Accumulation of Lewy-Related Pathology Starts in Middle Age: The Tampere Sudden Death Study

Eloise H. Kok; Anders Paetau; Mika Martiskainen; Leo Pekka Lyytikäinen; Terho Lehtimäki; Pekka Karhunen; Liisa Myllykangas

doi:10.1002/ana.26912

Accumulation of Lewy-Related Pathology Starts in Middle Age: The Tampere Sudden Death Study

Eloise H. Kok, Anders Paetau, Mika Martiskainen, Leo Pekka Lyytikäinen, Terho Lehtimäki, Pekka Karhunen, Liisa Myllykangas

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

11 Downloads (Pure)

Abstract

When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha-synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy-related pathology (LRP). The youngest LRP case was aged 54 years, and the frequency of LRP in individuals aged ≥50 years was 9%. This forensic autopsy study indicates LRP starts already in middle age and is more common than expected in the ≥50 years-of-age non-hospitalized population. ANN NEUROL 2024.

Original language	English
Pages (from-to)	843-848
Number of pages	6
Journal	ANNALS OF NEUROLOGY
Volume	95
Issue number	5
Early online date	2024
DOIs	https://doi.org/10.1002/ana.26912
Publication status	Published - May 2024
Publication type	A1 Journal article-refereed

Publication forum classification

Publication forum level 3

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1002/ana.26912Licence: CC BY

Annals of Neurology - 2024 - Kok - Accumulation of Lewy‐Related Pathology Starts in Middle Age The Tampere Sudden DeathFinal published version, 13 MBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202404183744Licence: CC BY

Cite this

@article{965ad45cebee45cc86113d91e5880a8c,

title = "Accumulation of Lewy-Related Pathology Starts in Middle Age: The Tampere Sudden Death Study",

abstract = "When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha-synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy-related pathology (LRP). The youngest LRP case was aged 54 years, and the frequency of LRP in individuals aged ≥50 years was 9%. This forensic autopsy study indicates LRP starts already in middle age and is more common than expected in the ≥50 years-of-age non-hospitalized population. ANN NEUROL 2024.",

author = "Kok, {Eloise H.} and Anders Paetau and Mika Martiskainen and Lyytik{\"a}inen, {Leo Pekka} and Terho Lehtim{\"a}ki and Pekka Karhunen and Liisa Myllykangas",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.",

year = "2024",

month = may,

doi = "10.1002/ana.26912",

language = "English",

volume = "95",

pages = "843--848",

journal = "ANNALS OF NEUROLOGY",

issn = "0364-5134",

publisher = "Wiley",

number = "5",

}

TY - JOUR

T1 - Accumulation of Lewy-Related Pathology Starts in Middle Age

T2 - The Tampere Sudden Death Study

AU - Kok, Eloise H.

AU - Paetau, Anders

AU - Martiskainen, Mika

AU - Lyytikäinen, Leo Pekka

AU - Lehtimäki, Terho

AU - Karhunen, Pekka

AU - Myllykangas, Liisa

PY - 2024/5

Y1 - 2024/5

N2 - When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha-synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy-related pathology (LRP). The youngest LRP case was aged 54 years, and the frequency of LRP in individuals aged ≥50 years was 9%. This forensic autopsy study indicates LRP starts already in middle age and is more common than expected in the ≥50 years-of-age non-hospitalized population. ANN NEUROL 2024.

AB - When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha-synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy-related pathology (LRP). The youngest LRP case was aged 54 years, and the frequency of LRP in individuals aged ≥50 years was 9%. This forensic autopsy study indicates LRP starts already in middle age and is more common than expected in the ≥50 years-of-age non-hospitalized population. ANN NEUROL 2024.

U2 - 10.1002/ana.26912

DO - 10.1002/ana.26912

M3 - Article

C2 - 38501694

AN - SCOPUS:85188649515

SN - 0364-5134

VL - 95

SP - 843

EP - 848

JO - ANNALS OF NEUROLOGY

JF - ANNALS OF NEUROLOGY

IS - 5

ER -

Accumulation of Lewy-Related Pathology Starts in Middle Age: The Tampere Sudden Death Study

Abstract

Publication forum classification

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this