Research output per year
Research output per year
Personal profile
Grants and awards
- 1988 Award International Atherosclerosis Society
- 1989 Award for the best advanced studies, Tampere Medical Faculty
- 1992 Award from Tampere Medical Association for excellent poster presentation
- 1993 Award from Tampere Medical Association for excellent poster presentation
- 1995 Award from Tampere Medical Association for excellent poster presentation
- 2103 University of Tampere, Science Price (First award)
- 2014 University of Tampere, Silver badge (for 20 year work career in UTA)
- 2022 Member of Academia Europeae
Dissertation supervision and instruction at other universities
- Number of supervised PhD theses is (26): Janne Leinonen (1998), Xiaohong Huang (1998), Erkki Ilveskoski, (2001), Mari Luomala (2002), Riikka Rontu (2003), Sami Anttila (2004), Hannu Päivä (2005), Perttu Pöllänen (2005), Yue-Mei Fan (2007), Leena Viiri (2008), Auni Collings (2008), Riikka Mäkelä (2009), Meng Fan (2009), Mari Levula (2009), Jussi Hernesniemi (2010), Ilkka Kivekäs (2011), Sanna Hagman (2011), Jenni Koskela (2014), Kari Hänninen (2014), Emma Raitoharju (2014), Kari-Matti Mäkelä (2015). Ilkka Seppälä (2017), Sanna Jaana Tolonen (2019), Pashupati Mishra (2020), Julia Vistbacka (2022), Jaakko Laaksonen (2022), Most of them being now in a significant administrative (chief doctors) and/or sicientific positions, professors (Hernesniemi J. in Cardiology), associate professors, and three are highly competitive Finnish Academy researchers (Hagmann S, Raitoharju E, Mishra P).
Profile information
T. L’s research interests are focused on cardiovascular disease risk factors, atherosclerotic plaques and vascular cell biology and biomarkers, combination of omics and functional genetics and epigenetics of complex traits and system biology of diseases and related bioinformatics. T.L have authorized > 1247 articles that have been cited > 130.000 times. An average citation per article is 63.39 in Web Science. My Google Scholar h-index is 153 and i10-index 919 (=number of publications with at least 10 citations). My most 6 cited article published in Science, Lancet, Nature, and Nature Genetics has been cited over 3261 times and 10 most cited articles all have > 2122 citations. T.L has actively participated in over 100 Lancet, Nature, Nature Genetics, Science, Cell, JAMA, New England J Med papers over the last 10 years, and as a highlight his work in collaboration and individually has led to the discovery of over 5000 novel genetic variants of complex traits and lead their more-accurate DNA testing. T.L is active member of over 40 international consortia, internationally recognized researcher, and member of Academia Europea. T.L was involved in discovering first time the de novo mutations in families with autistic disorders changing the existing textbook understanding of the inheritance of complex traits from parents. These works were published in Science (Science 2007;316:445-449, >3261 citations) and later by fine mapping with NGS in Nature (Nature. 2014;515:209-15, > 2315 citations) and Cell (Cell. 2020;180(3):568-584.e23.) T.L was also involved in a recent paper in NEJM forming the scientific basis for childhood cardiovascular risk prevention from childhood to adulthood (N Engl J Med. 2022;386(20):1877-1888). The most long-standing interest of T.L. is focused on apolipoprotein E protein (80 publications+4 thesis) with several primary findings. The apoE testing, both analysis from CSF and genotyping are now a part of national/international guidelines for the diagnostic and treatment of dementia. Over the last 10 years, I have been consistently ranked as the number one medical researcher in the TUNI and among the top 3 medical researchers in Finland.
