Teemu Tolonen

2024

Expected impact of MRI-targeted biopsy interreader variability among uropathologists on ProScreen prostate cancer screening trial: a pre-trial validation study

Hietikko, R., Mirtti, T., Kilpeläinen, T. P., Tolonen, T., Räisänen-Sokolowski, A., Nordling, S., Hannus, J., Laurila, M., Taari, K., Tammela, T. L. J., Autio, R., Natunen, K., Auvinen, A. & Rannikko, A., 2024, In: WORLD JOURNAL OF UROLOGY. 42, 1, 7 p., 217.

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Prostate Cancer Screening with PSA, Kallikrein Panel, and MRI: The ProScreen Randomized Trial

Auvinen, A., Tammela, T. L. J., Mirtti, T., Lilja, H., Tolonen, T., Kenttämies, A., Rinta-Kiikka, I., Lehtimäki, T., Natunen, K., Nevalainen, J., Raitanen, J., Ronkainen, J., Van Der Kwast, T., Riikonen, J., Pétas, A., Matikainen, M., Taari, K., Kilpeläinen, T. & Rannikko, A. S., 2024, In: JAMA. 331, 17, p. 1452-1459 8 p.

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8 Citations (Scopus)

2023

Breast density and the likelihood of malignant MRI-detected lesions in women diagnosed with breast cancer

Sassi, A., Salminen, A., Jukkola, A., Tervo, M., Mäenpää, N., Turtiainen, S., Tiainen, L., Liimatainen, T., Tolonen, T., Huhtala, H., Rinta-Kiikka, I. & Arponen, O., 2023, In: European Radiology. 33, p. 8080–8088 9 p.

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2 Citations (Scopus)

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Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine

Nurminen, A., Jaatinen, S., Taavitsainen, S., Högnäs, G., Lesluyes, T., Ansari-Pour, N., Tolonen, T., Haase, K., Koskenalho, A., Kankainen, M., Jasu, J., Rauhala, H., Kesäniemi, J., Nikupaavola, T., Kujala, P., Rinta-Kiikka, I., Riikonen, J., Kaipia, A., Murtola, T. & Tammela, T. L. & 5 others, Visakorpi, T., Nykter, M., Wedge, D. C., Van Loo, P. & Bova, G. S., Oct 2023, In: Genome Medicine. 15, 15 p., 82.

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3 Citations (Scopus)

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2022

Laser desorption tissue imaging with Differential Mobility Spectrometry

Lepomäki, M., Anttalainen, A., Vuorinen, A., Tolonen, T., Kontunen, A., Karjalainen, M., Vehkaoja, A., Roine, A. & Oksala, N., Apr 2022, In: EXPERIMENTAL AND MOLECULAR PATHOLOGY. 125, 10 p., 104759.

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3 Citations (Scopus)

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Population-based randomized trial of screening for clinically significant prostate cancer ProScreen: a pilot study

Rannikko, A., Leht, M., Mirtti, T., Kenttämies, A., Tolonen, T., Rinta-Kiikka, I., Kilpeläinen, T. P., Natunen, K., Lilja, H., Lehtimäki, T., Raitanen, J., Kujala, P., Ronkainen, J., Matikainen, M., Petas, A., Taari, K., Tammela, T. & Auvinen, A., 2022, In: BJU International. 130, 2

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16 Citations (Scopus)

23 Downloads (Pure)

2021

Combined Longitudinal Clinical and Autopsy Phenomic Assessment in Lethal Metastatic Prostate Cancer: Recommendations for Advancing Precision Medicine

Jasu, J., Tolonen, T., Antonarakis, E. S., Beltran, H., Halabi, S., Eisenberger, M. A., Carducci, M. A., Loriot, Y., Van der Eecken, K., Lolkema, M., Ryan, C. J., Taavitsainen, S., Gillessen, S., Högnäs, G., Talvitie, T., Taylor, R. J., Koskenalho, A., Ost, P., Murtola, T. J. & Rinta-Kiikka, I. & 9 others, Tammela, T., Auvinen, A., Kujala, P., Smith, T. J., Kellokumpu-Lehtinen, P. L., Isaacs, W. B., Nykter, M., Kesseli, J. & Bova, G. S., Aug 2021, In: European Urology Open Science. 30, p. 47-62 16 p.

