Research output per year
Research output per year
- 40 results
Search results
-
2024
Bioprinting of human pluripotent stem cell derived corneal endothelial cells with hydrazone crosslinked hyaluronic acid bioink
Grönroos, P., Mörö, A., Puistola, P., Hopia, K., Huuskonen, M., Viheriälä, T., Ilmarinen, T. & Skottman, H., 14 Mar 2024, In: Stem Cell Research & Therapy. 15, 20 p., 81.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile4 Citations (Scopus)10 Downloads (Pure) -
Deciphering the heterogeneity of differentiating hPSC-derived corneal limbal stem cells through single-cell RNA sequencing
Vattulainen, M., Smits, J. G. A., Arts, J. A., Lima Cunha, D., Ilmarinen, T., Skottman, H. & Zhou, H., 9 Jul 2024, In: Stem Cell Reports. 19, 7, p. 1010-1023 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile8 Downloads (Pure) -
Novel Human Induced Pluripotent Stem Cell-Based Model for Retinal Pigment Epithelial Cells to Reveal Possible Disease Mechanisms for Macular Degeneration in Pseudoxanthoma Elasticum
Viheriälä, T., Hongisto, H., Saari, L., Oksanen, M., Ilmarinen, T., Väärämäki, S., Uusitalo, H., Nevalainen, P. & Skottman, H., 2024, In: JOURNAL OF OPHTHALMOLOGY. 2024, 6939920.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Whole mount immunofluorescence analysis of fresh and stored human donor corneas highlights changes in limbal characteristics during storage
Kauppila, M., Vattulainen, M., Ihalainen, T. O., Mörö, A., Ilmarinen, T. & Skottman, H., Oct 2024, In: OCULAR SURFACE. 34, p. 50-59 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile9 Downloads (Pure) -
2023
Production and limbal lineage commitment of aniridia patient-derived induced pluripotent stem cells
Ilmarinen, T., Vattulainen, M., Kandhavelu, J., Bremond-Gignac, D., Aberdam, D. & Skottman, H., Dec 2023, In: Stem Cells. 41, 12, p. 1133-1141 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile2 Downloads (Pure) -
Toward Corneal Limbus In Vitro Model: Regulation of hPSC-LSC Phenotype by Matrix Stiffness and Topography During Cell Differentiation Process
Kauppila, M., Mörö, A., Valle-Delgado, J. J., Ihalainen, T., Sukki, L., Puistola, P., Kallio, P., Ilmarinen, T., Österberg, M. & Skottman, H., 2023, In: ADVANCED HEALTHCARE MATERIALS. 12, 29, 16 p., 2301396.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile3 Citations (Scopus)9 Downloads (Pure) -
2022
Cell maturation influences the ability of hESC-RPE to tolerate cellular stress
Viheriälä, T., Hongisto, H., Sorvari, J., Skottman, H., Nymark, S. & Ilmarinen, T., Jan 2022, In: Stem Cell Research and Therapy. 13, 15 p., 30.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile6 Citations (Scopus)7 Downloads (Pure) -
2021
Corneal epithelial differentiation of human pluripotent stem cells generates ABCB5+ and ∆Np63α+ cells with limbal cell characteristics and high wound healing capacity
Vattulainen, M., Ilmarinen, T., Viheriälä, T., Jokinen, V. & Skottman, H., Dec 2021, In: Stem Cell Research and Therapy. 12, 609.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile13 Citations (Scopus)14 Downloads (Pure) -
Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE
Viheriälä, T., Sorvari, J., Ihalainen, T. O., Mörö, A., Grönroos, P., Schlie-Wolter, S., Chichkov, B., Skottman, H., Nymark, S. & Ilmarinen, T., 2021, In: Scientific Reports. 11, 1, 933.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile11 Citations (Scopus)11 Downloads (Pure) -
Directed Differentiation of Human Pluripotent Stem Cells towards Corneal Endothelial-Like Cells under Defined Conditions
Grönroos, P., Ilmarinen, T. & Skottman, H., 5 Feb 2021, In: Cells. 10, 2, 331.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile15 Citations (Scopus)44 Downloads (Pure) -
Hints for gentle submacular injection in non-human primates based on intraoperative oct guidance
