Association between Circulating Retinol Binding Protein 4, Body Mass Index, and Biomarkers of Environmental Enteric Dysfunction among Slum-Dwelling Lean Adults in Bangladesh

Shah Mohammad Fahim; Md Amran Gazi; Md Ashraful Alam; Md Mehedi Hasan; Subhasish Das; Mustafa Mahfuz; Tahmeed Ahmed

doi:10.4269/ajtmh.21-0322

Association between Circulating Retinol Binding Protein 4, Body Mass Index, and Biomarkers of Environmental Enteric Dysfunction among Slum-Dwelling Lean Adults in Bangladesh

Shah Mohammad Fahim^*
, Md Amran Gazi
, Md Ashraful Alam
, Md Mehedi Hasan
, Subhasish Das
, Mustafa Mahfuz
, Tahmeed Ahmed

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

1 Citation (Scopus)

9 Downloads (Pure)

Abstract

The relationship of retinol binding protein 4 (RBP4) with biomarkers of intestinal health and gut integrity in adults is unknown. We sought to determine the correlation between plasma RBP4 level and BMI and investigate the relationship of circulating RBP4 concentration with biomarkers of environmental enteric dysfunction among lean adults (body mass index [BMI] < 25.0 kg/m²) in Bangladesh. Overall, 270 adults (135 undernourished with a BMI < 18.5 kg/m² and 135 healthy controls with a BMI between 18.5 and 24.9 kg/m²) aged 18 to 45 years were evaluated. Multivariable linear regression was performed to test the association between RBP4 and fecal biomarkers of impaired gut health. RBP4 concentration was positively correlated (rho = 0.27, P < 0.001) with BMI and was significantly higher in healthy controls than undernourished adults (P < 0.001), in male than female (P < 0.001), and also in employed (P < 0.001), smokers (P = 0.048) and participants with low Self-Reporting Questionnaire (SRQ)—20 scores (an instrument to screen mental health disorders) (P = 0.049). Statistically significant negative correlations were observed between RBP4 and fecal biomarkers of gut enteropathy including myeloperoxidase (rho = –0.23, P < 0.001), neopterin (rho = –0.30, P < 0.001), and alpha-1 anti-trypsin (rho = –0.21, P < 0.001). Multivariable linear regression analysis showed that increased RBP4 concentration was associated with a significant reduction in fecal neopterin (coefficient = –0.95; 95% confidence interval: –1.44 to –0.45]; P < 0.001) after adjustment for age, sex, nutritional status at enrollment, education, dietary diversity score, SRQ-20 score, improved sanitation, household animal exposure, and alpha-1-acid glycoprotein. The study findings revealed an inverse relationship of plasma RBP4 concentration with fecal biomarkers of altered gut health among slum-dwelling lean adults in Bangladesh.

Original language	English
Pages (from-to)	1315-1322
Number of pages	8
Journal	American Journal of Tropical Medicine and Hygiene
Volume	107
Issue number	6
DOIs	https://doi.org/10.4269/ajtmh.21-0322
Publication status	Published - 2022
Publication type	A1 Journal article-refereed

Funding

Financial support: This protocol is supported by the BMGF under its Global Health Program. The project investment ID is OPP1136751 (https://www.gatesfoundation.org/How-We-Work/Quick-Links/Grants Database/Grants/2015/11/OPP1136751). The donor had no role in the study design; collection, analysis, and interpretation of data; preparation, review, or approval of the manuscript; and decision to submit and publish the manuscript.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 2 Zero Hunger
SDG 3 Good Health and Well-being

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Parasitology
Infectious Diseases
Virology

Access to Document

10.4269/ajtmh.21-0322Licence: CC BY

1476-1645-article-p1315Final published version, 1.03 MBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202301121359Licence: CC BY

Cite this

Fahim, S. M., Amran Gazi, M., Ashraful Alam, M., Mehedi Hasan, M., Das, S., Mahfuz, M., & Ahmed, T. (2022). Association between Circulating Retinol Binding Protein 4, Body Mass Index, and Biomarkers of Environmental Enteric Dysfunction among Slum-Dwelling Lean Adults in Bangladesh. American Journal of Tropical Medicine and Hygiene, 107(6), 1315-1322. https://doi.org/10.4269/ajtmh.21-0322

