Adverse COVID-19 vaccination effects in Finnish patients with Ménière's disease: A cross-sectional study

Eldre Beukes, Vinaya Manchaiah, Nora Pyykkö, Ilmari Pyykkö

    Research output: Contribution to journalArticleScientificpeer-review

    10 Downloads (Pure)


    Background: The association between reporting adverse coronavirus disease 2019 (COVID-19) vaccination effects and those with a history of audiovestibular difficulties is unknown. The aim of this research is therefore to investigate adverse vaccination effects in adults with a history of Ménière's disease. Specifically, the incidence of adverse effects, the factors associated with those reporting adverse effects and the relationship between the reporting of audiovestibular and other adverse effects. Methods: A mixed-methods exploratory cross-sectional survey study design was used. Data were collected from 333 members of the Finnish Ménière Association. The survey was designed to obtain demographic information that may be associated with having adverse effects or not, vaccination-specific information and adverse vaccination effects. Both health and audiovestibular adverse events were identified. Data analysis included comparing those reporting and not reporting adverse vaccination effects. Results: The mean age was 63 years with 81% being female. Of the 327 respondents who had one of the COVID-19 vaccinations (Comirnatry/ Pfizer, Astra Zeneca, or Moderna), 203 (62%) reported no adverse effects. The type of or number of vaccinations were not related to the reporting of adverse effects. The most frequently reported adverse effects were injection site tenderness (38%), arm pain (21%), fever (15%) and headaches (15%). Post-vaccination tinnitus and vertigo (both 7%) were the most frequently reported audiovestibular-related symptoms, followed by aural fullness (6%) and hearing loss (4%). Those reporting previous pre-vaccination vertigo were more likely to have post-vaccination vertigo. The presence of post-vaccination tinnitus, hearing loss, and aural fullness, predicted the presence of post-vaccination vertigo. Conclusions: A small proportion of patients with a history of Ménière's disease may experience adverse post-vaccination effects. Further research is required to explore whether adverse post-vaccination audiovestibular effects are more prevalent in those with a history of otological disorders compared with the general population.

    Original languageEnglish
    Article number893
    Publication statusPublished - 2022
    Publication typeA1 Journal article-refereed


    • Audiovestibular
    • COVID-19
    • COVID-19 vaccination
    • Hearing loss
    • Ménière's disease
    • Tinnitus
    • Vertigo

    Publication forum classification

    • Publication forum level 1

    ASJC Scopus subject areas

    • General Biochemistry,Genetics and Molecular Biology
    • General Immunology and Microbiology
    • Pharmacology, Toxicology and Pharmaceutics(all)


    Dive into the research topics of 'Adverse COVID-19 vaccination effects in Finnish patients with Ménière's disease: A cross-sectional study'. Together they form a unique fingerprint.

    Cite this