An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels

Sumanta Samanta; Vignesh K. Rangasami; N. Arul Murugan; Vijay Singh Parihar; Oommen P. Varghese; Oommen P. Oommen

doi:10.1039/d1py00013f

An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels

Sumanta Samanta, Vignesh K. Rangasami, N. Arul Murugan, Vijay Singh Parihar, Oommen P. Varghese, Oommen P. Oommen

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Abstract

We present here a new insight into the chemical reactivity and bioactivity of dopamine (DA) and gallic acid (GA) and their hyaluronic acid (HA) conjugates. Our data suggest that HA-GA scaffolds are superior to HA-DA, with higher oxidation kinetics, improved tissue adhesive properties, and radical scavenging ability with a lower pro-inflammatory response. This journal is

Original language	English
Pages (from-to)	2987-2991
Number of pages	5
Journal	Polymer Chemistry
Volume	12
Issue number	20
DOIs	https://doi.org/10.1039/d1py00013f
Publication status	Published - 2021
Publication type	A1 Journal article-refereed

Publication forum classification

Publication forum level 2

ASJC Scopus subject areas

Bioengineering
Biochemistry
Organic Chemistry
Polymers and Plastics

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10.1039/d1py00013fLicence: CC BY-NC

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title = "An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels",

abstract = "We present here a new insight into the chemical reactivity and bioactivity of dopamine (DA) and gallic acid (GA) and their hyaluronic acid (HA) conjugates. Our data suggest that HA-GA scaffolds are superior to HA-DA, with higher oxidation kinetics, improved tissue adhesive properties, and radical scavenging ability with a lower pro-inflammatory response. This journal is ",

author = "Sumanta Samanta and Rangasami, {Vignesh K.} and Murugan, {N. Arul} and Parihar, {Vijay Singh} and Varghese, {Oommen P.} and Oommen, {Oommen P.}",

note = "Funding Information: We acknowledge Dr Vijay Singh Parihar for assisting in the synthesis of the hydrazide derivative of gallic acid. We also acknowledge Begona Morras for assisting with the rheological measurement of the gels. SS thanks to the European Union{\textquoteright}s Horizon 2020 Marie Sklodowska-Curie Grant Program (Agreement No. 713645) for the financial support. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2021",

doi = "10.1039/d1py00013f",

language = "English",

volume = "12",

pages = "2987--2991",

journal = "Polymer Chemistry",

issn = "1759-9954",

publisher = "Royal Society of Chemistry",

number = "20",

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TY - JOUR

T1 - An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels

AU - Samanta, Sumanta

AU - Rangasami, Vignesh K.

AU - Murugan, N. Arul

AU - Parihar, Vijay Singh

AU - Varghese, Oommen P.

AU - Oommen, Oommen P.

N1 - Funding Information: We acknowledge Dr Vijay Singh Parihar for assisting in the synthesis of the hydrazide derivative of gallic acid. We also acknowledge Begona Morras for assisting with the rheological measurement of the gels. SS thanks to the European Union’s Horizon 2020 Marie Sklodowska-Curie Grant Program (Agreement No. 713645) for the financial support. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021

Y1 - 2021

N2 - We present here a new insight into the chemical reactivity and bioactivity of dopamine (DA) and gallic acid (GA) and their hyaluronic acid (HA) conjugates. Our data suggest that HA-GA scaffolds are superior to HA-DA, with higher oxidation kinetics, improved tissue adhesive properties, and radical scavenging ability with a lower pro-inflammatory response. This journal is

AB - We present here a new insight into the chemical reactivity and bioactivity of dopamine (DA) and gallic acid (GA) and their hyaluronic acid (HA) conjugates. Our data suggest that HA-GA scaffolds are superior to HA-DA, with higher oxidation kinetics, improved tissue adhesive properties, and radical scavenging ability with a lower pro-inflammatory response. This journal is

U2 - 10.1039/d1py00013f

DO - 10.1039/d1py00013f

M3 - Article

AN - SCOPUS:85106607738

SN - 1759-9954

VL - 12

SP - 2987

EP - 2991

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 20

ER -

An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels

Abstract

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