@article{10fefcc41bb243d6a705168f08768a8e,

title = "Association between Circulating Retinol Binding Protein 4, Body Mass Index, and Biomarkers of Environmental Enteric Dysfunction among Slum-Dwelling Lean Adults in Bangladesh",

abstract = "The relationship of retinol binding protein 4 (RBP4) with biomarkers of intestinal health and gut integrity in adults is unknown. We sought to determine the correlation between plasma RBP4 level and BMI and investigate the relationship of circulating RBP4 concentration with biomarkers of environmental enteric dysfunction among lean adults (body mass index [BMI] < 25.0 kg/m2) in Bangladesh. Overall, 270 adults (135 undernourished with a BMI < 18.5 kg/m2 and 135 healthy controls with a BMI between 18.5 and 24.9 kg/m2) aged 18 to 45 years were evaluated. Multivariable linear regression was performed to test the association between RBP4 and fecal biomarkers of impaired gut health. RBP4 concentration was positively correlated (rho = 0.27, P < 0.001) with BMI and was significantly higher in healthy controls than undernourished adults (P < 0.001), in male than female (P < 0.001), and also in employed (P < 0.001), smokers (P = 0.048) and participants with low Self-Reporting Questionnaire (SRQ)—20 scores (an instrument to screen mental health disorders) (P = 0.049). Statistically significant negative correlations were observed between RBP4 and fecal biomarkers of gut enteropathy including myeloperoxidase (rho = –0.23, P < 0.001), neopterin (rho = –0.30, P < 0.001), and alpha-1 anti-trypsin (rho = –0.21, P < 0.001). Multivariable linear regression analysis showed that increased RBP4 concentration was associated with a significant reduction in fecal neopterin (coefficient = –0.95; 95\% confidence interval: –1.44 to –0.45]; P < 0.001) after adjustment for age, sex, nutritional status at enrollment, education, dietary diversity score, SRQ-20 score, improved sanitation, household animal exposure, and alpha-1-acid glycoprotein. The study findings revealed an inverse relationship of plasma RBP4 concentration with fecal biomarkers of altered gut health among slum-dwelling lean adults in Bangladesh.",

author = "Fahim, \{Shah Mohammad\} and \{Amran Gazi\}, Md and \{Ashraful Alam\}, Md and \{Mehedi Hasan\}, Md and Subhasish Das and Mustafa Mahfuz and Tahmeed Ahmed",

note = "Funding Information: Financial support: This protocol is supported by the BMGF under its Global Health Program. The project investment ID is OPP1136751 (https://www.gatesfoundation.org/How-We-Work/Quick-Links/Grants Database/Grants/2015/11/OPP1136751). The donor had no role in the study design; collection, analysis, and interpretation of data; preparation, review, or approval of the manuscript; and decision to submit and publish the manuscript. Publisher Copyright: Copyright {\textcopyright} 2022 The author(s)",

year = "2022",

doi = "10.4269/ajtmh.21-0322",

language = "English",

volume = "107",

pages = "1315--1322",

journal = "American Journal of Tropical Medicine and Hygiene",

issn = "0002-9637",

publisher = "American Society of Tropical Medicine and Hygiene",

number = "6",

}

Fahim, SM, Amran Gazi, M, Ashraful Alam, M, Mehedi Hasan, M, Das, S, Mahfuz, M & Ahmed, T 2022, 'Association between Circulating Retinol Binding Protein 4, Body Mass Index, and Biomarkers of Environmental Enteric Dysfunction among Slum-Dwelling Lean Adults in Bangladesh', American Journal of Tropical Medicine and Hygiene, vol. 107, no. 6, pp. 1315-1322. https://doi.org/10.4269/ajtmh.21-0322

Association between Circulating Retinol Binding Protein 4, Body Mass Index, and Biomarkers of Environmental Enteric Dysfunction among Slum-Dwelling Lean Adults in Bangladesh. / Fahim, Shah Mohammad; Amran Gazi, Md; Ashraful Alam, Md et al.
In: American Journal of Tropical Medicine and Hygiene, Vol. 107, No. 6, 2022, p. 1315-1322.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Association between Circulating Retinol Binding Protein 4, Body Mass Index, and Biomarkers of Environmental Enteric Dysfunction among Slum-Dwelling Lean Adults in Bangladesh

AU - Fahim, Shah Mohammad

AU - Amran Gazi, Md

AU - Ashraful Alam, Md

AU - Mehedi Hasan, Md

AU - Das, Subhasish

AU - Mahfuz, Mustafa

AU - Ahmed, Tahmeed

N1 - Funding Information: Financial support: This protocol is supported by the BMGF under its Global Health Program. The project investment ID is OPP1136751 (https://www.gatesfoundation.org/How-We-Work/Quick-Links/Grants Database/Grants/2015/11/OPP1136751). The donor had no role in the study design; collection, analysis, and interpretation of data; preparation, review, or approval of the manuscript; and decision to submit and publish the manuscript. Publisher Copyright: Copyright © 2022 The author(s)

