TY - JOUR
T1 - Association Between TTV Viremia, Chronic Inflammation, and Ischemic Heart Disease Risk
T2 - Insights From MARK-AGE and Report-Age Projects
AU - Giacconi, Robertina
AU - Piacenza, Francesco
AU - Maggi, Fabrizio
AU - Bürkle, Alexander
AU - Moreno-Villanueva, María
AU - Mancinelli, Lucia
AU - Spezia, Pietro Giorgio
AU - Novazzi, Federica
AU - Ferrante, Francesca Drago
AU - Minosse, Claudia
AU - Grossi, Paolo Antonio
AU - Mancini, Nicasio
AU - Cecati, Monia
AU - Dollé, Martijn E.T.
AU - Jansen, Eugène
AU - Grune, Tilman
AU - Gonos, Efstathios S.
AU - Franceschi, Claudio
AU - Capri, Miriam
AU - Weinberger, Birgit
AU - Sikora, Ewa
AU - Debacq-Chainiaux, Florence
AU - Stuetz, Wolfgang
AU - Hurme, Mikko
AU - Eline Slagboom, P.
AU - Bernhardt, Jürgen
AU - Gentilini, Davide
AU - Calzari, Luciano
AU - Di Rosa, Mirko
AU - Bonfigli, Anna Rita
AU - Galeazzi, Roberta
AU - Cherubini, Antonio
AU - Lattanzio, Fabrizia
AU - Provinciali, Mauro
AU - Malavolta, Marco
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/11
Y1 - 2024/11
N2 - The implication of Torquetenovirus (TTV) in ischemic heart disease (IHD) has not been thoroughly explored. This study investigated the association between TTV viremia, pro-inflammatory cytokines, and IHD risk in an aging population. This cross-sectional study included 900 non-IHD subjects and 86 individuals with IHD (aged 55–75 years) selected from the MARK-AGE project. Results were verified in another independent Report-Age cohort, including 94 inpatients with chronic IHD and 111 inpatients with non-IHD (aged 65–96 years). Multivariable logistic regression in the MARK-AGE cohort revealed that male sex, TTV viremia ≥4log, Cu/Zn ratio, diabetes, hypertension, and smoking were significant IHD predictors. Notably, TTV viremia ≥4log independently increased the IHD risk (odds ratio [OR]: 2.51, 95% confidence interval [CI]: 1.42–4.43), confirmed in the Report-Age cohort (OR: 4.90, 95% CI: 2.32–10.39). In a RASIG subgroup, individuals with TTV viremia ≥4 log, both with and without IHD, exhibited increased plasma pro-inflammatory cytokine levels (IFN-γ, IL-1β, IL-6, IL-10, IL-12p70, TNF-α) compared to those with TTV viremia <4 log. No significant difference in cytokine production was observed between IHD patients and non-IHD with TTV viremia ≥4 log. A positive correlation between TTV viremia and DNA methylation estimator of leukocyte telomere length was observed in Report-Age patients. Additionally, IHD Report-Age patients with TTV viremia ≥4 log displayed higher NLR and SIRI index than those with TTV viremia <4 log. In conclusion, a high TTV viremia is associated with an elevated IHD risk in the older population, potentially arising from an augmented pro-inflammatory response and immunosenescence.
AB - The implication of Torquetenovirus (TTV) in ischemic heart disease (IHD) has not been thoroughly explored. This study investigated the association between TTV viremia, pro-inflammatory cytokines, and IHD risk in an aging population. This cross-sectional study included 900 non-IHD subjects and 86 individuals with IHD (aged 55–75 years) selected from the MARK-AGE project. Results were verified in another independent Report-Age cohort, including 94 inpatients with chronic IHD and 111 inpatients with non-IHD (aged 65–96 years). Multivariable logistic regression in the MARK-AGE cohort revealed that male sex, TTV viremia ≥4log, Cu/Zn ratio, diabetes, hypertension, and smoking were significant IHD predictors. Notably, TTV viremia ≥4log independently increased the IHD risk (odds ratio [OR]: 2.51, 95% confidence interval [CI]: 1.42–4.43), confirmed in the Report-Age cohort (OR: 4.90, 95% CI: 2.32–10.39). In a RASIG subgroup, individuals with TTV viremia ≥4 log, both with and without IHD, exhibited increased plasma pro-inflammatory cytokine levels (IFN-γ, IL-1β, IL-6, IL-10, IL-12p70, TNF-α) compared to those with TTV viremia <4 log. No significant difference in cytokine production was observed between IHD patients and non-IHD with TTV viremia ≥4 log. A positive correlation between TTV viremia and DNA methylation estimator of leukocyte telomere length was observed in Report-Age patients. Additionally, IHD Report-Age patients with TTV viremia ≥4 log displayed higher NLR and SIRI index than those with TTV viremia <4 log. In conclusion, a high TTV viremia is associated with an elevated IHD risk in the older population, potentially arising from an augmented pro-inflammatory response and immunosenescence.
KW - Aging
KW - Inflammation
KW - Ischemic heart disease
KW - Torquetenovirus
U2 - 10.1093/gerona/glae228
DO - 10.1093/gerona/glae228
M3 - Article
C2 - 39446526
AN - SCOPUS:85208515726
SN - 1079-5006
VL - 79
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 11
M1 - glae228
ER -