Personal profile

Grants and awards

 

  • 1988 Award International Atherosclerosis Society 
  • 1989 Award for the best advanced studies, Tampere Medical Faculty 
  • 1992 Award from Tampere Medical Association for excellent poster presentation 
  • 1993 Award from Tampere Medical Association for excellent poster presentation 
  • 1995 Award from Tampere Medical Association for excellent poster presentation
  • 2103 University of Tampere, Science Price (First award)             
  • 2014 University of Tampere, Silver badge (for 20 year work career in UTA)
  • 2022 Member of Academia Europeae

 

Dissertation supervision and instruction at other universities

  • Number of supervised PhD theses is (26): Janne Leinonen (1998), Xiaohong Huang (1998), Erkki Ilveskoski, (2001), Mari Luomala (2002), Riikka Rontu (2003), Sami Anttila (2004), Hannu Päivä (2005), Perttu Pöllänen (2005), Yue-Mei Fan (2007), Leena Viiri (2008), Auni Collings (2008), Riikka Mäkelä (2009), Meng Fan (2009), Mari Levula (2009), Jussi Hernesniemi (2010), Ilkka Kivekäs (2011), Sanna Hagman (2011), Jenni Koskela (2014), Kari Hänninen (2014), Emma Raitoharju (2014), Kari-Matti Mäkelä (2015). Ilkka Seppälä (2017), Sanna Jaana Tolonen (2019), Pashupati Mishra (2020), Julia Vistbacka (2022), Jaakko Laaksonen (2022), Most of them being now in a significant administrative (chief doctors) and/or sicientific positions, professors (Hernesniemi J. in Cardiology), associate professors, and three are highly competitive Finnish Academy researchers (Hagmann S, Raitoharju E, Mishra P).

Profile information

T. L’s research interests are focused on cardiovascular disease risk factors, atherosclerotic plaques and vascular cell biology and biomarkers, combination of omics and functional genetics and epigenetics of complex traits and system biology of diseases and related bioinformatics. T.L have authorized > 1247 articles that have been cited > 130.000 times. An average citation per article is 63.39 in Web Science. My Google Scholar h-index is 153 and i10-index 919 (=number of publications with at least 10 citations). My most 6 cited article published in Science, Lancet, Nature, and Nature Genetics has been cited over 3261 times and 10 most cited articles all have > 2122  citations. T.L has actively participated in over 100 Lancet, Nature, Nature Genetics, Science, Cell, JAMA, New England J Med papers over the last 10 years, and as a highlight his work in collaboration and individually has led to the discovery of over 5000 novel genetic variants of complex traits and lead their more-accurate DNA testing. T.L is active member of over 40 international consortia, internationally recognized researcher, and member of Academia Europea. T.L was involved in discovering first time the de novo mutations in families with autistic disorders changing the existing textbook understanding of the inheritance of complex traits from parents. These works were published in Science (Science 2007;316:445-449, >3261 citations) and later by fine mapping with NGS in Nature (Nature. 2014;515:209-15, > 2315 citations) and Cell (Cell. 2020;180(3):568-584.e23.) T.L was also involved in a recent paper in NEJM forming the scientific basis for childhood cardiovascular risk prevention from childhood to adulthood (N Engl J Med. 2022;386(20):1877-1888). The most long-standing interest of T.L. is focused on apolipoprotein E protein (80 publications+4 thesis) with several primary findings. The apoE testing, both analysis from CSF and genotyping are now a part of national/international guidelines for the diagnostic and treatment of dementia. Over the last 10 years, I have been consistently ranked as the number one medical researcher in the TUNI and among the top 3 medical researchers in Finland.
T.L. holds a significant patent (United States Patent No. 60/872,495, 2006) on a novel diagnostic test to predict statin myopathy.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 2 - Zero Hunger
  • SDG 3 - Good Health and Well-being
  • SDG 8 - Decent Work and Economic Growth
  • SDG 10 - Reduced Inequalities

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Collaborations and top research areas from the last five years

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  • Accumulation of Lewy-Related Pathology Starts in Middle Age: The Tampere Sudden Death Study

    Kok, E. H., Paetau, A., Martiskainen, M., Lyytikäinen, L. P., Lehtimäki, T., Karhunen, P. & Myllykangas, L., 2024, (E-pub ahead of print) In: ANNALS OF NEUROLOGY. 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
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  • Clinical and biochemical associations of urinary metabolites: quantitative epidemiological approach on renal-cardiometabolic biomarkers

