Abstract
BACKGROUND: DAVID is the most popular tool for interpreting large lists of gene/proteins classically produced in high-throughput experiments. However, the use of DAVID website becomes difficult when analyzing multiple gene lists, for it does not provide an adequate visualization tool to show/compare multiple enrichment results in a concise and informative manner.
RESULT: We implemented a new R-based graphical tool, BACA (Bubble chArt to Compare Annotations), which uses the DAVID web service for cross-comparing enrichment analysis results derived from multiple large gene lists. BACA is implemented in R and is freely available at the CRAN repository ( http://cran.r-project.org/web/packages/BACA/ ).
CONCLUSION: The package BACA allows R users to combine multiple annotation charts into one output graph by passing DAVID website.
| Original language | English |
|---|---|
| Pages (from-to) | 37 |
| Journal | BMC Bioinformatics |
| Volume | 16 |
| DOIs | |
| Publication status | Published - 5 Feb 2015 |
| Externally published | Yes |
| Publication type | A1 Journal article-refereed |
Keywords
- Computational Biology/methods
- Databases, Genetic
- Genes
- Molecular Sequence Annotation
- Proteins
- Software
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