A potential nonthrombogenic small-diameter vascular scaffold with polyurethane/poly(ethylene glycol) hybrid materials by electrospinning technique

Heyun Wang, Yakai Feng, Haiyang Zhao, Zichen Fang, Musammir Khan, Jintang Guo

    Research output: Contribution to journalArticleScientificpeer-review

    18 Citations (Scopus)

    Abstract

    A small-diameter vascular graft (inner diameter 4 mm) was fabricated from polyurethane (PU) and poly(ethylene glycol) (PEG) solutions by electrospinning technology. The fiber diameter decreased from 1023±185 nm to 394±106 nm with increasing weight ratio of PEG in electrospinning solutions. The PU/PEG scaffolds showed randomly nanofibrous morphology and well-interconnected porous structure. The hydrophilicity of these scaffolds was improved significantly with increasing weight ratio of PEG. The mechanical properties of electrospun PU/PEG scaffolds were obviously different from that of pure PU scaffold, which was caused by plasticizing or hardening effect imparted by PEG composition. Under hydrated state, the PU/PEG scaffolds demonstrated low mechanical performance due to the hydrophilic property of materials. Compared with dry PU/PEG scaffolds with the same weight ratio of PEG, the tensile strength and elastic modulus of hydrated PU/PEG scaffolds decreased significantly, while the elongation at break increased. The results demonstrated that the electrospun PU/PEG hybrid tubular scaffolds are potential candidates for artificial blood vessels.

    Original languageEnglish
    Pages (from-to)1578-1582
    Number of pages5
    JournalJournal Nanoscience and Nanotechnology
    Volume13
    Issue number2
    DOIs
    Publication statusPublished - Feb 2013
    Publication typeA1 Journal article-refereed

    Keywords

    • Electrospinning
    • Nanofiber
    • Poly(ethylene glycol)
    • Polyurethane
    • Vascular scaffold

    ASJC Scopus subject areas

    • Condensed Matter Physics
    • Chemistry(all)
    • Materials Science(all)
    • Bioengineering
    • Biomedical Engineering

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