TY - JOUR
T1 - Association between dietary fat intake and colorectal cancer
T2 - A multicenter case-control study in Iran
AU - Seyyedsalehi, Monireh Sadat
AU - Collatuzzo, Giulia
AU - Huybrechts, Inge
AU - Hadji, Maryam
AU - Rashidian, Hamideh
AU - Safari-Faramani, Roya
AU - Alizadeh-Navaei, Reza
AU - Kamangar, Farin
AU - Etemadi, Arash
AU - Pukkala, Eero
AU - Gunter, Marc J.
AU - Chajes, Veronique
AU - Boffetta, Paolo
AU - Zendehdel, Kazem
N1 - Funding Information:
This study was funded by National Institute of Medical Research Development (NIMAD) (Code: IR.NIMAD.REC.1394.027) and particularly supported by Investigator Grant No. 24706 of Fondazione AIRC. Italy.
Publisher Copyright:
Copyright © 2022 Seyyedsalehi, Collatuzzo, Huybrechts, Hadji, Rashidian, Safari-Faramani, Alizadeh-Navaei, Kamangar, Etemadi, Pukkala, Gunter, Chajes, Boffetta and Zendehdel.
PY - 2022/11/16
Y1 - 2022/11/16
N2 - The evolving trends in colorectal cancer (CRC) as one of the most common malignancies worldwide, have likely been influenced by the implementation of screening programs and changes in lifestyle habits. Changing lifestyle, including the shift in diet composition with higher fat, sugar, and animal-source foods intake, led to an increasing burden of CRC in countries undergoing rapid socioeconomic improvement. Results for the link between specific fatty acids (FAs) and CRC are generally inconclusive and more limited in developing countries than elsewhere. This study aims to investigate the association between FA intakes and CRC and its anatomical subsites in a large Iranian case-control study. A food frequency questionnaire was used to collect information on dietary intake in 865 cases and 3206 controls. We conducted multivariate logistic regression models to calculate the odds ratio (OR) and 95% confidence interval (CI). We found positive association between CRC and high intake of dietary total fat (OR highest quartile Q4 = 1.77, 95% CI = 1.32–2.38), cholesterol (ORQ4 = 1.58, 95% CI = 1.22–2.05), and palmitoleic acid (ORQ4 = 2.16, 95% CI = 1.19, 3.91), and an inverse association with high intake of dietary heptanoic acid (ORQ4 = 0.33, 95% CI = 0.14, 0.79) and low intake of palmitic acid (OR lowest quartile Q2 = 0.53, 95% CI = 0.31–0.88). None of the fat variables were associated with rectal cancer. Our study suggests that the recommendation of limited consumption of fats may decrease the risk of CRC among the Iranian population.
AB - The evolving trends in colorectal cancer (CRC) as one of the most common malignancies worldwide, have likely been influenced by the implementation of screening programs and changes in lifestyle habits. Changing lifestyle, including the shift in diet composition with higher fat, sugar, and animal-source foods intake, led to an increasing burden of CRC in countries undergoing rapid socioeconomic improvement. Results for the link between specific fatty acids (FAs) and CRC are generally inconclusive and more limited in developing countries than elsewhere. This study aims to investigate the association between FA intakes and CRC and its anatomical subsites in a large Iranian case-control study. A food frequency questionnaire was used to collect information on dietary intake in 865 cases and 3206 controls. We conducted multivariate logistic regression models to calculate the odds ratio (OR) and 95% confidence interval (CI). We found positive association between CRC and high intake of dietary total fat (OR highest quartile Q4 = 1.77, 95% CI = 1.32–2.38), cholesterol (ORQ4 = 1.58, 95% CI = 1.22–2.05), and palmitoleic acid (ORQ4 = 2.16, 95% CI = 1.19, 3.91), and an inverse association with high intake of dietary heptanoic acid (ORQ4 = 0.33, 95% CI = 0.14, 0.79) and low intake of palmitic acid (OR lowest quartile Q2 = 0.53, 95% CI = 0.31–0.88). None of the fat variables were associated with rectal cancer. Our study suggests that the recommendation of limited consumption of fats may decrease the risk of CRC among the Iranian population.
KW - colorectal cancer
KW - diet
KW - fat
KW - food frequency questionnaire
KW - gastrointestinal neoplasms
U2 - 10.3389/fnut.2022.1017720
DO - 10.3389/fnut.2022.1017720
M3 - Article
AN - SCOPUS:85142651667
VL - 9
M1 - 1017720
ER -
