Antihypertensive therapy and arterial function in experimental hypertension

M Kähönen, H Mäkynen, I Pörsti, Pertti Arvola

Research output: Contribution to journalReview Articlepeer-review

Abstract

1. Alterations in the function of the endothelium and arterial smooth muscle may be important in the establishment of hypertension. Thus, the possible favorable influences of blood pressure-lowering agents on vascular responsiveness may be important in the chronic antihypertensive actions of these compounds. 2. A number of reports have suggested that ACE inhibitors can improve arterial function in hypertension, whereas the knowledge about the vascular effects of other antihypertensive drugs, like beta-blockers, calcium channel blockers, and diuretics remains rather limited. 3. In this article, the effects of antihypertensive therapy on arterial function in human and experimental hypertension are reviewed.

Original languageEnglish
Pages (from-to)221-238
Number of pages18
JournalGeneral Pharmacology
Volume27
Issue number2
DOIs
Publication statusPublished - Mar 1996
Externally publishedYes
Publication typeA2 Review article in a scientific journal

Keywords

  • Angiotensin-Converting Enzyme Inhibitors/pharmacology
  • Animals
  • Antihypertensive Agents/pharmacology
  • Arteries/drug effects
  • Endothelium, Vascular/drug effects
  • Humans
  • Hypertension/drug therapy
  • Muscle, Smooth, Vascular/drug effects
  • Vasodilation/drug effects

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