    Li, T., Ihanus, A., Ohukainen, P., Järvelin, M-R., Kähönen, M., Kettunen, J., Raitakari, O. T., Lehtimäki, T., Mäkinen, V-P., Tynkkynen, T. & Ala-Korpela, M., 2024, In: International Journal of Epidemiology. 53, 1, dyad162.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
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    1 Downloads (Pure)
  • Effect of weight on depression using multiple genetic instruments

    Viinikainen, J., Böckerman, P., Willage, B., Elovainio, M., Kari, J. T., Lehtimäki, T., Pehkonen, J., Pitkänen, N. & Raitakari, O., Feb 2024, In: PLoS ONE. 19, 2 FEBRUARY, 11 p., e0297594.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
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  • Gene expression networks regulated by human personality

    del Val, C., Díaz de la Guardia-Bolívar, E., Zwir, I., Mishra, P. P., Mesa, A., Salas, R., Poblete, G. F., de Erausquin, G., Raitoharju, E., Kähönen, M., Raitakari, O., Keltikangas-Järvinen, L., Lehtimäki, T. & Cloninger, C. R., 2024, (E-pub ahead of print) In: MOLECULAR PSYCHIATRY. 20 p.

    Research output: Contribution to journalReview Articlepeer-review

    Open Access
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    3 Downloads (Pure)
  • Genome-wide characterization of circulating metabolic biomarkers

    Karjalainen, M. K., Karthikeyan, S., Oliver-Williams, C., Sliz, E., Allara, E., Fung, W. T., Surendran, P., Zhang, W., Jousilahti, P., Kristiansson, K., Salomaa, V., Goodwin, M., Hughes, D. A., Boehnke, M., Fernandes Silva, L., Yin, X., Mahajan, A., Neville, M. J., van Zuydam, N. R., de Mutsert, R., & 67 othersLi-Gao, R., Mook-Kanamori, D. O., Demirkan, A., Liu, J., Noordam, R., Trompet, S., Chen, Z., Kartsonaki, C., Li, L., Lin, K., Hagenbeek, F. A., Hottenga, J. J., Pool, R., Ikram, M. A., van Meurs, J., Haller, T., Milaneschi, Y., Kähönen, M., Mishra, P. P., Joshi, P. K., Macdonald-Dunlop, E., Mangino, M., Zierer, J., Acar, I. E., Hoyng, C. B., Lechanteur, Y. T. E., Franke, L., Kurilshikov, A., Zhernakova, A., Beekman, M., van den Akker, E. B., Kolcic, I., Polasek, O., Rudan, I., Gieger, C., Waldenberger, M., Asselbergs, F. W., Hayward, C., Fu, J., den Hollander, A. I., Menni, C., Spector, T. D., Wilson, J. F., Lehtimäki, T., Raitakari, O. T., Penninx, B. W. J. H., Esko, T., Walters, R. G., Jukema, J. W., Sattar, N., Ghanbari, M., Willems van Dijk, K., Karpe, F., McCarthy, M. I., Laakso, M., Järvelin, M. R., Timpson, N. J., Perola, M., Kooner, J. S., Chambers, J. C., van Duijn, C., Slagboom, P. E., Boomsma, D. I., Danesh, J., Ala-Korpela, M., Butterworth, A. S. & Kettunen, J., 2024, In: Nature. 628, 21 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
    File
    2 Downloads (Pure)
  • Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