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2 Citations (Scopus)

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Radiological and pathological assessment of response to neoadjuvant CDK4/6 inhibitor and endocrine treatments in a real-life setting: initial results

Moisander, M., Salminen, A., Jukkola, A., Sassi, A., Tervo, M., Mäenpää, N., Tiainen, L., Rinta-Kiikka, I., Tolonen, T. & Arponen, O., 2021, In: Acta Radiologica Open. 10, 8, 9 p.

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2020

Cytokeratin-Supervised Deep Learning for Automatic Recognition of Epithelial Cells in Breast Cancers Stained for ER, PR, and Ki-67

Valkonen, M., Isola, J., Ylinen, O., Muhonen, V., Saxlin, A., Tolonen, T., Nykter, M. & Ruusuvuori, P., 2020, In: IEEE Transactions on Medical Imaging. 39, 2, p. 534-542

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42 Citations (Scopus)

Differential mobility spectrometry imaging for pathological applications

Kontunen, A., Tuominen, J., Karjalainen, M., Anttalainen, O., Tolonen, T., Kumpulainen, P., Lepomäki, M., Vehkaoja, A., Oksala, N. & Roine, A., 1 Dec 2020, In: EXPERIMENTAL AND MOLECULAR PATHOLOGY. 117, 8 p., 104526.

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6 Citations (Scopus)

22 Downloads (Pure)

Expression of the miR-200 family in tumor tissue, plasma and urine of epithelial ovarian cancer patients in comparison to benign counterparts

Savolainen, K., Scaravilli, M., Ilvesmäki, A., Staff, S., Tolonen, T., Mäenpää, J. U., Visakorpi, T. & Auranen, A., 2020, In: BMC Reserach Notes. 13, 311.

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22 Citations (Scopus)

10 Downloads (Pure)

Histopathology and immunohistochemical analysis of 5-fluorouracil and triamcinolone treated keloids in double-blinded randomized controlled trial

Hietanen, K., Järvinen, T., Huhtala, H., Tolonen, T. & Kaartinen, I., 2020, In: WOUND REPAIR AND REGENERATION. 28, 3, p. 385-399

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

2019

Adoption of diagnostic digital pathology in Finland

Näpänkangas, J. & Tolonen, T., 2019, In: Finnish Journal of Ehealthcare And Ewelfare. 11, 4, p. 320-325

Research output: Contribution to journal › Article › Scientific › peer-review

Identification of breast tumors from diathermy smoke by differential ion mobility spectrometry

Lepomäki, M., Kontunen, A., Karjalainen, M., Kiiski, J., Hannus, J., Tolonen, T., Roine, A. & Oksala, N., 2019, In: European Journal of Surgical Oncology. 45, 2, p. 141-146 6 p.

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18 Citations (Scopus)

Treatment of keloid scars with intralesional triamcinolone and 5-fluorouracil injections - a randomized controlled trial

Hietanen, K. E., Järvinen, T. A., Huhtala, H., Tolonen, T. T., Kuokkanen, H. O. & Kaartinen, I. S., 2019, In: Journal of plastic, reconstructive and aesthetic surgery. 72, 1, p. 4-11

Research output: Contribution to journal › Article › Scientific › peer-review

80 Citations (Scopus)

2018

Atorvastatin Versus Placebo for Prostate Cancer Before Radical Prostatectomy--A Randomized, Double-blind, Placebo-controlled Clinical Trial

Murtola, T. J., Syvälä, H., Tolonen, T., Helminen, M., Riikonen, J., Koskimäki, J., Pakarainen, T., Kaipia, A., Isotalo, T., Kujala, P. & Tammela, T. L. J., 2018, In: European Urology. 74, 6, p. 697-701

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55 Citations (Scopus)

Digital image analysis of the tissue surface areas of site-designated and bilaterally pooled prostate biopsies

Koivusalo, L., Kaipia, A., Kujala, P., Isola, J., Tolonen, T. & Heino-Tolonen, T., 2018, In: Histology Histopathology. 33, 4, p. 399-405

Research output: Contribution to journal › Article › Scientific › peer-review

Expression of neuroendocrine differentiation markers in lethal metastatic castration-resistant prostate cancer.

Sainio, M., Visakorpi, T., Tolonen, T., Ilvesaro, J. & Bova, S., 2018, In: Pathology - Research and Practice. 214, 6, p. 848-856

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19 Citations (Scopus)

Extraprostatic extension (pT3a) in prostate biopsy is an under-recognized feature indicating high risk disease

Tolonen, T. T., Riikonen, J., Tammela, T. L. J., Koivusalo, L., Haapasalo, H., Kujala, P. & Kaipia, A., 2018, In: Annals of Diagnostic Pathology. 35, p. 80-84 5 p.

