Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

Vanessa Schoissengeier, Lina Maqboul, Daniela Weber, Tilman Grune, Alexander Bürkle, Maria Moreno-Villaneuva, Claudio Franceschi, Miriam Capri, Jürgen Bernhard, Olivier Toussaint, Florence Debacq-Chainiaux, Birgit Weinberger, Efstathios S. Gonos, Ewa Sikora, Martijn Dollé, Eugène Jansen, P. Eline Slagboom, Antti Hervonen, Mikko Hurme, Nicolle BreusingJan Frank, Andrew C. Bulmer, Karl Heinz Wagner

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.

Original languageEnglish
Article number110234
JournalIscience
Volume27
Issue number7
DOIs
Publication statusPublished - 19 Jul 2024
Publication typeA1 Journal article-refereed

Keywords

  • human metabolism
  • pathology
  • public health

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • General

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