Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events

Kari Matti Mäkelä; Matthew Traylor; Niku Oksala; Marcus E. Kleber; Ilkka Seppälä; Leo Pekka Lyytikäinen; Jussi A. Hernesniemi; Mika Kähönen; Steve Bevan; Peter M. Rothwell; Cathie Sudlow; Martin Dichgans; Graciela Delgado; Tanja B. Grammer; Hubert Scharnagl; Hugh S. Markus; Winfried März; Terho Lehtimäki

doi:10.1016/j.atherosclerosis.2014.03.002

Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events

Kari Matti Mäkelä, Matthew Traylor, Niku Oksala, Marcus E. Kleber, Ilkka Seppälä, Leo Pekka Lyytikäinen, Jussi A. Hernesniemi, Mika Kähönen, Steve Bevan, Peter M. Rothwell, Cathie Sudlow, Martin Dichgans, Graciela Delgado, Tanja B. Grammer, Hubert Scharnagl, Hugh S. Markus, Winfried März, Terho Lehtimäki

Research output: Contribution to journal › Article › Scientific › peer-review

13 Citations (Scopus)

Abstract

Background and purpose: Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD). Methods: The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A: N=2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B: N=3548 cases, 5972 controls). Results: In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p=0.030: odds ratio=1.29 [95% confidence interval 1.03-1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke. Conclusions: The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.

Original language	English
Pages (from-to)	214-217
Number of pages	4
Journal	Atherosclerosis
Volume	234
Issue number	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2014.03.002
Publication status	Published - 2014
Publication type	A1 Journal article-refereed

Keywords

Genetics
Oxidized low-density lipoprotein
Single nucleotide polymorphism
Stroke
Transient ischaemic attack

Publication forum classification

Publication forum level 2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.atherosclerosis.2014.03.002

Cite this

Mäkelä, K. M., Traylor, M., Oksala, N., Kleber, M. E., Seppälä, I., Lyytikäinen, L. P., Hernesniemi, J. A., Kähönen, M., Bevan, S., Rothwell, P. M., Sudlow, C., Dichgans, M., Delgado, G., Grammer, T. B., Scharnagl, H., Markus, H. S., März, W., & Lehtimäki, T. (2014). Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events. Atherosclerosis, 234(1), 214-217. https://doi.org/10.1016/j.atherosclerosis.2014.03.002

@article{c8fb8f787e064668b3b690f9fdf2a247,

title = "Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events",

abstract = "Background and purpose: Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD). Methods: The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A: N=2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B: N=3548 cases, 5972 controls). Results: In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p=0.030: odds ratio=1.29 [95% confidence interval 1.03-1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke. Conclusions: The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.",

keywords = "Genetics, Oxidized low-density lipoprotein, Single nucleotide polymorphism, Stroke, Transient ischaemic attack, Genetics, Oxidized low-density lipoprotein, Single nucleotide polymorphism, Stroke, Transient ischaemic attack",

author = "M{\"a}kel{\"a}, {Kari Matti} and Matthew Traylor and Niku Oksala and Kleber, {Marcus E.} and Ilkka Sepp{\"a}l{\"a} and Lyytik{\"a}inen, {Leo Pekka} and Hernesniemi, {Jussi A.} and Mika K{\"a}h{\"o}nen and Steve Bevan and Rothwell, {Peter M.} and Cathie Sudlow and Martin Dichgans and Graciela Delgado and Grammer, {Tanja B.} and Hubert Scharnagl and Markus, {Hugh S.} and Winfried M{\"a}rz and Terho Lehtim{\"a}ki",

year = "2014",

doi = "10.1016/j.atherosclerosis.2014.03.002",

language = "English",

volume = "234",

pages = "214--217",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier",

number = "1",

}

Mäkelä, KM, Traylor, M, Oksala, N, Kleber, ME, Seppälä, I, Lyytikäinen, LP , Hernesniemi, JA , Kähönen, M, Bevan, S, Rothwell, PM, Sudlow, C, Dichgans, M, Delgado, G, Grammer, TB, Scharnagl, H, Markus, HS, März, W & Lehtimäki, T 2014, 'Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events', Atherosclerosis, vol. 234, no. 1, pp. 214-217. https://doi.org/10.1016/j.atherosclerosis.2014.03.002

TY - JOUR

T1 - Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events

AU - Mäkelä, Kari Matti

AU - Traylor, Matthew

AU - Oksala, Niku

AU - Kleber, Marcus E.

AU - Seppälä, Ilkka

AU - Lyytikäinen, Leo Pekka

AU - Hernesniemi, Jussi A.

AU - Kähönen, Mika

AU - Bevan, Steve

AU - Rothwell, Peter M.

AU - Sudlow, Cathie

AU - Dichgans, Martin

AU - Delgado, Graciela

AU - Grammer, Tanja B.

AU - Scharnagl, Hubert

AU - Markus, Hugh S.

AU - März, Winfried

AU - Lehtimäki, Terho

PY - 2014

Y1 - 2014

N2 - Background and purpose: Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD). Methods: The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A: N=2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B: N=3548 cases, 5972 controls). Results: In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p=0.030: odds ratio=1.29 [95% confidence interval 1.03-1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke. Conclusions: The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.

AB - Background and purpose: Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD). Methods: The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A: N=2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B: N=3548 cases, 5972 controls). Results: In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p=0.030: odds ratio=1.29 [95% confidence interval 1.03-1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke. Conclusions: The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.

KW - Genetics

KW - Oxidized low-density lipoprotein

KW - Single nucleotide polymorphism

KW - Stroke

KW - Transient ischaemic attack

KW - Genetics

KW - Oxidized low-density lipoprotein

KW - Single nucleotide polymorphism

KW - Stroke

KW - Transient ischaemic attack

U2 - 10.1016/j.atherosclerosis.2014.03.002

DO - 10.1016/j.atherosclerosis.2014.03.002

M3 - Article

AN - SCOPUS:84897947033

SN - 0021-9150

VL - 234

SP - 214

EP - 217

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events

Abstract

Keywords

Publication forum classification

UN SDGs

Access to Document

Fingerprint

Cite this