Ageing and cognition in men with fragile X syndrome

Oili Sauna-aho, Nina Bjelogrlic-Laakso, Päivi Rautava, Maria Arvio

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Abstract

Background: Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. The aim of our longitudinal study was to describe ageing-related cognitive changes in men with FXS. Method: A neuropsychologist determined the raw scores (RSs) of 19 men with FXS twice with the Leiter International Performance Scale at an average interval of 22 years. The ages of the participants at baseline ranged from 16 to 50 (mean 27) years. Results: At follow-up, the RSs improved in two men, remained the same in two men and declined in 15 men. Overall, the RS of the study group deteriorated by an average 4 points in RSs (p <.001). Conclusion: Cognitive ageing in men with FXS started earlier than that in men in the general population; in many cases, cognitive ageing in men with FXS began before middle age, usually without any medical or other underlying cause.

Original languageEnglish
Pages (from-to)1113-1118
Number of pages6
JournalJOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
Volume33
Issue number5
DOIs
Publication statusPublished - 2020
Publication typeA1 Journal article-refereed

Keywords

  • ageing
  • cognitive development
  • fragile X syndrome
  • intellectual disability

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Education
  • Developmental and Educational Psychology

Fingerprint

Dive into the research topics of 'Ageing and cognition in men with fragile X syndrome'. Together they form a unique fingerprint.

Cite this