Association of opium use and tobacco smoking with α-, β-, and γ-human papillomavirus oral infection

Abbas Karimi, Elham Mohebbi, Sandrine Mckay-Chopin, Maryam Hadji, Hamideh Rashidian, Maryam Marzban, Ahmad Naghibzadeh-Tahami, Mahin Gholipour, Hadi Eslami, Farin Kamangar, Massimo Tommasino, Tarik Gheit, Kazem Zendehdel

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Head and neck squamous cell carcinomas (HNSCCs) are linked to tobacco smoking, opium use, and human papillomavirus (HPV) infection. However, little is known about the association of HPV infection with risk factors of HNSCCs, including opium and tobacco use. This cross-sectional analysis of a national multi-center case–control study in Iran included 498 HNSCC cases and 242 controls. We investigated the association of opium and tobacco use with α- (n = 21), β- (n = 46), and γ-HPV (n = 52) types in saliva samples using type-specific bead-based multiplex genotyping assays (TS-MPG). We found that α-HPV positivity was significantly associated with tobacco smoking (OR = 10.35; 95% CI = 1.15, 93; p =.03), but not with opium use (OR = 1.06; 95% CI = 0.41, 2.76; p =.89). Additionally, tobacco smoking correlated with an elevated risk of β-species 2 HPV infection (OR = 1.28; 95% CI = 1.04, 1.58; p =.020). Conversely, opium use showed a positive association with γ-species 12 HPV infection (OR = 5.67; 95% CI = 1.43, 22.44; p =.013). These findings indicate that tobacco and opium use may influence the risk of HPV infection in different ways depending on the HPV genus and species. Further studies are needed to replicate these findings in other populations.

Original languageEnglish
Pages (from-to)1544-1548
Number of pages5
JournalInternational Journal of Cancer
Volume155
Issue number9
Early online date2024
DOIs
Publication statusPublished - Sept 2024
Publication typeA1 Journal article-refereed

Keywords

  • human papillomavirus infection
  • opium use
  • saliva samples
  • tobacco smoking

Publication forum classification

  • Publication forum level 2

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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