96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

Tiina Heikkila; Leena Peltonen; Saila Taskinen; Timo Laaksonen; Jouni Hirvonen

96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

Tiina Heikkila
, Leena Peltonen
, Saila Taskinen
, Timo Laaksonen
, Jouni Hirvonen

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

Abstract

Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing.

Original language	English
Pages (from-to)	471-476
Number of pages	6
Journal	Letters in Drug Design and Discovery
Volume	5
Publication status	Published - 2008
Externally published	Yes
Publication type	A1 Journal article-refereed

Keywords

Solubility
Surface tension
Ibuprofen
Indomethacin
High throughput screening (HTS)
96-well plate
HIGH-THROUGHPUT
AQUEOUS SOLUBILITY
DISCOVERY
PERMEABILITY
NEPHELOMETRY
EQUILIBRIUM
VALIDATION
ASSAY

Cite this

@article{524577c432c84cb984da7e828a106ea3,

title = "96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility",

abstract = "Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing.",

keywords = "Solubility, Surface tension, Ibuprofen, Indomethacin, High throughput screening (HTS), 96-well plate, HIGH-THROUGHPUT, AQUEOUS SOLUBILITY, DISCOVERY, PERMEABILITY, NEPHELOMETRY, EQUILIBRIUM, VALIDATION, ASSAY",

author = "Tiina Heikkila and Leena Peltonen and Saila Taskinen and Timo Laaksonen and Jouni Hirvonen",

year = "2008",

language = "English",

volume = "5",

pages = "471--476",

journal = "Letters in Drug Design and Discovery",

issn = "1570-1808",

publisher = "KeAi Communications Co.",

}

TY - JOUR

T1 - 96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

AU - Heikkila, Tiina

AU - Peltonen, Leena

AU - Taskinen, Saila

AU - Laaksonen, Timo

AU - Hirvonen, Jouni

PY - 2008

Y1 - 2008

N2 - Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing.

AB - Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing.

KW - Solubility

KW - Surface tension

KW - Ibuprofen

KW - Indomethacin

KW - High throughput screening (HTS)

KW - 96-well plate

KW - HIGH-THROUGHPUT

KW - AQUEOUS SOLUBILITY

KW - DISCOVERY

KW - PERMEABILITY

KW - NEPHELOMETRY

KW - EQUILIBRIUM

KW - VALIDATION

KW - ASSAY

M3 - Article

SN - 1570-1808

VL - 5

SP - 471

EP - 476

JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

ER -

96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

Abstract

Keywords

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Cite this