    McCartney, D. L. (Creator), Min, J. L. (Creator), Richmond, R. C. (Creator), Lu, A. T. (Creator), Sobczyk, M. K. (Creator), Davies, G. (Creator), Broer, L. (Creator), Guo, X. (Creator), Jeong, A. (Creator), Jung, J. (Creator), Kasela, S. (Creator), Katrinli, S. (Creator), Kuo, P. (Creator), Matias-Garcia, P. R. (Creator), Mishra, P. (Creator), Nygaard, M. (Creator), Palviainen, T. (Creator), Patki, A. (Creator), Raffield, L. M. (Creator), Ratliff, S. M. (Creator), Richardson, T. G. (Creator), Robinson, O. (Creator), Soerensen, M. (Creator), Sun, D. (Creator), Tsai, P. (Creator), van der Zee, M. D. (Creator), Walker, R. M. (Creator), Wang, X. (Creator), Wang, Y. (Creator), Xia, R. (Creator), Xu, Z. (Creator), Yao, J. (Creator), Zhao, W. (Creator), Correa, A. (Creator), Boerwinkle, E. (Creator), Dugué, P. (Creator), Durda, P. (Creator), Elliott, H. R. (Creator), Gieger, C. (Creator), de Geus, E. J. C. (Creator), Harris, S. E. (Creator), Hemani, G. (Creator), Imboden, M. (Creator), Kähönen, M. (Creator), Kardia, S. L. R. (Creator), Kresovich, J. K. (Creator), Li, S. (Creator), Lunetta, K. L. (Creator), Mangino, M. (Creator), Mason, D. (Creator), McIntosh, A. M. (Creator), Mengel-From, J. (Creator), Moore, A. Z. (Creator), Murabito, J. M. (Creator), Ollikainen, M. (Creator), Pankow, J. S. (Creator), Pedersen, N. L. (Creator), Peters, A. (Creator), Polidoro, S. (Creator), Porteous, D. J. (Creator), Raitakari, O. (Creator), Rich, S. S. (Creator), Sandler, D. P. (Creator), Sillanpää, E. (Creator), Smith, A. K. (Creator), Southey, M. C. (Creator), Strauch, K. (Creator), Tiwari, H. (Creator), Tanaka, T. (Creator), Tillin, T. (Creator), Uitterlinden, A. G. (Creator), Van Den Berg, D. J. (Creator), van Dongen, J. (Creator), Wilson, J. G. (Creator), Wright, J. (Creator), Yet, I. (Creator), Arnett, D. (Creator), Bandinelli, S. (Creator), Bell, J. T. (Creator), Binder, A. M. (Creator), Boomsma, D. I. (Creator), Chen, W. (Creator), Christensen, K. (Creator), Conneely, K. N. (Creator), Elliott, P. (Creator), Ferrucci, L. (Creator), Fornage, M. (Creator), Hägg, S. (Creator), Hayward, C. (Creator), Irvin, M. (Creator), Kaprio, J. (Creator), Lawlor, D. A. (Creator), Lehtimäki, T. (Creator), Lohoff, F. W. (Creator), Milani, L. (Creator), Milne, R. L. (Creator), Probst-Hensch, N. (Creator), Reiner, A. P. (Creator), Ritz, B. (Creator), Rotter, J. I. (Creator), Smith, J. A. (Creator), Taylor, J. A. (Creator), van Meurs, J. B. J. (Creator), Vineis, P. (Creator), Waldenberger, M. (Creator), Deary, I. J. (Creator), Relton, C. L. (Creator), Horvath, S. (Creator) & Marioni, R. E. (Creator), 30 Jun 2021

    Dataset

  • Childhood exposure to parental smoking and life-course overweight and central obesity

    Jaakkola, J. M. (Creator), Rovio, S. P. (Creator), Pahkala, K. (Creator), Viikari, J. (Creator), Rönnemaa, T. (Creator), Jula, A. (Creator), Niinikoski, H. (Creator), Mykkänen, J. (Creator), Juonala, M. (Creator), Hutri-Kähönen, N. (Creator), Kähönen, M. (Creator), Lehtimäki, T. (Creator) & Raitakari, O. T. (Creator), 22 Feb 2021

    Dataset

  • Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues. Supplementary data

    Raitoharju, E. (Creator), Ollikainen, M. (Creator), Heikkinen, A. (Creator), Laakkonen, E. K. (Creator), Sillanpää, E. (Creator), Raitanen, J. (Creator), Luoto, R. (Creator), März, W. (Creator), E. Kleber, M. (Creator), Waldenberger, M. (Creator), Peters, A. (Creator), Delerue, T. (Creator), Hägg, S. (Creator), Jylhävä, J. (Creator), Kananen, L. (Creator), Kähönen, M. (Creator), Raitakari, O. (Creator), Lehtimäki, T. (Creator), Mishra, P. (Creator), Rajić, S. (Creator), Tamminen, H. (Creator) & Marttila, S. (Creator), 6 Oct 2022

    Dataset