Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)

Niku Oksala; Jenita Pärssinen; Ilkka Seppälä; Emma Raitoharju; Kholova Ivana; Jussi Hernesniemi; Leo Pekka Lyytikäinen; Mari Levula; Kari Matti Mäkelä; Thanos Sioris; Mika Kähönen; Reijo Laaksonen; Vesa Hytönen; Terho Lehtimäki

doi:10.1161/circgenetics.113.000141

Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)

Niku Oksala, Jenita Pärssinen, Ilkka Seppälä, Emma Raitoharju, Kholova Ivana, Jussi Hernesniemi, Leo Pekka Lyytikäinen, Mari Levula, Kari Matti Mäkelä, Thanos Sioris, Mika Kähönen, Reijo Laaksonen, Vesa Hytönen, Terho Lehtimäki

Research output: Contribution to journal › Article › Scientific › peer-review

26 Citations (Scopus)

Abstract

Background-Macrophage (MF) infiltration and smooth muscle cell (SMC) proliferation are hallmarks of atherosclerosis and unstable plaques. Neuroimmune guidance cue 1 (netrin-1 [NTN1]) plays a critical role controlling MF trafficking and SMC activation. Characterization of expression of NTN1 and its receptors and their association with plaque stability in human(s) is lacking. Methods and Results-The expression of NTN1 and its receptors did not differ in either whole blood or circulating monocytes from patients with coronary artery disease (n=55) compared with healthy controls (n=45). However, NTN1 was downregulated (-2.9-fold: P

Original language	English
Pages (from-to)	579-587
Number of pages	9
Journal	Circulation: Cardiovascular Genetics
Volume	6
Issue number	6
DOIs	https://doi.org/10.1161/circgenetics.113.000141
Publication status	Published - 2013
Publication type	A1 Journal article-refereed

Keywords

Atherosclerosis
Gene expression
Immunohistochemistry
Macrophages
Myocytes
Smooth muscle
Whole genome association analysis

Publication forum classification

Publication forum level 1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/circgenetics.113.000141

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Oksala, N., Pärssinen, J., Seppälä, I., Raitoharju, E., Ivana, K., Hernesniemi, J., Lyytikäinen, L. P., Levula, M., Mäkelä, K. M., Sioris, T., Kähönen, M., Laaksonen, R., Hytönen, V., & Lehtimäki, T. (2013). Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS). Circulation: Cardiovascular Genetics, 6(6), 579-587. https://doi.org/10.1161/circgenetics.113.000141

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title = "Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)",

abstract = "Background-Macrophage (MF) infiltration and smooth muscle cell (SMC) proliferation are hallmarks of atherosclerosis and unstable plaques. Neuroimmune guidance cue 1 (netrin-1 [NTN1]) plays a critical role controlling MF trafficking and SMC activation. Characterization of expression of NTN1 and its receptors and their association with plaque stability in human(s) is lacking. Methods and Results-The expression of NTN1 and its receptors did not differ in either whole blood or circulating monocytes from patients with coronary artery disease (n=55) compared with healthy controls (n=45). However, NTN1 was downregulated (-2.9-fold: P",

keywords = "Atherosclerosis, Gene expression, Immunohistochemistry, Macrophages, Myocytes, Smooth muscle, Whole genome association analysis, Atherosclerosis, Gene expression, Immunohistochemistry, Macrophages, Myocytes, Smooth muscle, Whole genome association analysis",

author = "Niku Oksala and Jenita P{\"a}rssinen and Ilkka Sepp{\"a}l{\"a} and Emma Raitoharju and Kholova Ivana and Jussi Hernesniemi and Lyytik{\"a}inen, {Leo Pekka} and Mari Levula and M{\"a}kel{\"a}, {Kari Matti} and Thanos Sioris and Mika K{\"a}h{\"o}nen and Reijo Laaksonen and Vesa Hyt{\"o}nen and Terho Lehtim{\"a}ki",

year = "2013",

doi = "10.1161/circgenetics.113.000141",

language = "English",

volume = "6",

pages = "579--587",

journal = "Circulation: Cardiovascular Genetics",

issn = "1942-325X",

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Oksala, N, Pärssinen, J, Seppälä, I, Raitoharju, E , Ivana, K , Hernesniemi, J , Lyytikäinen, LP, Levula, M, Mäkelä, KM, Sioris, T, Kähönen, M , Laaksonen, R , Hytönen, V & Lehtimäki, T 2013, 'Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)', Circulation: Cardiovascular Genetics, vol. 6, no. 6, pp. 579-587. https://doi.org/10.1161/circgenetics.113.000141

Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS). / Oksala, Niku; Pärssinen, Jenita; Seppälä, Ilkka et al.

In: Circulation: Cardiovascular Genetics, Vol. 6, No. 6, 2013, p. 579-587.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)

AU - Oksala, Niku

AU - Pärssinen, Jenita

AU - Seppälä, Ilkka

AU - Raitoharju, Emma

AU - Ivana, Kholova

AU - Hernesniemi, Jussi

AU - Lyytikäinen, Leo Pekka

AU - Levula, Mari

AU - Mäkelä, Kari Matti

AU - Sioris, Thanos

AU - Kähönen, Mika

AU - Laaksonen, Reijo

AU - Hytönen, Vesa

AU - Lehtimäki, Terho

PY - 2013

Y1 - 2013

N2 - Background-Macrophage (MF) infiltration and smooth muscle cell (SMC) proliferation are hallmarks of atherosclerosis and unstable plaques. Neuroimmune guidance cue 1 (netrin-1 [NTN1]) plays a critical role controlling MF trafficking and SMC activation. Characterization of expression of NTN1 and its receptors and their association with plaque stability in human(s) is lacking. Methods and Results-The expression of NTN1 and its receptors did not differ in either whole blood or circulating monocytes from patients with coronary artery disease (n=55) compared with healthy controls (n=45). However, NTN1 was downregulated (-2.9-fold: P

AB - Background-Macrophage (MF) infiltration and smooth muscle cell (SMC) proliferation are hallmarks of atherosclerosis and unstable plaques. Neuroimmune guidance cue 1 (netrin-1 [NTN1]) plays a critical role controlling MF trafficking and SMC activation. Characterization of expression of NTN1 and its receptors and their association with plaque stability in human(s) is lacking. Methods and Results-The expression of NTN1 and its receptors did not differ in either whole blood or circulating monocytes from patients with coronary artery disease (n=55) compared with healthy controls (n=45). However, NTN1 was downregulated (-2.9-fold: P

KW - Atherosclerosis

KW - Gene expression

KW - Immunohistochemistry

KW - Macrophages

KW - Myocytes

KW - Smooth muscle

KW - Whole genome association analysis

KW - Atherosclerosis

KW - Gene expression

KW - Immunohistochemistry

KW - Macrophages

KW - Myocytes

KW - Smooth muscle

KW - Whole genome association analysis

U2 - 10.1161/circgenetics.113.000141

DO - 10.1161/circgenetics.113.000141

M3 - Article

C2 - 24122613

AN - SCOPUS:84892423180

SN - 1942-325X

VL - 6

SP - 579

EP - 587

JO - Circulation: Cardiovascular Genetics

JF - Circulation: Cardiovascular Genetics

IS - 6

ER -

Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)

Abstract

Keywords

Publication forum classification

UN SDGs

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