A Higher Mean Heart Radiation Dose Induces Higher Frequency of Multiple Cardiac Changes

Suvi Sirkku Tuohinen; Hanna Aula; Tanja Skyttä; Heini Huhtala; Konsta Keski-Pukkila; Kjell Nikus; Vesa Virtanen; Pirkko Liisa Kellokumpu-Lehtinen; Pekka Raatikainen

doi:10.21873/anticanres.15730

A Higher Mean Heart Radiation Dose Induces Higher Frequency of Multiple Cardiac Changes

Suvi Sirkku Tuohinen, Hanna Aula, Tanja Skyttä, Heini Huhtala, Konsta Keski-Pukkila, Kjell Nikus, Vesa Virtanen, Pirkko Liisa Kellokumpu-Lehtinen, Pekka Raatikainen

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Abstract

BACKGROUND/AIM: Radiotherapy (RT) induces late changes in all cardiac structures. Most studies of early changes focus on individual parameters. PATIENTS AND METHODS: Data from eighty early-stage breast cancer patients at baseline, post-RT and three-year follow-up visit were assessed prospectively. Changes in ten cardiac parameters were collected including electrocardiogram (ECG), echocardiography, and biomarkers. A percentage of abnormal changes was calculated. RESULTS: The mean heart radiation dose (Dmean) was independently associated with the increased incidence of changes post-RT (β=0.403, p<0.001) and at the three-year follow-up (β=0.353, p=0.001). Each 1-Gray increase in Dmean increased the cardiac changes by 3.7% (95%CI=1.9-5.6%) after RT and 3.1% (95%CI=1.3, 4.9%) at the three-year follow-up. CONCLUSION: A higher cardiac radiation dose was independently associated with a higher incidence of changes in cardiac parameters. Multiparameter changes imply that the early phase after RT is already characterized by several overlapping cardiac changes.

Original language	English
Pages (from-to)	2519-2529
Number of pages	11
Journal	Anticancer research
Volume	42
Issue number	5
DOIs	https://doi.org/10.21873/anticanres.15730
Publication status	Published - May 2022
Publication type	A1 Journal article-refereed

Keywords

Breast cancer
cardiac biomarkers
ECG
echocardiography
radiotherapy

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.15730Licence: CC BY-NC-ND

2519.fullFinal published version, 3.1 MBLicence: CC BY-NC-ND

https://urn.fi/URN:NBN:fi:tuni-202205164913Licence: CC BY-NC-ND

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title = "A Higher Mean Heart Radiation Dose Induces Higher Frequency of Multiple Cardiac Changes",

abstract = "BACKGROUND/AIM: Radiotherapy (RT) induces late changes in all cardiac structures. Most studies of early changes focus on individual parameters. PATIENTS AND METHODS: Data from eighty early-stage breast cancer patients at baseline, post-RT and three-year follow-up visit were assessed prospectively. Changes in ten cardiac parameters were collected including electrocardiogram (ECG), echocardiography, and biomarkers. A percentage of abnormal changes was calculated. RESULTS: The mean heart radiation dose (Dmean) was independently associated with the increased incidence of changes post-RT (β=0.403, p<0.001) and at the three-year follow-up (β=0.353, p=0.001). Each 1-Gray increase in Dmean increased the cardiac changes by 3.7% (95%CI=1.9-5.6%) after RT and 3.1% (95%CI=1.3, 4.9%) at the three-year follow-up. CONCLUSION: A higher cardiac radiation dose was independently associated with a higher incidence of changes in cardiac parameters. Multiparameter changes imply that the early phase after RT is already characterized by several overlapping cardiac changes.",

keywords = "Breast cancer, cardiac biomarkers, ECG, echocardiography, radiotherapy",

author = "Tuohinen, {Suvi Sirkku} and Hanna Aula and Tanja Skytt{\"a} and Heini Huhtala and Konsta Keski-Pukkila and Kjell Nikus and Vesa Virtanen and Kellokumpu-Lehtinen, {Pirkko Liisa} and Pekka Raatikainen",

year = "2022",

month = may,

doi = "10.21873/anticanres.15730",

language = "English",

volume = "42",

pages = "2519--2529",

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TY - JOUR

T1 - A Higher Mean Heart Radiation Dose Induces Higher Frequency of Multiple Cardiac Changes

AU - Tuohinen, Suvi Sirkku

AU - Aula, Hanna

AU - Skyttä, Tanja

AU - Huhtala, Heini

AU - Keski-Pukkila, Konsta

AU - Nikus, Kjell

AU - Virtanen, Vesa

AU - Kellokumpu-Lehtinen, Pirkko Liisa

AU - Raatikainen, Pekka

PY - 2022/5

Y1 - 2022/5

N2 - BACKGROUND/AIM: Radiotherapy (RT) induces late changes in all cardiac structures. Most studies of early changes focus on individual parameters. PATIENTS AND METHODS: Data from eighty early-stage breast cancer patients at baseline, post-RT and three-year follow-up visit were assessed prospectively. Changes in ten cardiac parameters were collected including electrocardiogram (ECG), echocardiography, and biomarkers. A percentage of abnormal changes was calculated. RESULTS: The mean heart radiation dose (Dmean) was independently associated with the increased incidence of changes post-RT (β=0.403, p<0.001) and at the three-year follow-up (β=0.353, p=0.001). Each 1-Gray increase in Dmean increased the cardiac changes by 3.7% (95%CI=1.9-5.6%) after RT and 3.1% (95%CI=1.3, 4.9%) at the three-year follow-up. CONCLUSION: A higher cardiac radiation dose was independently associated with a higher incidence of changes in cardiac parameters. Multiparameter changes imply that the early phase after RT is already characterized by several overlapping cardiac changes.

AB - BACKGROUND/AIM: Radiotherapy (RT) induces late changes in all cardiac structures. Most studies of early changes focus on individual parameters. PATIENTS AND METHODS: Data from eighty early-stage breast cancer patients at baseline, post-RT and three-year follow-up visit were assessed prospectively. Changes in ten cardiac parameters were collected including electrocardiogram (ECG), echocardiography, and biomarkers. A percentage of abnormal changes was calculated. RESULTS: The mean heart radiation dose (Dmean) was independently associated with the increased incidence of changes post-RT (β=0.403, p<0.001) and at the three-year follow-up (β=0.353, p=0.001). Each 1-Gray increase in Dmean increased the cardiac changes by 3.7% (95%CI=1.9-5.6%) after RT and 3.1% (95%CI=1.3, 4.9%) at the three-year follow-up. CONCLUSION: A higher cardiac radiation dose was independently associated with a higher incidence of changes in cardiac parameters. Multiparameter changes imply that the early phase after RT is already characterized by several overlapping cardiac changes.

KW - Breast cancer

KW - cardiac biomarkers

KW - ECG

KW - echocardiography

KW - radiotherapy

U2 - 10.21873/anticanres.15730

DO - 10.21873/anticanres.15730

M3 - Article

C2 - 35489742

AN - SCOPUS:85129143665

SN - 1791-7530

VL - 42

SP - 2519

EP - 2529

JO - Anticancer research

JF - Anticancer research

IS - 5

ER -

A Higher Mean Heart Radiation Dose Induces Higher Frequency of Multiple Cardiac Changes

Abstract

Keywords

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ASJC Scopus subject areas

UN SDGs

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