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1 Citation (Scopus)

Feasibility of Prostate PAXgene Fixation for Molecular Research and Diagnostic Surgical Pathology: Comparison of Matched Fresh Frozen, FFPE, and PFPE Tissues

Högnäs, G., Kivinummi, K., Kallio, H. M. L., Hieta, R., Ruusuvuori, P., Koskenalho, A., Kesseli, J., Tammela, T. L. J., Riikonen, J., Ilvesaro, J., Kares, S., Hirvikoski, P. P., Laurila, M., Mirtti, T., Nykter, M., Kujala, P. M., Visakorpi, T., Tolonen, T. & Bova, G. S., 2018, In: American Journal of Surgical Pathology. 42, 1, p. 103-115 13 p.

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13 Citations (Scopus)

Optimized JPEG 2000 Compression for Efficient Storage of Histopathological Whole-Slide Images

Helin, H., Tolonen, T., Ylinen, O., Tolonen, P., Näpänkangas, J. & Isola, J., 2018, In: Journal of Pathology Informatics. 9, 1, p. 20

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26 Citations (Scopus)

2017

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer

Urbanucci, A., Barfeld, S., Kytölä, V., Itkonen, H., Coleman, I. M., Vodák, D., Sjöblom, L., Sheng, X., Tolonen, T., Minner, S., Burdelski, C., Kivinummi, K., Kohvakka, A., Kregel, S., Takhar, M., Alshalalfa, M., Davicioni, E., Erho, N., Lloyd, P. & Karnes, R. & 15 others, Ross, A., Schaeffer, E., Vander Griend, D., Knapp, S., Corey, E., Feng, F., Nelson, P., Saatcioglu, F., Knudsen, K., Tammela, T., Sauter, G., Schlomm, T., Nykter, M., Visakorpi, T. & Mills, I., 2017, In: Cell Reports. 19, 10, p. 2045-2059 15 p.

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90 Citations (Scopus)

47 Downloads (Pure)

2016

Integrated clinical, whole genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer

Bova, G. S., Kallio, H., Annala, M., Kivinummi, K., Högnäs, G., Häyrynen, S., Rantapero, T., Kivinen, V., Isaacs, W., Tolonen, T., Nykter, M., Visakorpi, T. & Bova, S., 2016, In: Cold Spring Harbor Molecular Case Studies. 2, 3, p. a000752

Research output: Contribution to journal › Article › Scientific › peer-review

Microseminoprotein-beta expression in different stages of prostate cancer

Sjöblom, L., Saramäki, O., Annala, M., Leinonen, K., Nättinen, J., Tolonen, T., Wahlfors, T., Nykter, M., Schleutker, J., Tammela, T., Lilja, H., Visakorpi, T. & Bova, S., 2016, In: PLoS ONE. 11, 3, p. e0150241 e0150241.

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28 Citations (Scopus)

2015

CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations

Khanna, A., Rane, J. K., Kivinummi, K. K., Urbanucci, A., Helenius, M. A., Tolonen, T. T., Saramäki, O. R., Latonen, L., Manni, V., Pimanda, J. E., Maitland, N. J., Westermarck, J. & Visakorpi, T., 2015, In: Oncotarget. 6, 23, p. 19661-19670 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

26 Citations (Scopus)

Length of prostate biopsies is not necessarily compromised by pooling multiple cores in one paraffin block: An observational study

Tolonen, T. T., Isola, J., Kaipia, A., Riikonen, J., Koivusalo, L., Huovinen, S., Laurila, M., Porre, S., Tirkkonen, M. & Kujala, P., 2015, In: BMC Clinical Pathology. 15, 4, p. 1-6

Research output: Contribution to journal › Article › Scientific › peer-review

6 Citations (Scopus)

2014

Quantitative analysis of [gamma]-H2AX and p53 nuclear expression levels in ovarian and fallopian tube epithelium from risk-reducing salpingo-oophorectomies in BRCA1 and BRCA2 mutation carriers

Staff, S., Tolonen, T., Laasanen, S.-L., Mecklin, J.-P., Isola, J. & Mäenpää, J., 2014, In: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY. 33, 3, p. 309-16