Tan, G. S. W., Liu, Z., Ilmarinen, T., Barathi, V. A., Chee, C. K., Lingam, G., Su, X. & Stanzel, B. V., Jan 2021, In: Translational Vision Science and Technology. 10, 1, 13 p., 10.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile14 Citations (Scopus)9 Downloads (Pure) -
Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model
Liu, Z., Ilmarinen, T., Tan, G. S. W., Hongisto, H., Wong, E. Y. M., Tsai, A. S. H., Al-Nawaiseh, S., Holder, G. E., Su, X., Barathi, V. A., Skottman, H. & Stanzel, B. V., 2021, In: Stem Cell Research and Therapy. 12, 1, 423.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile13 Citations (Scopus)9 Downloads (Pure) -
2020
Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models
Ramsay, E., Ruponen, M., Subrizi, A., Ravina, M., Sarkhel, S., Hehir, S., Cameron, N. R., Ilmarinen, T., Skottman, H., Kjems, J. & Urtti, A., 2020, In: Pharmaceutics. 12, 7, 667.Research output: Contribution to journal › Article › Scientific › peer-review
7 Citations (Scopus) -
2019
Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation
Szatmári-Tóth, M., Fésüs, L., Petrovski, G., Ilmarinen, T., Mikhailova, A., Skottman, H., Kauppinen, A., Kaarniranta, K., Kristóf, E., Lytvynchuk, L. & Veréb, Z., 2019, In: International Journal of Molecular Sciences. 20, 4, 926.Research output: Contribution to journal › Article › Scientific › peer-review
20 Citations (Scopus) -
Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential
Vattulainen, M., Ilmarinen, T., Koivusalo, L., Viiri, K., Hongisto, H. & Skottman, H., 2019, In: Stem Cell Research & Therapy. 10, 236.Research output: Contribution to journal › Article › Scientific › peer-review
20 Citations (Scopus) -
Tissue adhesive hyaluronic acid hydrogels for sutureless stem cell delivery and regeneration of corneal epithelium and stroma
Koivusalo, L., Kauppila, M., Samanta, S., Parihar, V. S., Ilmarinen, T., Miettinen, S., P. Oommen, O. & Skottman, H., 2019, In: Biomaterials. 225, 119516.Research output: Contribution to journal › Article › Scientific › peer-review
144 Citations (Scopus) -
2018
Efficient and Scalable Directed Differentiation of Clinically Compatible Corneal Limbal Epithelial Stem Cells from Human Pluripotent Stem Cells
Hongisto, H., Vattulainen, M., Ilmarinen, T., Mikhailova, A. & Skottman, H., 2018, In: Journal of Visualized Experiments. 140, e58279.Research output: Contribution to journal › Article › Scientific › peer-review
23 Citations (Scopus) -
Hydrazone crosslinked hyaluronan-based hydrogels for therapeutic delivery of adipose stem cells to treat corneal defects
Koivusalo, L., Karvinen, J., Sorsa, E., Jönkkäri, I., Väliaho, J., Kallio, P., Ilmarinen, T., Miettinen, S., Skottman, H. & Kellomäki, M., 2018, In: Materials Science and Engineering C. 85, p. 68-78 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
49 Citations (Scopus) -
Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits
Ilmarinen, T., Skottman, H., Stanzel, B. V., Thieltges, F., Hongisto, H., Juuti-Uusitalo, K., Koistinen, A., Kaarniranta, K., Brinken, R., Braun, N. & Holz, F. G., 2018, In: Acta Ophthalmologica.Research output: Contribution to journal › Article › Scientific › peer-review
17 Citations (Scopus) -
2017
Comparative proteomic analysis of human embryonic stem cell-derived and primary human retinal pigment epithelium
Hongisto, H., Jylhä, A., Nättinen, J., Rieck, J., Ilmarinen, T., Veréb, Z., Aapola, U., Beuerman, R., Petrovski, G., Uusitalo, H. & Skottman, H., 2017, In: Scientific Reports. 7, 1, p. 6016 6016.Research output: Contribution to journal › Article › Scientific › peer-review
22 Citations (Scopus) -
Langmuir-Schaefer film deposition onto honeycomb porous films for retinal tissue engineering
