Association of opium use and tobacco smoking with α-, β-, and γ-human papillomavirus oral infection

Abbas Karimi; Elham Mohebbi; Sandrine Mckay-Chopin; Maryam Hadji; Hamideh Rashidian; Maryam Marzban; Ahmad Naghibzadeh-Tahami; Mahin Gholipour; Hadi Eslami; Farin Kamangar; Massimo Tommasino; Tarik Gheit; Kazem Zendehdel

doi:10.1002/ijc.35086

Association of opium use and tobacco smoking with α-, β-, and γ-human papillomavirus oral infection

Abbas Karimi
, Elham Mohebbi
, Sandrine Mckay-Chopin
, Maryam Hadji
, Hamideh Rashidian
, Maryam Marzban
, Ahmad Naghibzadeh-Tahami
, Mahin Gholipour
, Hadi Eslami
, Farin Kamangar
, Massimo Tommasino
, Tarik Gheit^*
, Kazem Zendehdel^*

^*Corresponding author for this work

Health Sciences

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

Head and neck squamous cell carcinomas (HNSCCs) are linked to tobacco smoking, opium use, and human papillomavirus (HPV) infection. However, little is known about the association of HPV infection with risk factors of HNSCCs, including opium and tobacco use. This cross-sectional analysis of a national multi-center case–control study in Iran included 498 HNSCC cases and 242 controls. We investigated the association of opium and tobacco use with α- (n = 21), β- (n = 46), and γ-HPV (n = 52) types in saliva samples using type-specific bead-based multiplex genotyping assays (TS-MPG). We found that α-HPV positivity was significantly associated with tobacco smoking (OR = 10.35; 95% CI = 1.15, 93; p =.03), but not with opium use (OR = 1.06; 95% CI = 0.41, 2.76; p =.89). Additionally, tobacco smoking correlated with an elevated risk of β-species 2 HPV infection (OR = 1.28; 95% CI = 1.04, 1.58; p =.020). Conversely, opium use showed a positive association with γ-species 12 HPV infection (OR = 5.67; 95% CI = 1.43, 22.44; p =.013). These findings indicate that tobacco and opium use may influence the risk of HPV infection in different ways depending on the HPV genus and species. Further studies are needed to replicate these findings in other populations.

Original language	English
Pages (from-to)	1544-1548
Number of pages	5
Journal	International Journal of Cancer
Volume	155
Issue number	9
Early online date	2024
DOIs	https://doi.org/10.1002/ijc.35086
Publication status	Published - Sept 2024
Publication type	A1 Journal article-refereed

Funding

We would like to acknowledge the late Dr. Massimo Tommasino for his significant contributions to this work. Dr. Tommasino was a valued co\u2010author and his dedication to the project will always be remembered. Sadly, he passed away on December 18, 2022. We extend our heartfelt condolences to his family and colleagues. The authors would like to thank the International Agency for Research on Cancer, Lyon, France, and IROPICAN study team (Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran), and the Deputy for Research of Tabriz University of Medical Sciences, Iran for all their supports. This study was financially supported by the National Institute for Medical Research Development (NIMAD) under Grant No. 940045, Iran, and IARC.

Funders	Funder number
IARC
National Institute for Medical Research Development	940045

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

human papillomavirus infection
opium use
saliva samples
tobacco smoking

Publication forum classification

Publication forum level 2

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1002/ijc.35086

Cite this

Karimi, A., Mohebbi, E., Mckay-Chopin, S., Hadji, M., Rashidian, H., Marzban, M., Naghibzadeh-Tahami, A., Gholipour, M., Eslami, H., Kamangar, F., Tommasino, M., Gheit, T., & Zendehdel, K. (2024). Association of opium use and tobacco smoking with α-, β-, and γ-human papillomavirus oral infection. International Journal of Cancer, 155(9), 1544-1548. https://doi.org/10.1002/ijc.35086

@article{7b558dd1434e483f98ae6e43c919c91c,

title = "Association of opium use and tobacco smoking with α-, β-, and γ-human papillomavirus oral infection",

abstract = "Head and neck squamous cell carcinomas (HNSCCs) are linked to tobacco smoking, opium use, and human papillomavirus (HPV) infection. However, little is known about the association of HPV infection with risk factors of HNSCCs, including opium and tobacco use. This cross-sectional analysis of a national multi-center case–control study in Iran included 498 HNSCC cases and 242 controls. We investigated the association of opium and tobacco use with α- (n = 21), β- (n = 46), and γ-HPV (n = 52) types in saliva samples using type-specific bead-based multiplex genotyping assays (TS-MPG). We found that α-HPV positivity was significantly associated with tobacco smoking (OR = 10.35; 95\% CI = 1.15, 93; p =.03), but not with opium use (OR = 1.06; 95\% CI = 0.41, 2.76; p =.89). Additionally, tobacco smoking correlated with an elevated risk of β-species 2 HPV infection (OR = 1.28; 95\% CI = 1.04, 1.58; p =.020). Conversely, opium use showed a positive association with γ-species 12 HPV infection (OR = 5.67; 95\% CI = 1.43, 22.44; p =.013). These findings indicate that tobacco and opium use may influence the risk of HPV infection in different ways depending on the HPV genus and species. Further studies are needed to replicate these findings in other populations.",

