TY - JOUR
T1 - Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort
AU - Schoissengeier, Vanessa
AU - Maqboul, Lina
AU - Weber, Daniela
AU - Grune, Tilman
AU - Bürkle, Alexander
AU - Moreno-Villaneuva, Maria
AU - Franceschi, Claudio
AU - Capri, Miriam
AU - Bernhard, Jürgen
AU - Toussaint, Olivier
AU - Debacq-Chainiaux, Florence
AU - Weinberger, Birgit
AU - Gonos, Efstathios S.
AU - Sikora, Ewa
AU - Dollé, Martijn
AU - Jansen, Eugène
AU - Slagboom, P. Eline
AU - Hervonen, Antti
AU - Hurme, Mikko
AU - Breusing, Nicolle
AU - Frank, Jan
AU - Bulmer, Andrew C.
AU - Wagner, Karl Heinz
N1 - Publisher Copyright:
© 2024
PY - 2024/7/19
Y1 - 2024/7/19
N2 - Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.
AB - Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.
KW - human metabolism
KW - pathology
KW - public health
U2 - 10.1016/j.isci.2024.110234
DO - 10.1016/j.isci.2024.110234
M3 - Article
AN - SCOPUS:85196540049
SN - 2589-0042
VL - 27
JO - Iscience
JF - Iscience
IS - 7
M1 - 110234
ER -