Ilmarinen, T., Vuorimaa-Laukkanen, E., Talvitie, E., Hakola, H. M., Skottman, H. & Kellomäki, M., 2017, In: Acta Biomaterialia. 54, p. 138-149Research output: Contribution to journal › Article › Scientific › peer-review
34 Citations (Scopus) -
Xeno- and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one method
Hongisto, H., Ilmarinen, T., Vattulainen, M., Mikhailova, A. & Skottman, H., 2017, In: Stem Cell Research & Therapy. 8, 291.Research output: Contribution to journal › Article › Scientific › peer-review
77 Citations (Scopus) -
2016
Honeycomb porous films as permeable scaffold materials for human embryonic stem cell-derived retinal pigment epithelium
Ilmarinen, T., Jongprasitkul, H., Skottman, H. & Kellomäki, M., 2016, In: Journal of Biomedical Materials Research. Part A. 104, 7, p. 1646-1656 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
33 Citations (Scopus) -
Human pluripotent stem cell-derived limbal epithelial stem cells on bioengineered matrices for corneal reconstruction
Mikhailova, A., Ilmarinen, T., Ratnayake, A., Goran, P., Petrovski, G., Uusitalo, H., Skottman, H. & Rafat, M., 2016, In: Experimental Eye Research. 146, 146, p. 26-34Research output: Contribution to journal › Article › Scientific › peer-review
35 Citations (Scopus) -
2015
Comparative proteomics reveals human pluripotent stem cell-derived limbal epithelial stem cells are similar to native ocular surface epithelial cells
Mikhailova, A., Jylhä, A., Rieck, J., Nättinen, J., Ilmarinen, T., Veréb, Z., Aapola, U., Beuerman, R., Petrovski, G., Uusitalo, H., Vereb, Z. & Skottman, H., 2015, In: Scientific Reports. 5, p. 14684 14684.Research output: Contribution to journal › Article › Scientific › peer-review
16 Citations (Scopus) -
Patient-specific induced pluripotent stem cell—derived RPE cells: Understanding the pathogenesis of retinopathy in long-chain 3-hydroxyacyl-CoA dehydrogenase deiciency
Polinati, P. P., Ilmarinen, T., Trokovic, R., Hyotylainen, T., Otonkoski, T., Suomalainen, A., Skottman, H. & Tynitiina, T., 2015, In: Investigative Ophthalmology and Visual Science. 56, 5, p. 3371-3382 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
29 Citations (Scopus) -
Ultrathin Polyimide Membrane as Cell Carrier for Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium
Ilmarinen, T., Hiidenmaa, H., Kööbi, P., Nymark, S., Sorkio, A., Wang, J.-H., Stanzel, B. V., Thieltges, F., Oksala, O. E., Kataja, M., Alajuuma, P., Uusitalo, H. M. T., Skottman, H. & Wang, J., 2015, In: PLoS One. 10, 11, p. e0143669Research output: Contribution to journal › Article › Scientific › peer-review
Open Access54 Citations (Scopus) -
2014
Small-molecule induction promotes corneal epithelial cell differentiation from human induced pluripotent stem cells
Mikhailova, A., Ilmarinen, T., Uusitalo, H. & Skottman, H., 2014, In: Stem Cell Reports. 2, 2, p. 219-231 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
87 Citations (Scopus) -
2013
Comparative analysis of targeted differentiation of human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells reveals variability associated with incomplete transgene silencing in retrovirally derived hiPSCs lines
Toivonen, S., Ojala, M., Hyysalo, A., Ilmarinen, T., Rajala, K., Pekkanen-Mattila, M., Äänismaa, R., Lundin, K., Palgi, J., Weltner, J., Trokovic, R., Silvennoinen, O., Skottman, H., Narkilahti, S., Aalto-Setälä, K. & Otonkoski, T., 2013, In: Stem Cells Translational Medicine. 2, 2, p. 83-93 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
66 Citations (Scopus) -
Towards a defined, serum- and feeder-free culture of stratified human oral mucosal epithelium for ocular surface reconstruction
Ilmarinen, T., Laine, J., Juuti-Uusitalo, K., Numminen, J., Seppänen-Suuronen, R., Uusitalo, H. & Skottman, H., 2013, In: Acta Ophthalmologica. 91, 8, p. 744-750 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
