µCT based characterization of biomaterial scaffold microstructure under compression

Markus Hannula, Nathaniel Narra, Kaarlo Paakinaho, Anne-Marie Haaparanta, Minna Kellomäki, Jari Hyttinen

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

    1 Citation (Scopus)


    Scaffolds are often designed with progressive degradation to make way for cell proliferation of seeded cells for native tissue. The viability of the scaffold has been shown to depend on, among other things, the microstructure. Common parameters, that are used to describe microstructure, are porosity, material thickness, pore size and surface area. These properties quantify the suitability of the scaffold as a substrate for cell adhesion, fluid exchange and nutrient transfer. Bone and cartilage scaffolds are often placed or operated under loads (predominantly compression). This can alter the structural parameters depending on the stiffness of the scaffold and applied deformation. It is important to know, how scaffolds’ parameters change under deformation. In this study, two scaffolds (PLCL-TCP and collagen-PLA) intended for use in bone and cartilage applications, were studied through micro computed tomography based imaging and in situ mechanical testing. The scaffolds were subjected to uniaxial compressive deformation up to 50% of the original size. The corresponding changes in the individual scaffold bulk characteristics were analyzed. Our results show an expected decrease in porosity with increasing deformation (with PLCL-TCP scaffold 52% deformation resulted in 56% decrease in porosity). Especially in the sandwich constructs of collagen-PLA, but also in PLCL-TCP composites, it was evident that different materials are affected differently which may be of significance in applications with mechanical loading. Our results are a step towards understanding the changes in the structure of these scaffolds under loading.

    Original languageEnglish
    Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering 2018
    Number of pages5
    ISBN (Electronic)978-981-10-9023-3
    Publication statusPublished - 2019
    Publication typeA4 Article in conference proceedings
    EventWorld Congress on Medical Physics and Biomedical Engineering -
    Duration: 1 Jan 1900 → …

    Publication series

    NameIFMBE Proceedings
    ISSN (Print)1680-0737


    ConferenceWorld Congress on Medical Physics and Biomedical Engineering
    Period1/01/00 → …


    • Biomaterials
    • Compression
    • In situ imaging
    • Porosity
    • X-ray microtomography

    Publication forum classification

    • Publication forum level 1

    ASJC Scopus subject areas

    • Bioengineering
    • Biomedical Engineering


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