Antibody Responses to Transglutaminase 3 in Dermatitis Herpetiformis: Lessons from Celiac Disease

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    Abstract

    Dermatitis herpetiformis (DH) is the skin manifestation of celiac disease, presenting with a blistering rash typically on the knees, elbows, buttocks and scalp. In both DH and celiac disease, exposure to dietary gluten triggers a cascade of events resulting in the production of autoantibodies against the transglutaminase (TG) enzyme, mainly TG2 but often also TG3. The latter is considered to be the primary autoantigen in DH. The dynamics of the development of the TG2-targeted autoimmune response have been studied in depth in celiac disease, but the immunological process underlying DH pathophysiology is incompletely understood. Part of this process is the occurrence of granular deposits of IgA and TG3 in the perilesional skin. While this serves as the primary diagnostic finding in DH, the role of these immunocomplexes in the pathogenesis is unknown. Intriguingly, even though gluten-intolerance likely develops initially in a similar manner in both DH and celiac disease, after the onset of the disease, its manifestations differ widely.

    Original languageEnglish
    Article number2910
    Number of pages11
    JournalInternational Journal of Molecular Sciences
    Volume23
    Issue number6
    DOIs
    Publication statusPublished - Mar 2022
    Publication typeA2 Review article in a scientific journal

    Keywords

    • Antibody Formation
    • Autoantibodies
    • Celiac Disease
    • Dermatitis Herpetiformis/pathology
    • Diet, Gluten-Free
    • Glutens
    • Humans
    • Immunoglobulin A
    • Transglutaminases

    Publication forum classification

    • Publication forum level 1

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