keywords = "human papillomavirus infection, opium use, saliva samples, tobacco smoking",

author = "Abbas Karimi and Elham Mohebbi and Sandrine Mckay-Chopin and Maryam Hadji and Hamideh Rashidian and Maryam Marzban and Ahmad Naghibzadeh-Tahami and Mahin Gholipour and Hadi Eslami and Farin Kamangar and Massimo Tommasino and Tarik Gheit and Kazem Zendehdel",

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year = "2024",

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Karimi, A, Mohebbi, E, Mckay-Chopin, S, Hadji, M, Rashidian, H, Marzban, M, Naghibzadeh-Tahami, A, Gholipour, M, Eslami, H, Kamangar, F, Tommasino, M, Gheit, T & Zendehdel, K 2024, 'Association of opium use and tobacco smoking with α-, β-, and γ-human papillomavirus oral infection', International Journal of Cancer, vol. 155, no. 9, pp. 1544-1548. https://doi.org/10.1002/ijc.35086

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T1 - Association of opium use and tobacco smoking with α-, β-, and γ-human papillomavirus oral infection

AU - Karimi, Abbas

AU - Mohebbi, Elham

AU - Mckay-Chopin, Sandrine

AU - Hadji, Maryam

AU - Rashidian, Hamideh

AU - Marzban, Maryam

AU - Naghibzadeh-Tahami, Ahmad

AU - Gholipour, Mahin

AU - Eslami, Hadi

AU - Kamangar, Farin

AU - Tommasino, Massimo

AU - Gheit, Tarik

AU - Zendehdel, Kazem

PY - 2024/9

Y1 - 2024/9

N2 - Head and neck squamous cell carcinomas (HNSCCs) are linked to tobacco smoking, opium use, and human papillomavirus (HPV) infection. However, little is known about the association of HPV infection with risk factors of HNSCCs, including opium and tobacco use. This cross-sectional analysis of a national multi-center case–control study in Iran included 498 HNSCC cases and 242 controls. We investigated the association of opium and tobacco use with α- (n = 21), β- (n = 46), and γ-HPV (n = 52) types in saliva samples using type-specific bead-based multiplex genotyping assays (TS-MPG). We found that α-HPV positivity was significantly associated with tobacco smoking (OR = 10.35; 95% CI = 1.15, 93; p =.03), but not with opium use (OR = 1.06; 95% CI = 0.41, 2.76; p =.89). Additionally, tobacco smoking correlated with an elevated risk of β-species 2 HPV infection (OR = 1.28; 95% CI = 1.04, 1.58; p =.020). Conversely, opium use showed a positive association with γ-species 12 HPV infection (OR = 5.67; 95% CI = 1.43, 22.44; p =.013). These findings indicate that tobacco and opium use may influence the risk of HPV infection in different ways depending on the HPV genus and species. Further studies are needed to replicate these findings in other populations.

AB - Head and neck squamous cell carcinomas (HNSCCs) are linked to tobacco smoking, opium use, and human papillomavirus (HPV) infection. However, little is known about the association of HPV infection with risk factors of HNSCCs, including opium and tobacco use. This cross-sectional analysis of a national multi-center case–control study in Iran included 498 HNSCC cases and 242 controls. We investigated the association of opium and tobacco use with α- (n = 21), β- (n = 46), and γ-HPV (n = 52) types in saliva samples using type-specific bead-based multiplex genotyping assays (TS-MPG). We found that α-HPV positivity was significantly associated with tobacco smoking (OR = 10.35; 95% CI = 1.15, 93; p =.03), but not with opium use (OR = 1.06; 95% CI = 0.41, 2.76; p =.89). Additionally, tobacco smoking correlated with an elevated risk of β-species 2 HPV infection (OR = 1.28; 95% CI = 1.04, 1.58; p =.020). Conversely, opium use showed a positive association with γ-species 12 HPV infection (OR = 5.67; 95% CI = 1.43, 22.44; p =.013). These findings indicate that tobacco and opium use may influence the risk of HPV infection in different ways depending on the HPV genus and species. Further studies are needed to replicate these findings in other populations.

KW - human papillomavirus infection

KW - opium use

KW - saliva samples

KW - tobacco smoking

U2 - 10.1002/ijc.35086

DO - 10.1002/ijc.35086

M3 - Article

AN - SCOPUS:85199502345

SN - 0020-7136

VL - 155

SP - 1544

EP - 1548

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 9

ER -

Association of opium use and tobacco smoking with α-, β-, and γ-human papillomavirus oral infection

Abstract

Funding

UN SDGs

Keywords

Publication forum classification

ASJC Scopus subject areas

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