A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries: Different practices of assessment and management

Nadine G. Andersson, Mathias Rathe, Ingolf Mølle, Kirsten Brunswig Jarvis, Marianne Hoffmann, Anu Huurre, Joel Joelsson, Birgitte Klug Albertsen, Olli Lohi, Satu Långström, Ulrik Overgaard, Sonata Saulyte Trakymiene, Kaisa Vepsäläinen, Hartmut Vogt, Susanna Ranta

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    Abstract

    Patients undergoing treatment for acute lymphoblastic leukaemia (ALL) are at risk of coagulopathy, especially thromboembolism. We conducted a survey on practices in the assessment and management of coagulopathy during the new ALLTogether protocol in 29 (17 paediatric, 12 adult) Nordic and Baltic cancer centres. While 92% of adult centres used thromboprophylaxis with low-molecular-weight heparin, no paediatric centre did. Almost all providers performed baseline coagulation studies, but only 59% continued the assessment. Fibrinogen replacement was conducted in 59%, and antithrombin replacement in 28% of the centres. The survey highlights the need for guidelines in the management of coagulopathy during ALL therapy.

    Original languageEnglish
    Number of pages5
    JournalBritish Journal of Haematology
    Volume199
    Issue number1
    DOIs
    Publication statusPublished - 2022
    Publication typeA1 Journal article-refereed

    Keywords

    • ALL
    • antithrombin
    • childhood leukaemia
    • paediatric haemostasis
    • paediatric thrombosis
    • thrombosis

    Publication forum classification

    • Publication forum level 2

    ASJC Scopus subject areas

    • Hematology

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