Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother–infant dyads

Sharika Nuzhat; Parag Palit; Mustafa Mahfuz; Md. Ridwan Islam; S. M. Tafsir Hasan; M. Munirul Islam; Shafiqul A. Sarker; David J. Kyle; Robin L. Flannery; Anita Vinjamuri; Carlito B. Lebrilla; Tahmeed Ahmed

doi:10.1038/s41598-022-13296-w

Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother–infant dyads

Sharika Nuzhat, Parag Palit, Mustafa Mahfuz, Md. Ridwan Islam, S. M. Tafsir Hasan, M. Munirul Islam, Shafiqul A. Sarker, David J. Kyle, Robin L. Flannery, Anita Vinjamuri, Carlito B. Lebrilla, Tahmeed Ahmed

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Abstract

Human milk oligosaccharides (HMOs) support the development of a healthy gut microbiome and the growth of infants. We aimed to determine the association of different HMOs with severe acute malnutrition (SAM) among Bangladeshi young infants. This study was nested within a single-blind, randomized, pilot clinical trial (NCT0366657). A total of 45 breastmilk samples from mothers of < 6 months old infants who had SAM (n = 26) or were non-malnourished (n = 19) and were analyzed for constituent HMOs. Of the infants with SAM, 14 (53.85%) had secretor mothers, and 11 (57.89%) of the non-malnourished infants had secretor mothers. A one-unit increase in the relative abundance of sialylated HMOs was associated with higher odds of SAM in age and sex adjusted model (aOR = 2.00, 90% CI 1.30, 3.06), in age, sex, and secretor status adjusted model (aOR = 1.96, 90% CI 1.29, 2.98), and also in age and sex adjusted model among non-secretor mothers (aOR = 2.86, 90% CI 1.07, 7.62). In adjusted models, there was no evidence of a statistically significant association between SAM and fucosylated or undecorated HMOs. Our study demonstrates that a higher relative abundance of sialylated HMOs in mothers’ breastmilk may have a negative impact on young infants’ nutritional status.

Original language	English
Article number	9456
Number of pages	9
Journal	Scientific Reports
Volume	12
DOIs	https://doi.org/10.1038/s41598-022-13296-w
Publication status	Published - Jun 2022
Publication type	A1 Journal article-refereed

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General

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Nuzhat, S., Palit, P., Mahfuz, M., Islam, M. R., Hasan, S. M. T., Islam, M. M., Sarker, S. A., Kyle, D. J., Flannery, R. L., Vinjamuri, A., Lebrilla, C. B., & Ahmed, T. (2022). Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother–infant dyads. Scientific Reports, 12, Article 9456. https://doi.org/10.1038/s41598-022-13296-w

@article{4769ebba0ef04570a41e166fa5bc63e1,

title = "Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother–infant dyads",

abstract = "Human milk oligosaccharides (HMOs) support the development of a healthy gut microbiome and the growth of infants. We aimed to determine the association of different HMOs with severe acute malnutrition (SAM) among Bangladeshi young infants. This study was nested within a single-blind, randomized, pilot clinical trial (NCT0366657). A total of 45 breastmilk samples from mothers of < 6 months old infants who had SAM (n = 26) or were non-malnourished (n = 19) and were analyzed for constituent HMOs. Of the infants with SAM, 14 (53.85%) had secretor mothers, and 11 (57.89%) of the non-malnourished infants had secretor mothers. A one-unit increase in the relative abundance of sialylated HMOs was associated with higher odds of SAM in age and sex adjusted model (aOR = 2.00, 90% CI 1.30, 3.06), in age, sex, and secretor status adjusted model (aOR = 1.96, 90% CI 1.29, 2.98), and also in age and sex adjusted model among non-secretor mothers (aOR = 2.86, 90% CI 1.07, 7.62). In adjusted models, there was no evidence of a statistically significant association between SAM and fucosylated or undecorated HMOs. Our study demonstrates that a higher relative abundance of sialylated HMOs in mothers{\textquoteright} breastmilk may have a negative impact on young infants{\textquoteright} nutritional status.",

author = "Sharika Nuzhat and Parag Palit and Mustafa Mahfuz and Islam, {Md. Ridwan} and Hasan, {S. M. Tafsir} and Islam, {M. Munirul} and Sarker, {Shafiqul A.} and Kyle, {David J.} and Flannery, {Robin L.} and Anita Vinjamuri and Lebrilla, {Carlito B.} and Tahmeed Ahmed",

