mononen, N. & Nikus, K., 1 Apr 2021, In: KIDNEY INTERNATIONAL. 99, 4, p. 926-939

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    1 Citation (Scopus)
    1 Downloads (Pure)
  • Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs

    Marttila, S., Viiri, L. E., Mishra, P. P., Kühnel, B., Matias-Garcia, P. R., Lyytikäinen, L. P., Ceder, T., Mononen, N., Rathmann, W., Winkelmann, J., Peters, A., Kähönen, M., Hutri-Kähönen, N., Juonala, M., Aalto-Setälä, K., Raitakari, O., Lehtimäki, T., Waldenberger, M. & Raitoharju, E., Jul 2021, In: Clinical Epigenetics. 13, 143.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    14 Downloads (Pure)
  • Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

    Lifelines cohort study, Sun, D., Richard, M. A., Musani, S. K., Sung, Y. J., Winkler, T. W., Schwander, K., Chai, J. F., Guo, X., Kilpeläinen, T. O., Vojinovic, D., Aschard, H., Bartz, T. M., Bielak, L. F., Brown, M. R., Chitrala, K., Hartwig, F. P., Horimoto, A. R. V. R., Liu, Y., Manning, A. K., & 31 othersNoordam, R., Smith, A. V., Harris, S. E., Kühnel, B., Lyytikäinen, L. P., Nolte, I. M., Rauramaa, R., van der Most, P. J., Wang, R., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Arking, D. E., Arnett, D. K., Barac, A., Boerwinkle, E., Broeckel, U., Chakravarti, A., Chen, Y. D. I., Cupples, L. A., Davigulus, M. L., de las Fuentes, L., de Mutsert, R., de Vries, P. S., Delaney, J. A. C., Diez Roux, A. V., Dörr, M., Faul, J. D., Fretts, A. M. & Lehtimäki, T., 2021, In: Human Genetics and Genomics Advances. 2, 1, 100013.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
  • Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure

    Wang, H., Noordam, R., Cade, B. E., Schwander, K., Winkler, T. W., Lee, J., Sung, Y. J., Bentley, A. R., Manning, A. K., Aschard, H., Kilpeläinen, T. O., Ilkov, M., Brown, M. R., Horimoto, A. R., Richard, M., Bartz, T. M., Vojinovic, D., Lim, E., Nierenberg, J. L., Liu, Y., & 105 othersChitrala, K., Rankinen, T., Musani, S. K., Franceschini, N., Rauramaa, R., Alver, M., Zee, P. C., Harris, S. E., van der Most, P. J., Nolte, I. M., Munroe, P. B., Palmer, N. D., Kühnel, B., Weiss, S., Wen, W., Hall, K. A., Lyytikäinen, L. P., O’Connell, J., Eiriksdottir, G., Launer, L. J., de Vries, P. S., Arking, D. E., Chen, H., Boerwinkle, E., Krieger, J. E., Schreiner, P. J., Sidney, S., Shikany, J. M., Rice, K., Chen, Y. D. I., Gharib, S. A., Bis, J. C., Luik, A. I., Ikram, M. A., Uitterlinden, A. G., Amin, N., Xu, H., Levy, D., He, J., Lohman, K. K., Zonderman, A. B., Rice, T. K., Sims, M., Wilson, G., Sofer, T., Rich, S. S., Palmas, W., Yao, J., Guo, X., Rotter, J. I., Biermasz, N. R., Mook-Kanamori, D. O., Martin, L. W., Barac, A., Wallace, R. B., Gottlieb, D. J., Komulainen, P., Heikkinen, S., Mägi, R., Milani, L., Metspalu, A., Starr, J. M., Milaneschi, Y., Waken, R. J., Gao, C., Waldenberger, M., Peters, A., Strauch, K., Meitinger, T., Roenneberg, T., Völker, U., Dörr, M., Shu, X. O., Mukherjee, S., Hillman, D. R., Kähönen, M., Wagenknecht, L. E., Gieger, C., Grabe, H. J., Zheng, W., Palmer, L. J., Lehtimäki, T., Gudnason, V., Morrison, A. C., Pereira, A. C., Fornage, M., Psaty, B. M., van Duijn, C. M., Liu, C. T., Kelly, T. N., Evans, M. K., Bouchard, C., Fox, E. R., Kooperberg, C., Zhu, X., Lakka, T. A., Esko, T., North, K. E., Deary, I. J., Snieder, H., Penninx, B. W. J. H., Gauderman, W. J., Rao, D. C., Redline, S. & van Heemst, D., 15 Apr 2021, In: MOLECULAR PSYCHIATRY. 26, 11

