TY - JOUR
T1 - Antenatal interventions to reduce risk of low birth weight related to maternal infections during pregnancy
AU - Muthiani, Yvonne
AU - Hunter, Patricia J.
AU - Näsänen-Gilmore, Pieta K.
AU - Koivu, Annariina M.
AU - Isojärvi, Jaana
AU - Luoma, Juho
AU - Salenius, Meeri
AU - Hadji, Maryam
AU - Ashorn, Ulla
AU - Ashorn, Per
N1 - Funding Information:
This article is published as part of a supplement sponsored by Tampere University, Faculty of Medicine and Health Technology with grant support from the Children’s Investment Fund Foundation.
Funding Information:
The Children’s Investment Fund Foundation funded the study, Grant Reference Number 1808-02973 .
Funding Information:
The Children's Investment Fund Foundation funded the study, Grant Reference Number 1808-02973. This article is published as part of a supplement sponsored by Tampere University, Faculty of Medicine and Health Technology with grant support from the Children's Investment Fund Foundation.
Publisher Copyright:
© 2023 American Society for Nutrition
PY - 2023/6
Y1 - 2023/6
N2 - Background: Maternal infections during pregnancy have been linked to increased risk of adverse birth outcomes, including low birth weight (LBW), preterm birth (PTB), small for gestational age (SGA), and stillbirth (SB). Objectives: The purpose of this article was to summarize evidence from published literature on the effect of key interventions targeting maternal infections on adverse birth outcomes. Methods: We searched MEDLINE, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and CINAHL Complete between March 2020 and May 2020 with an update to cover until August 2022. We included randomized controlled trials (RCTs) and reviews of RCTs of 15 antenatal interventions for pregnant women reporting LBW, PTB, SGA, or SB as outcomes. Results: Of the 15 reviewed interventions, the administration of 3 or more doses of intermittent preventive treatment in pregnancy with sulphadoxine–pyrimethamine [IPTp-SP; RR: 0.80 (95% CI: 0.69, 0.94)] can reduce risk of LBW compared with 2 doses. The provision of insecticide-treated bed nets, periodontal treatment, and screening and treatment of asymptomatic bacteriuria may reduce risk of LBW. Maternal viral influenza vaccination, treatment of bacterial vaginosis, intermittent preventive treatment with dihydroartemisinin–piperaquine compared with IPTp-SP, and intermittent screening and treatment of malaria during pregnancy compared with IPTp were deemed unlikely to reduce the prevalence of adverse birth outcomes. Conclusions: At present, there is limited evidence from RCTs available for some potentially relevant interventions targeting maternal infections, which could be prioritized for future research.
AB - Background: Maternal infections during pregnancy have been linked to increased risk of adverse birth outcomes, including low birth weight (LBW), preterm birth (PTB), small for gestational age (SGA), and stillbirth (SB). Objectives: The purpose of this article was to summarize evidence from published literature on the effect of key interventions targeting maternal infections on adverse birth outcomes. Methods: We searched MEDLINE, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and CINAHL Complete between March 2020 and May 2020 with an update to cover until August 2022. We included randomized controlled trials (RCTs) and reviews of RCTs of 15 antenatal interventions for pregnant women reporting LBW, PTB, SGA, or SB as outcomes. Results: Of the 15 reviewed interventions, the administration of 3 or more doses of intermittent preventive treatment in pregnancy with sulphadoxine–pyrimethamine [IPTp-SP; RR: 0.80 (95% CI: 0.69, 0.94)] can reduce risk of LBW compared with 2 doses. The provision of insecticide-treated bed nets, periodontal treatment, and screening and treatment of asymptomatic bacteriuria may reduce risk of LBW. Maternal viral influenza vaccination, treatment of bacterial vaginosis, intermittent preventive treatment with dihydroartemisinin–piperaquine compared with IPTp-SP, and intermittent screening and treatment of malaria during pregnancy compared with IPTp were deemed unlikely to reduce the prevalence of adverse birth outcomes. Conclusions: At present, there is limited evidence from RCTs available for some potentially relevant interventions targeting maternal infections, which could be prioritized for future research.
KW - antenatal care
KW - low birth weight
KW - low- and middle-income countries
KW - maternal infections
KW - pregnancy
KW - preterm birth
KW - small for gestational age
KW - stillbirth
U2 - 10.1016/j.ajcnut.2023.02.025
DO - 10.1016/j.ajcnut.2023.02.025
M3 - Article
AN - SCOPUS:85161996613
SN - 0002-9165
VL - 117
SP - S118-S133
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - Supplement 2
ER -