3D-Printed Whole Prostate Models with Tumor Hotspots Using Dual-Extruder Printer

Kaisa Liimatainen, Leena Latonen, Kimmo Kartasalo, Pekka Ruusuvuori

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

    Abstract

    3D printing has emerged as a popular technology in various biomedical applications. Physical models of anatomical structures concretize the digital representations and can be used for teaching and analysis. In this study we combine 3D histology with 3D printing, creating realistic physical models of tissues with hotspots of interest. As an example we use mouse prostates containing tumors. Surface meshes are created from binary masks of HE-stained serial sections of mouse prostates and manually annotated tumor areas. Sections are interpolated to expand sparse image stacks for smoother results. Fiji, Meshlab and Tinkercad are used for mesh creation and processing. Objects are printed with Prusa-based dual-extruder printer enabling different colors for tumors and the surrounding prostate tissue. Our 3D-printed mouse prostates appear realistic and tumors located at the edges of the organ are clearly visible. When transparent filament is used, the tumor hotspots are visible even when they are inside the prostate.
    Original languageEnglish
    Title of host publication2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
    PublisherIEEE
    Pages2867-2871
    Number of pages5
    ISBN (Print)978-1-5386-1312-2
    DOIs
    Publication statusPublished - 2019
    Publication typeA4 Article in conference proceedings
    EventANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY -
    Duration: 1 Jan 2019 → …

    Publication series

    NameAnnual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
    ISSN (Print)1557-170X

    Conference

    ConferenceANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY
    Period1/01/19 → …

    Keywords

    • Biological system modeling
    • Interpolation
    • Models of organ physiology
    • Organ modeling
    • Solid modeling
    • Three-dimensional displays
    • Three-dimensional printing
    • Tumors

    Publication forum classification

    • Publication forum level 1

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