An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiatio

Jonna Saarimäki-Wire; Diego Balboa; Mark A Russell; Juha Saarikettu; Matias Kinnunen; Salla Keskitalo; Amrinder Malhi; Cristina Valensisi; Andrus Colin; Solja Eurola; Heli Grym; Jarkko Ustinov; Kimmo Wartiovaara; David R Hawkins; Olli Silvennoinen; Markku Varjosalo; Noel G Morgan; Timo Otonkoski

doi:10.1016/j.celrep.2017.03.055

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiatio

Jonna Saarimäki-Wire, Diego Balboa, Mark A Russell, Juha Saarikettu, Matias Kinnunen, Salla Keskitalo, Amrinder Malhi, Cristina Valensisi, Andrus Colin, Solja Eurola, Heli Grym, Jarkko Ustinov, Kimmo Wartiovaara, David R Hawkins, Olli Silvennoinen, Markku Varjosalo, Noel G Morgan, Timo Otonkoski

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41 Citations (Scopus)

Original language	English
Pages (from-to)	281-294
Journal	Cell Reports
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2017.03.055
Publication status	Published - 2017
Publication type	A1 Journal article-refereed

Keywords

CRISPR
NEUROG3
STAT3
beta cell
endocrine cells
genome editing
iPSC
monogenic diabetes
pancreatic differentiation
stem cells

Publication forum classification

Publication forum level 1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.celrep.2017.03.055

Cite this

Saarimäki-Wire, J., Balboa, D., Russell, M. A., Saarikettu, J., Kinnunen, M., Keskitalo, S., Malhi, A., Valensisi, C., Colin, A., Eurola, S., Grym, H., Ustinov, J., Wartiovaara, K., Hawkins, D. R., Silvennoinen, O., Varjosalo, M., Morgan, N. G., & Otonkoski, T. (2017). An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiatio. Cell Reports, 19(2), 281-294. https://doi.org/10.1016/j.celrep.2017.03.055

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title = "An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiatio",

keywords = "CRISPR, NEUROG3, STAT3, beta cell, endocrine cells, genome editing, iPSC, monogenic diabetes, pancreatic differentiation, stem cells, CRISPR, NEUROG3, STAT3, beta cell, endocrine cells, genome editing, iPSC, monogenic diabetes, pancreatic differentiation, stem cells",

author = "Jonna Saarim{\"a}ki-Wire and Diego Balboa and Russell, {Mark A} and Juha Saarikettu and Matias Kinnunen and Salla Keskitalo and Amrinder Malhi and Cristina Valensisi and Andrus Colin and Solja Eurola and Heli Grym and Jarkko Ustinov and Kimmo Wartiovaara and Hawkins, {David R} and Olli Silvennoinen and Markku Varjosalo and Morgan, {Noel G} and Timo Otonkoski",

year = "2017",

doi = "10.1016/j.celrep.2017.03.055",

language = "English",

volume = "19",

pages = "281--294",

journal = "Cell Reports",

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number = "2",

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Saarimäki-Wire, J, Balboa, D, Russell, MA, Saarikettu, J, Kinnunen, M, Keskitalo, S, Malhi, A, Valensisi, C, Colin, A, Eurola, S, Grym, H, Ustinov, J, Wartiovaara, K, Hawkins, DR, Silvennoinen, O, Varjosalo, M, Morgan, NG & Otonkoski, T 2017, 'An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiatio', Cell Reports, vol. 19, no. 2, pp. 281-294. https://doi.org/10.1016/j.celrep.2017.03.055

TY - JOUR

T1 - An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiatio

AU - Saarimäki-Wire, Jonna

AU - Balboa, Diego

AU - Russell, Mark A

AU - Saarikettu, Juha

AU - Kinnunen, Matias

AU - Keskitalo, Salla

AU - Malhi, Amrinder

AU - Valensisi, Cristina

AU - Colin, Andrus

AU - Eurola, Solja

AU - Grym, Heli

AU - Ustinov, Jarkko

AU - Wartiovaara, Kimmo

AU - Hawkins, David R

AU - Silvennoinen, Olli

AU - Varjosalo, Markku

AU - Morgan, Noel G

AU - Otonkoski, Timo

PY - 2017

Y1 - 2017

KW - CRISPR

KW - NEUROG3

KW - STAT3

KW - beta cell

KW - endocrine cells

KW - genome editing

KW - iPSC

KW - monogenic diabetes

KW - pancreatic differentiation

KW - stem cells

KW - CRISPR

KW - NEUROG3

KW - STAT3

KW - beta cell

KW - endocrine cells

KW - genome editing

KW - iPSC

KW - monogenic diabetes

KW - pancreatic differentiation

KW - stem cells

U2 - 10.1016/j.celrep.2017.03.055

DO - 10.1016/j.celrep.2017.03.055

M3 - Article

SN - 2211-1247

VL - 19

SP - 281

EP - 294

JO - Cell Reports

JF - Cell Reports

IS - 2

ER -