note = "Funding Information: The authors sincerely thank the study participants and their families for adherence to the rigorous study guidelines. This research protocol/activity/study was funded by Bill and Melinda Gates Foundation, grant number OPP1179599. icddr,b acknowledges with gratitude the commitment of BMGF to its research efforts. icddr,b is also grateful to the Governments of Bangladesh, Canada, Sweden and the UK for providing core/unrestricted support. Funding Information: The authors sincerely thank the study participants and their families for adherence to the rigorous study guidelines. This research protocol/activity/study was funded by Bill and Melinda Gates Foundation, grant number OPP1179599. icddr,b acknowledges with gratitude the commitment of BMGF to its research efforts. icddr,b is also grateful to the Governments of Bangladesh, Canada, Sweden and the UK for providing core/unrestricted support. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = jun,

doi = "10.1038/s41598-022-13296-w",

language = "English",

volume = "12",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Research",

}

TY - JOUR

T1 - Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother–infant dyads

AU - Nuzhat, Sharika

AU - Palit, Parag

AU - Mahfuz, Mustafa

AU - Islam, Md. Ridwan

AU - Hasan, S. M. Tafsir

AU - Islam, M. Munirul

AU - Sarker, Shafiqul A.

AU - Kyle, David J.

AU - Flannery, Robin L.

AU - Vinjamuri, Anita

AU - Lebrilla, Carlito B.

AU - Ahmed, Tahmeed

N1 - Funding Information: The authors sincerely thank the study participants and their families for adherence to the rigorous study guidelines. This research protocol/activity/study was funded by Bill and Melinda Gates Foundation, grant number OPP1179599. icddr,b acknowledges with gratitude the commitment of BMGF to its research efforts. icddr,b is also grateful to the Governments of Bangladesh, Canada, Sweden and the UK for providing core/unrestricted support. Funding Information: The authors sincerely thank the study participants and their families for adherence to the rigorous study guidelines. This research protocol/activity/study was funded by Bill and Melinda Gates Foundation, grant number OPP1179599. icddr,b acknowledges with gratitude the commitment of BMGF to its research efforts. icddr,b is also grateful to the Governments of Bangladesh, Canada, Sweden and the UK for providing core/unrestricted support. Publisher Copyright: © 2022, The Author(s).

PY - 2022/6

Y1 - 2022/6

N2 - Human milk oligosaccharides (HMOs) support the development of a healthy gut microbiome and the growth of infants. We aimed to determine the association of different HMOs with severe acute malnutrition (SAM) among Bangladeshi young infants. This study was nested within a single-blind, randomized, pilot clinical trial (NCT0366657). A total of 45 breastmilk samples from mothers of < 6 months old infants who had SAM (n = 26) or were non-malnourished (n = 19) and were analyzed for constituent HMOs. Of the infants with SAM, 14 (53.85%) had secretor mothers, and 11 (57.89%) of the non-malnourished infants had secretor mothers. A one-unit increase in the relative abundance of sialylated HMOs was associated with higher odds of SAM in age and sex adjusted model (aOR = 2.00, 90% CI 1.30, 3.06), in age, sex, and secretor status adjusted model (aOR = 1.96, 90% CI 1.29, 2.98), and also in age and sex adjusted model among non-secretor mothers (aOR = 2.86, 90% CI 1.07, 7.62). In adjusted models, there was no evidence of a statistically significant association between SAM and fucosylated or undecorated HMOs. Our study demonstrates that a higher relative abundance of sialylated HMOs in mothers’ breastmilk may have a negative impact on young infants’ nutritional status.

AB - Human milk oligosaccharides (HMOs) support the development of a healthy gut microbiome and the growth of infants. We aimed to determine the association of different HMOs with severe acute malnutrition (SAM) among Bangladeshi young infants. This study was nested within a single-blind, randomized, pilot clinical trial (NCT0366657). A total of 45 breastmilk samples from mothers of < 6 months old infants who had SAM (n = 26) or were non-malnourished (n = 19) and were analyzed for constituent HMOs. Of the infants with SAM, 14 (53.85%) had secretor mothers, and 11 (57.89%) of the non-malnourished infants had secretor mothers. A one-unit increase in the relative abundance of sialylated HMOs was associated with higher odds of SAM in age and sex adjusted model (aOR = 2.00, 90% CI 1.30, 3.06), in age, sex, and secretor status adjusted model (aOR = 1.96, 90% CI 1.29, 2.98), and also in age and sex adjusted model among non-secretor mothers (aOR = 2.86, 90% CI 1.07, 7.62). In adjusted models, there was no evidence of a statistically significant association between SAM and fucosylated or undecorated HMOs. Our study demonstrates that a higher relative abundance of sialylated HMOs in mothers’ breastmilk may have a negative impact on young infants’ nutritional status.

U2 - 10.1038/s41598-022-13296-w

DO - 10.1038/s41598-022-13296-w

M3 - Article

C2 - 35676397

AN - SCOPUS:85131653355

SN - 2045-2322

VL - 12

JO - Scientific Reports

JF - Scientific Reports

M1 - 9456

ER -

Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother–infant dyads

Abstract

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