Research output: Contribution to journal › Article › Scientific › peer-review

8 Citations (Scopus)

2013

Loss of PTEN is associated with aggressive behavior in ERG-positive prostate cancer

Leinonen, K. A., Saramäki, O. R., Furusato, B., Kimura, T., Takahashi, H., Egawa, S., Suzuki, H., Keiger, K., Heino-Tolonen, T., Hahm, S. H., Isaacs, W. B., Tolonen, T. T., Stenman, U.-H., Shin, E., Tammela, T. L., Nykter, M., Bova, G. S., Ho, S. H. & Visakorpi, T., 2013, In: Cancer Epidemioly, Biomarkers & Prevention. 22, 12, p. 2333-2344 12 p.

Research output: Contribution to journal › Article › Scientific › peer-review

114 Citations (Scopus)

2012

ImmunoMembrane: a publicly available web application for digital image analysis of HER2 immunohistochemistry

Tuominen, V. J., Tolonen, T. T. & Isola, J., 2012, In: HISTOPATHOLOGY. 60, 5, p. 758-67

Research output: Contribution to journal › Article › Scientific › peer-review

68 Citations (Scopus)

2011

Histopathological variables and biomarkers enhancer of zeste homologue 2, Ki-67 and minichromosome maintenance protein 7 as prognosticators in primarily endocrine-treated prostate cancer

Tolonen, T. T., Tammela, T. L. J., Kujala, P. M., Tuominen, V. J., Isola, J. J., Visakorpi, T. & Heino-Tolonen, T., 2011, In: British Journal of Urology International. 108, 9, p. 1430-1438 9 p.

Research output: Contribution to journal › Article › Scientific › peer-review

20 Citations (Scopus)

Overall and worst gleason scores are equally good predictors of prostate cancer progression

Tolonen, T. T., Kujala, P. M., Tammela, T. L., Tuominen, V. J., Isola, J. J., Visakorpi, T. & Heino-Tolonen, T., 2011, In: BMC UROLOGY. 11, 21, p. 21 21.

Research output: Contribution to journal › Article › Scientific › peer-review

35 Citations (Scopus)

Routine dual-color immunostaining with a 3-antibody cocktail improves the detection of small cancers in prostate needle biopsies

Tolonen, T. T., Kujala, P. M., Laurila, M., Tirkkonen, M., Ilvesaro, J., Tuominen, V. J., Tammela, T. L. J., Isola, J. & Heino-Tolonen, T., 2011, In: HUMAN PATHOLOGY. 42, 11, p. 1635-1642 8 p.

Research output: Contribution to journal › Article › Scientific › peer-review

10 Citations (Scopus)

2010

Association of SPINK1 expression and TMPRSS2:ERG fusion with prognosis in endocrine-treated prostate cancer

Leinonen, K., Tolonen, T., Bracken, H., Stenman, U., Tammela, T., Saramäki, O., Visakorpi, T. & Heino-Tolonen, T., 2010, In: Clinical Cancer Research. 16, 10, p. 2845-2851

Research output: Contribution to journal › Article › Scientific › peer-review

91 Citations (Scopus)

2008

EZH2, Ki-67 and MCM7 are prognostic markers in prostatectomy treated patients

Laitinen, S., Martikainen, P., Tolonen, T., Isola, J., Tammela, T. & Visakorpi, T., 2008, In: Int J Cancer. 122, 3, p. 595-602

Research output: Contribution to journal › Article › Scientific › peer-review

75 Citations (Scopus)

2007

Bax and Bcl-2 are focally overexpressed in the normal epithelium of cancerous prostates

Tolonen, T., Tommola, S., Jokinen, S., Parviainen, T., Martikainen, P. & Kujala, P., 2007, In: Scand J Urol Nephrol.. 41, 2, p. 85-90

Research output: Contribution to journal › Article › Scientific › peer-review

8 Citations (Scopus)

2005

Dual-specificity phosphatase 1 and serum/glucocorticoid-regulated kinase are downregulated in prostate cancer

Rauhala, H., Porkka, K., Tolonen, T., Martikainen, P., Tammela, T., Visakorpi, T. & Kujala, P., 2005, In: International Journal of Cancer. 117, 5, p. 738-745 8 p.

Research output: Contribution to journal › Article › Scientific › peer-review

68 Citations (Scopus)

Teemu Tolonen

Research output

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