PY - 2022

Y1 - 2022

N2 - The relationship of retinol binding protein 4 (RBP4) with biomarkers of intestinal health and gut integrity in adults is unknown. We sought to determine the correlation between plasma RBP4 level and BMI and investigate the relationship of circulating RBP4 concentration with biomarkers of environmental enteric dysfunction among lean adults (body mass index [BMI] < 25.0 kg/m2) in Bangladesh. Overall, 270 adults (135 undernourished with a BMI < 18.5 kg/m2 and 135 healthy controls with a BMI between 18.5 and 24.9 kg/m2) aged 18 to 45 years were evaluated. Multivariable linear regression was performed to test the association between RBP4 and fecal biomarkers of impaired gut health. RBP4 concentration was positively correlated (rho = 0.27, P < 0.001) with BMI and was significantly higher in healthy controls than undernourished adults (P < 0.001), in male than female (P < 0.001), and also in employed (P < 0.001), smokers (P = 0.048) and participants with low Self-Reporting Questionnaire (SRQ)—20 scores (an instrument to screen mental health disorders) (P = 0.049). Statistically significant negative correlations were observed between RBP4 and fecal biomarkers of gut enteropathy including myeloperoxidase (rho = –0.23, P < 0.001), neopterin (rho = –0.30, P < 0.001), and alpha-1 anti-trypsin (rho = –0.21, P < 0.001). Multivariable linear regression analysis showed that increased RBP4 concentration was associated with a significant reduction in fecal neopterin (coefficient = –0.95; 95% confidence interval: –1.44 to –0.45]; P < 0.001) after adjustment for age, sex, nutritional status at enrollment, education, dietary diversity score, SRQ-20 score, improved sanitation, household animal exposure, and alpha-1-acid glycoprotein. The study findings revealed an inverse relationship of plasma RBP4 concentration with fecal biomarkers of altered gut health among slum-dwelling lean adults in Bangladesh.

AB - The relationship of retinol binding protein 4 (RBP4) with biomarkers of intestinal health and gut integrity in adults is unknown. We sought to determine the correlation between plasma RBP4 level and BMI and investigate the relationship of circulating RBP4 concentration with biomarkers of environmental enteric dysfunction among lean adults (body mass index [BMI] < 25.0 kg/m2) in Bangladesh. Overall, 270 adults (135 undernourished with a BMI < 18.5 kg/m2 and 135 healthy controls with a BMI between 18.5 and 24.9 kg/m2) aged 18 to 45 years were evaluated. Multivariable linear regression was performed to test the association between RBP4 and fecal biomarkers of impaired gut health. RBP4 concentration was positively correlated (rho = 0.27, P < 0.001) with BMI and was significantly higher in healthy controls than undernourished adults (P < 0.001), in male than female (P < 0.001), and also in employed (P < 0.001), smokers (P = 0.048) and participants with low Self-Reporting Questionnaire (SRQ)—20 scores (an instrument to screen mental health disorders) (P = 0.049). Statistically significant negative correlations were observed between RBP4 and fecal biomarkers of gut enteropathy including myeloperoxidase (rho = –0.23, P < 0.001), neopterin (rho = –0.30, P < 0.001), and alpha-1 anti-trypsin (rho = –0.21, P < 0.001). Multivariable linear regression analysis showed that increased RBP4 concentration was associated with a significant reduction in fecal neopterin (coefficient = –0.95; 95% confidence interval: –1.44 to –0.45]; P < 0.001) after adjustment for age, sex, nutritional status at enrollment, education, dietary diversity score, SRQ-20 score, improved sanitation, household animal exposure, and alpha-1-acid glycoprotein. The study findings revealed an inverse relationship of plasma RBP4 concentration with fecal biomarkers of altered gut health among slum-dwelling lean adults in Bangladesh.

U2 - 10.4269/ajtmh.21-0322

DO - 10.4269/ajtmh.21-0322

M3 - Article

C2 - 36216318

AN - SCOPUS:85144442303

SN - 0002-9637

VL - 107

SP - 1315

EP - 1322

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 6

ER -

Association between Circulating Retinol Binding Protein 4, Body Mass Index, and Biomarkers of Environmental Enteric Dysfunction among Slum-Dwelling Lean Adults in Bangladesh

Abstract

Funding

UN SDGs

Publication forum classification

ASJC Scopus subject areas

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