T.L. holds a significant patent (United States Patent No. 60/872,495, 2006) on a novel diagnostic test to predict statin myopathy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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A new blood based epigenetic age predictor for adolescents and young adults
Aanes, H., Bleka, Ø., Dahlberg, P. S., Carm, K. T., Lehtimäki, T., Raitakari, O., Kähönen, M., Hurme, M. & Rolseth, V., Feb 2023, In: Scientific Reports. 13, 10 p., 2303.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile2 Downloads (Pure) -
Childhood Dyslipidemia and Carotid Atherosclerotic Plaque in Adulthood: The Cardiovascular Risk in Young Finns Study
Koskinen, J. S., Kytö, V., Juonala, M., Viikari, J. S. A., Nevalainen, J., Kähönen, M., Lehtimäki, T., Hutri-Kähönen, N., Laitinen, T. P., Tossavainen, P., Jokinen, E., Magnussen, C. G. & Raitakari, O. T., 4 Apr 2023, In: Journal of the American Heart Association. 12, 7, 11 p., e027586.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Downloads (Pure) -
Circulating cell-free DNA in health and disease: the relationship to health behaviours, ageing phenotypes and metabolomics
Kananen, L., Hurme, M., Bürkle, A., Moreno-Villanueva, M., Bernhardt, J., Debacq-Chainiaux, F., Grubeck-Loebenstein, B., Malavolta, M., Basso, A., Piacenza, F., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Jansen, E. H. J. M., Dollé, M. E. T., Salmon, M., Stuetz, W., Weber, D., Grune, T., & 18 others, 2023, In: GeroScience. 45, 1, p. 85–103Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Downloads (Pure) -
Diminishing benefits of urban living for children and adolescents’ growth and development
NCD Risk Factor Collaboration (NCD-RisC), Mishra, A., Zhou, B., Rodriguez-Martinez, A., Bixby, H., Singleton, R. K., Carrillo-Larco, R. M., Sheffer, K. E., Paciorek, C. J., Bennett, J. E., Lhoste, V., Iurilli, M. L. C., Di Cesare, M., Bentham, J., Phelps, N. H., Sophiea, M. K., Stevens, G. A., Danaei, G., Cowan, M. J., Savin, S., & 30 others, 30 Mar 2023, In: Nature. 615, 7954, p. 874-883 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures
Örd, T., Lönnberg, T., Nurminen, V., Ravindran, A., Niskanen, H., Kiema, M., Õunap, K., Maria, M., Moreau, P. R., Mishra, P. P., Palani, S., Virta, J., Liljenbäck, H., Aavik, E., Roivainen, A., Ylä-Herttuala, S., Laakkonen, J. P., Lehtimäki, T. & Kaikkonen, M. U., May 2023, In: AMERICAN JOURNAL OF HUMAN GENETICS. 110, 5, p. 722-740 19 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Downloads (Pure)
Datasets
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CVD risk factors and surrogate markers - Urban-rural differences
Nuotio, J. (Creator), Vähämurto, L. (Creator), Pahkala, K. (Creator), Magnussen, C. G. (Creator), Hutri-Kähönen, N. (Creator), Kähönen, M. (Creator), Laitinen, T. (Creator), Taittonen, L. (Creator), Tossavainen, P. (Creator), Lehtimäki, T. (Creator), Jokinen, E. (Creator), Viikari, J. S. A. (Creator), Raitakari, O. (Creator) & Juonala, M. (Creator), 30 Aug 2019
DOI: 10.25384/sage.c.4649471.v1
Dataset
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Childhood Oral Infections Associate with Adulthood Metabolic Syndrome: A Longitudinal Cohort Study
Pussinen, P. J. (Contributor), Paju, S. (Contributor), Viikari, J. (Contributor), Salminen, A. (Contributor), Taittonen, L. (Contributor), Laitinen, T. (Contributor), Burgner, D. (Contributor), Kähönen, M. (Contributor), Lehtimäki, T. (Contributor), Hutri-Kähönen, N. (Contributor), Raitakari, O. (Contributor) & Juonala, M. (Contributor), 2 Jun 2020
DOI: 10.25384/sage.c.5002757.v1
Dataset
Activities
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Opinnäytetöiden ohjaus, Väitöskirja: Ei tiedossa
Terho Lehtimäki (Examiner)
2019 → 2020Activity: Evaluation, examination and supervision › Supervisor of doctoral candidate
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Opinnäytetöiden ohjaus, Väitöskirja: Evaluation of Cardiovascular Risk by electrocardiographic variables
Terho Lehtimäki (Examiner)
2017 → …Activity: Evaluation, examination and supervision › Supervisor of doctoral candidate
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Opinnäytetöiden ohjaus, Väitöskirja: Ei tiedossa
Terho Lehtimäki (Examiner)
2017 → 2018Activity: Evaluation, examination and supervision › Supervisor of doctoral candidate
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Atorvastatiinin käytön vaikutus eturauhassyöpään - satunnaistettu, lumekontrolloitu kaksoissokkotutkimus
Teemu Murtola (Speaker), Jarno Riikonen (Speaker), Juha Lönnroth (Speaker), Tomi Pakarainen (Speaker), Taina Isotalo (Speaker), Antti Kaipia (Speaker), Paula Kujala (Speaker), Heimo Syvälä (Speaker), Seppo Auriola (Speaker), Emma Raitoharju (Speaker), Terho Lehtimäki (Speaker) & Teuvo Tammela (Speaker)
5 Feb 2015Activity: Talk or presentation › Conference presentation
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Eturauhassyövän havaitseminen elektronista nenää käyttäen
A Roine (Contributor), E Veskimäe (Contributor), A Tuokko (Contributor), P Kumpulainen (Contributor), J Koskimäki (Contributor), T Keinänen (Contributor), M Häkkinen (Contributor), J Vepsäläinen (Contributor), T Paavonen (Contributor), J Lekkala (Contributor), T Lehtimäki (Contributor), T Tammela (Contributor) & N Oksala (Contributor)
21 Mar 2014Activity: Talk or presentation › Conference presentation