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    2 Downloads (Pure)
  • Prehospital Adenosine Diphosphate Receptor Blocker Use, Culprit Artery Flow, and Mortality in STEMI: The MADDEC Study

    Hautamäki, M., Lyytikäinen, L-P., Eskola, M., Lehtimäki, T., Nikus, K., Oksala, N., Tynkkynen, J. & Hernesniemi, J., 2021, In: Clinical Drug Investigation. 41, 7

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    6 Downloads (Pure)
  • The power of genetic diversity in genome-wide association studies of lipids

    VA Million Veteran Program, Global Lipids Genetics Consortium, Graham, S. E., Clarke, S. L., Wu, K-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R., Ekoru, K., & 32 othersVerma, A., Trivedi, B., Martin, H. C., Hunt, K. A., Hui, Q., Klarin, D., Zhu, X., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Ruotsalainen, S. E., Havulinna, A. S., Veturi, Y., Feng, Q., Rosenthal, E. A., Lingren, T., Hutri-Kähönen, N., Lyytikäinen, L-P., Nikus, K., Kovacs, P., Kähönen, M., Lehtimäki, T. & Kuusisto, J., Dec 2021, In: Nature. 600, 7890, p. 675-679 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
  • The prognostic significance of T-wave inversion according to ECG lead group during long-term follow-up in the general population

    Istolahti, T., Lyytikäinen, L-P., Huhtala, H., Nieminen, T., Kähönen, M., Lehtimäki, T., Eskola, M., Anttila, I., Jula, A., Rissanen, H., Nikus, K. & Hernesniemi, J., Jan 2021, In: ANNALS OF NONINVASIVE ELECTROCARDIOLOGY. 26, 1, e12799.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    27 Downloads (Pure)
  • The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease

    Kalaoja, M., Corbin, L. J., Tan, V. Y., Ahola-Olli, A. V., Havulinna, A. S., Santalahti, K., Pitkänen, N., Lehtimäki, T., Lyytikäinen, L. P., Raitoharju, E., Seppälä, I., Kähönen, M., Ripatti, S., Palotie, A., Perola, M., Viikari, J. S., Jalkanen, S., Maksimow, M., Salomaa, V., Salmi, M., & 3 othersRaitakari, O. T., Kettunen, J. & Timpson, N. J., 2021, In: Obesity. 29, 2, p. 428-437 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    2 Citations (Scopus)
    2 Downloads (Pure)
  • Variants associated with HHIP expression have sex-differential effects on lung function

    Fawcett, K. A., Wain, L. V., Obeidat, M., Melbourne, C., Shrine, N., Guyatt, A. L., John, C., Luan, J., Richmond, A., Moksnes, M. R., Granell, R., Weiss, S., Imboden, M., May-Wilson, S., Hysi, P., Boutin, T. S., Portas, L., Flexeder, C., Harris, S. E., Wang, C. A., & 55 othersLyytikäinen, L. P., Palviainen, T., Foong, R. E., Keidel, D., Minelli, C., Langenberg, C., Bossé, Y., Van den Berge, M., Sin, D. D., Hao, K., Campbell, A., Porteous, D., Padmanabhan, S., Smith, B. H., Evans, D. M., Ring, S., Langhammer, A., Hveem, K., Willer, C., Ewert, R., Stubbe, B., Pirastu, N., Klaric, L., Joshi, P. K., Patasova, K., Massimo, M., Polasek, O., Starr, J. M., Karrasch, S., Strauch, K., Meitinger, T., Rudan, I., Rantanen, T., Pietiläinen, K., Kähönen, M., Raitakari, O. T., Hall, G. L., Sly, P. D., Pennell, C. E., Kaprio, J., Lehtimäki, T., Vitart, V., Deary, I. J., Jarvis, D., Wilson, J. F., Spector, T., Probst-Hensch, N., Wareham, N. J., Völzke, H., Henderson, J., Strachan, D. P., Brumpton, B. M., Hayward, C., Hall, I. P. & Tobin, M. D., 2021, In: Wellcome Open Research. 5, 111.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    3 Downloads (Pure)
  • 2020

    Association of Factor V Leiden With Subsequent Atherothrombotic Events : A GENIUS-CHD Study of Individual Participant Data

