Age at asthma diagnosis is related to prevalence and characteristics of asthma symptoms

Hanna Hisinger-Mölkänen, Jasmin Honkamäki, Hannu Kankaanranta, Leena Tuomisto, Helena Backman, Heidi Andersen, Ari Lindqvist, Lauri Lehtimäki, Anssi Sovijärvi, Eva Rönmark, Paula Pallasaho, Pinja Ilmarinen, Päivi Piirilä

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    2 Citations (Scopus)
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    Abstract

    BACKGROUND: Although asthma may begin at any age, knowledge about relationship between asthma age of onset and the prevalence and character of different symptoms is scarce.

    OBJECTIVES: The aim of this study was to investigate if adult-diagnosed asthma is associated with more symptoms and different symptom profiles than child-diagnosed asthma.

    METHODS: A FinEsS postal survey was conducted in a random sample of 16 000 20-69-year-old Finnish adults in 2016. Those reporting physician-diagnosed asthma and age at asthma diagnosis were included. Age 18 years was chosen to delineate child- and adult-diagnosed asthma.

    RESULTS: Of responders (N = 8199, 51.5%), 842 (10.3%) reported asthma diagnosis. Adult-diagnosed asthma was reported by 499 (59.3%) and child-diagnosed by 343 (40.7%). Of responders with adult-diagnosed and child-diagnosed asthma, 81.8% versus 60.6% used asthma medication (p < 0.001), respectively. Current asthma was also more prevalent in adult-diagnosed asthma (89.2% versus 72.0%, p < 0.001). Risk factors of attacks of breathlessness during the last 12 months were adult-diagnosis (OR = 2.41, 95% CI 1.64-3.54, p < 0.001), female gender (OR = 1.49, 1.07-2.08, p = 0.018), family history of asthma (OR = 1.48, 1.07-2.04, p = 0.018) and allergic rhinitis (OR = 1.49, 1.07-2.09, p = 0.019). All the analysed asthma symptoms, except dyspnea in exercise, were more prevalent in adult-diagnosed asthma in age- and gender-adjusted analyses (p = 0.032-<0.001) which was also more often associated with 5 or more asthma symptoms (p < 0.001) and less often with non-symptomatic appearance (p < 0.001) than child-diagnosed asthma.

    CONCLUSION: Responders with adult-diagnosed asthma had more often current asthma and a higher and multiform asthma symptom burden, although they used asthma medication more often compared to responders with child-diagnosed asthma.

    Original languageEnglish
    Article number100675
    Number of pages15
    JournalWorld Allergy Organization Journal
    Volume15
    Issue number9
    DOIs
    Publication statusPublished - Sept 2022
    Publication typeA1 Journal article-refereed

    Keywords

    • Age of onset
    • Asthma
    • Late-onset
    • Population study
    • Symptom

    Publication forum classification

    • Publication forum level 1

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Pulmonary and Respiratory Medicine

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