28 Citations (Scopus) -
2012
Generation of hESC-derived retinal pigment epithelium on biopolymer coated polyimide membranes
Subrizi, A., Hiidenmaa, H., Ilmarinen, T., Nymark, S., Dubruel, P., Uusitalo, H., Yliperttula, M., Urtti, A. & Skottman, H., 2012, In: Biomaterials. 33, 32, p. 8047-8054Research output: Contribution to journal › Article › Scientific › peer-review
61 Citations (Scopus) -
Low level of activin A secreted by fibroblast feeder cells accelerates early stage differentiation of retinal pigment epithelial cells from human pluripotent stem cells
Hongisto, H., Mikhailova, A., Hiidenmaa, H., Ilmarinen, T. & Skottman, H., 2012, In: STEM CELL DISCOVERY. 2, 4, p. 180-190 1080037.Research output: Contribution to journal › Article › Scientific › peer-review
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2011
Toward the defined and xeno-free differentiation of functional human pluripotent stem cell-derived retinal pigment epithelial cells
Vaajasaari, H., Ilmarinen, T., Juuti-Uusitalo, K., Rajala, K., Onnela, N., Narkilahti, S., Suuronen, R., Hyttinen, J., Uusitalo, H. & Skottman, H., 2011, In: Molecular Vision. 17, 17, p. 558-575Research output: Contribution to journal › Article › Scientific › peer-review
138 Citations (Scopus) -
2009
Wild-type AIRE cooperates with p63 in HLA class II expression of medullary thymic stromal cells.
Tonooka, A., Kikuchi, T., Sato, N., Kubo, T., Ichimiya, S., Tamura, Y., Ilmarinen, T., Ulmanen, I., Kimura, S., Yokoyama, S. & Takano, Y., 2009, In: Biochemical and Biophysical Research Communications. 379, p. 765-70Research output: Contribution to journal › Article › Scientific › peer-review
9 Citations (Scopus) -
2008
Functional interaction of AIRE with PIAS1 in transcriptional regulation.
Ilmarinen, T., Alakurtti, K., Palvimo, J. J., Ulmanen, I., Kangas, H., Kytömaa, T., Eskelin, P., Saharinen, J., Seeler, J., Tanhuanpää, K., Chan, F. Y. L. & Slattery, R. M., 2008, In: MOLECULAR IMMUNOLOGY. 45, p. 1847-62Research output: Contribution to journal › Article › Scientific › peer-review
31 Citations (Scopus) -
2006
Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients.
the FinnDiane Study Group., 2006, In: IMMUNOGENETICS. 58, p. 331-8Research output: Contribution to journal › Article › Scientific › peer-review
40 Citations (Scopus) -
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in the Irish population.
Dominguez, M., Ulmanen, I., Murphy, N., Costigan, C., Crushell, E., Ilmarinen, T., McGovern, E., Collins, S., Chang, B., Fleming, P., Irvine, A. D. & Brosnahan, D., 2006, In: JOURNAL OF PEDIATRIC ENDOCRINOLOGY AND METABOLISM. 19, p. 1343-52Research output: Contribution to journal › Article › Scientific › peer-review
55 Citations (Scopus) -
Dermatological manifestations of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome.
Collins, S., Dominguez, M., Ilmarinen, T., Costigan, C. & Irvine, A. D., 2006, In: British Journal of Dermatology. 154, p. 1088-93Research output: Contribution to journal › Article › Scientific › peer-review
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2005
Functional analysis of SAND mutations in AIRE supports dominant inheritance of the G228W mutation.
Ilmarinen, T., Eskelin, P., Halonen, M., Rüppell, T., Kilpikari, R., Duran, T. G., Kangas, H. & Ulmanen, I., 2005, In: HUMAN MUTATION. 26, p. 322-331Research output: Contribution to journal › Article › Scientific › peer-review
45 Citations (Scopus) -
2004
APECED-causing mutations in AIRE reveal the functional domains of the protein.
Halonen, M., Kangas, H., Rüppell, T., Ilmarinen, T., Ollila, J., Kolmer, M., Vihinen, M., Palvimo, J., Saarela, J., Ulmanen, I. & Eskelin, P., 2004, In: HUMAN MUTATION. 23, p. 245-257Research output: Contribution to journal › Article › Scientific › peer-review
99 Citations (Scopus)