    Mahmoodi, B., Tragante, V., Kleber, M., Holmes, M., Schmidt, A., McCubrey, R., Howe, L., Direk, K., Allayee, H., Baranova, E., Braund, P., Delgado, G., Eriksson, N., Gijsberts, C., Gong, Y., Hartiala, J., Heydarpour, M., Pasterkamp, G., Kotti, S., Kuukasjärvi, P., & 5 othersKähönen, M., Laurikka, J., Lehtimäki, T., Lyytikäinen, L-P. & Nikus, K., 2020, In: CIRCULATION. 142, 6, p. 546-555

    Research output: Contribution to journalArticleScientificpeer-review

    1 Citation (Scopus)
  • Cardiorespiratory fitness and heart rate recovery predict sudden cardiac death independent of ejection fraction

    Hernesniemi, J. A., Kähönen, M., Sipilä, K., Tikkakoski, A., Tynkkynen, J. T., Mishra, P. P., Lyytikäinen, L. P., Nikus, K., Nieminen, T. & Lehtimäki, T., 2020, In: Heart. 106, 6, p. 434-440

    Research output: Contribution to journalArticleScientificpeer-review

    3 Citations (Scopus)
  • Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

    de las Fuentes, L., Manning, A., Chasman, D. I., Aschard, H., Bartz, T. M., Bielak, L. F., Campbell, A., Cheng, C-Y., Dorajoo, R., Hartwig, F. P., Horimoto, A. R. V. R., Sung, Y. J., Li, C., Lyytikäinen, L-P., Kähönen, M., Lehtimäki, T., Noordam, R., Winkler, T., Feitosa, M. F., Schwander, K., & 3 othersBentley, A. R., Brown, M. R. & Guo, X., 2020, In: MOLECULAR PSYCHIATRY.

    Research output: Contribution to journalArticleScientificpeer-review

    2 Citations (Scopus)
  • Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity

    Yaghootkar, H., Zhang, Y., Spracklen, C. N., Karaderi, T., Huang, L. O., Bradfield, J., Schurmann, C., Fine, R. S., Preuss, M. H., Kutalik, Z., Wittemans, L. B. L., Lu, Y., Metz, S., Willems, S. M., Li-Gao, R., Grarup, N., Wang, S., Molnos, S., Sandoval-Zárate, A. A., Nalls, M. A., & 96 othersLange, L. A., Haesser, J., Guo, X., Lyytikäinen, L. P., Feitosa, M. F., Sitlani, C. M., Venturini, C., Mahajan, A., Kacprowski, T., Wang, C. A., Chasman, D. I., Amin, N., Broer, L., Robertson, N., Young, K. L., Allison, M., Auer, P. L., Blüher, M., Borja, J. B., Bork-Jensen, J., Carrasquilla, G. D., Christofidou, P., Demirkan, A., Doege, C. A., Garcia, M. E., Graff, M., Guo, K., Hakonarson, H., Hong, J., Chen, Y. D. I., Jackson, R., Jakupovic, H., Jousilahti, P., Justice, A. E., Kähönen, M., Kizer, J. R., Kriebel, J., Leduc, C. A., Li, J., Lind, L., Luan, JA., Mackey, D. A., Mangino, M., Männistö, S., Carli, J. F. M., Medina-Gomez, C., Mook-Kanamori, D. O., Morris, A. P., de Mutsert, R., Nauck, M., Prokic, I., Pennell, C. E., Pradhan, A. D., Psaty, B. M., Raitakari, O. T., Scott, R. A., Skaaby, T., Strauch, K., Taylor, K. D., Teumer, A., Uitterlinden, A. G., Wu, Y., Yao, J., Walker, M., North, K. E., Kovacs, P., Ikram, M. A., van Duijn, C. M., Ridker, P. M., Lye, S., Homuth, G., Ingelsson, E., Spector, T. D., McKnight, B., Province, M. A., Lehtimäki, T., Adair, L. S., Rotter, J. I., Reiner, A. P., Wilson, J. G., Harris, T. B., Ripatti, S., Grallert, H., Meigs, J. B., Salomaa, V., Hansen, T., van Dijk, K. W., Wareham, N. J., Grant, S. F. A., Langenberg, C., Frayling, T. M., Lindgren, C. M., Mohlke, K. L., Leibel, R. L., Loos, R. J. F. & Kilpeläinen, T. O., Dec 2020, In: Diabetes. 69, 12, p. 2806-2818 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    1 Citation (Scopus)