A new algorithm to improve assessment of cortical bone geometry in pQCT

Tomas Cervinka, Harri Sievänen, Deena Lala, Angela M. Cheung, Lora Giangregorio, Jari Hyttinen

    Research output: Contribution to journalArticleScientificpeer-review

    4 Citations (Scopus)


    High-resolution peripheral quantitative computed tomography (HR-pQCT) is now considered the leading imaging modality in bone research. However, access to HR-pQCT is limited and image acquisition is mainly constrained only for the distal third of appendicular bones. Hence, the conventional pQCT is still commonly used despite inaccurate threshold-based segmentation of cortical bone that can compromise the assessment of whole bone strength. Therefore, this study addressed whether the use of an advanced image processing algorithm, called OBS, can enhance the cortical bone analysis in pQCT images and provide similar information to HR-pQCT when the same volumes of interest are analyzed. Using pQCT images of European Forearm Phantom (EFP), and pQCT and HR-pQCT images of the distal tibia from 15 cadavers, we compared the results from the OBS algorithm with those obtained from common pQCT analyses, HR-pQCT manual analysis (considered as a gold standard) and common HR-pQCT analysis dual threshold technique.We found that the use of OBS segmentation method for pQCT image analysis of EFP data did not result in any improvement but reached similar performance in cortical bone delineation as did HR-pQCT image analyses. The assessments of cortical cross-sectional bone area and thickness by OBS algorithm were overestimated by less than 4% while area moments of inertia were overestimated by ~5-10%, depending on reference HR-pQCT analysis method. In conclusion, this study showed that the OBS algorithm performed reasonably well and it offers a promising practical tool to enhance the assessment of cortical bone geometry in pQCT.

    Original languageEnglish
    Pages (from-to)721-730
    Number of pages10
    Publication statusPublished - 1 Dec 2015
    Publication typeA1 Journal article-refereed


    • Bone strength
    • Cortical bone
    • HR-pQCT
    • PQCT
    • Segmentation

    Publication forum classification

    • Publication forum level 2

    ASJC Scopus subject areas

    • Physiology
    • Endocrinology, Diabetes and Metabolism
    • Histology


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