Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)

Niku Oksala, Jenita Pärssinen, Ilkka Seppälä, Emma Raitoharju, Kholova Ivana, Jussi Hernesniemi, Leo Pekka Lyytikäinen, Mari Levula, Kari Matti Mäkelä, Thanos Sioris, Mika Kähönen, Reijo Laaksonen, Vesa Hytönen, Terho Lehtimäki

Research output: Contribution to journalArticleScientificpeer-review

33 Citations (Scopus)

Abstract

Background-Macrophage (MF) infiltration and smooth muscle cell (SMC) proliferation are hallmarks of atherosclerosis and unstable plaques. Neuroimmune guidance cue 1 (netrin-1 [NTN1]) plays a critical role controlling MF trafficking and SMC activation. Characterization of expression of NTN1 and its receptors and their association with plaque stability in human(s) is lacking. Methods and Results-The expression of NTN1 and its receptors did not differ in either whole blood or circulating monocytes from patients with coronary artery disease (n=55) compared with healthy controls (n=45). However, NTN1 was downregulated (-2.9-fold: P

Original languageEnglish
Pages (from-to)579-587
Number of pages9
JournalCirculation: Cardiovascular Genetics
Volume6
Issue number6
DOIs
Publication statusPublished - 2013
Publication typeA1 Journal article-refereed

Keywords

  • Atherosclerosis
  • Gene expression
  • Immunohistochemistry
  • Macrophages
  • Myocytes
  • Smooth muscle
  • Whole genome association analysis

Publication forum classification

  • Publication forum level 1

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