Biology of childhood hepatoblastoma and the search for novel treatments

Marjut Pihlajoki; Katja Eloranta; Ruth Nousiainen; Ville Väyrynen; Tea Soini; Antti Kyrönlahti; Seppo Parkkila; Jukka Kanerva; David B. Wilson; Mikko P. Pakarinen; Markku Heikinheimo

doi:10.1016/j.jbior.2023.100997

Biology of childhood hepatoblastoma and the search for novel treatments

Marjut Pihlajoki, Katja Eloranta, Ruth Nousiainen, Ville Väyrynen, Tea Soini, Antti Kyrönlahti, Seppo Parkkila, Jukka Kanerva, David B. Wilson, Mikko P. Pakarinen, Markku Heikinheimo

Department of Clinical Chemistry

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Our research laboratory has a longstanding interest in developmental disorders and embryonic tumors, and recent efforts have focused on the pathogenesis of pediatric liver tumors. This review focuses on hepatoblastoma (HB), the most common pediatric liver malignancy. Despite advances in treatment, patients with metastatic HB have a poor prognosis, and survivors often have permanent side effects attributable to chemotherapy. In an effort to improve survival and lessen long-term complications of HB, we have searched for novel molecular vulnerabilities using a combination of patient derived cell lines, metabolomics, and RNA sequencing of human samples at diagnosis and follow-up. These studies have shed light on pathogenesis and identified putative targets for future therapies in children with advanced HB.

Original language	English
Article number	100997
Number of pages	13
Journal	ADVANCES IN BIOLOGICAL REGULATION
Volume	91
Early online date	Oct 2023
DOIs	https://doi.org/10.1016/j.jbior.2023.100997
Publication status	Published - Jan 2024
Publication type	A1 Journal article-refereed

Funding

This work was supported by Helsinki University Central Hospital Research Grants, Päivikki and Sakari Sohlberg Foundation, and Sigrid Jusélius Foundation.

Funders	Funder number
Helsingin ja Uudenmaan sairaanhoitopiiri
Päivikki ja Sakari Sohlbergin Säätiö
Sigrid Juséliuksen Säätiö

Keywords

Carbonic anhydrase IX
GATA4
Hepatoblastoma
Neuropilins
Ubiquitin conjugating enzyme E2 C

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jbior.2023.100997Licence: CC BY

1-s2.0-S221249262300043X-main-1Final published version, 3.17 MBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-2023120710503Licence: CC BY

Cite this

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title = "Biology of childhood hepatoblastoma and the search for novel treatments",

abstract = "Our research laboratory has a longstanding interest in developmental disorders and embryonic tumors, and recent efforts have focused on the pathogenesis of pediatric liver tumors. This review focuses on hepatoblastoma (HB), the most common pediatric liver malignancy. Despite advances in treatment, patients with metastatic HB have a poor prognosis, and survivors often have permanent side effects attributable to chemotherapy. In an effort to improve survival and lessen long-term complications of HB, we have searched for novel molecular vulnerabilities using a combination of patient derived cell lines, metabolomics, and RNA sequencing of human samples at diagnosis and follow-up. These studies have shed light on pathogenesis and identified putative targets for future therapies in children with advanced HB.",

keywords = "Carbonic anhydrase IX, GATA4, Hepatoblastoma, Neuropilins, Ubiquitin conjugating enzyme E2 C",

author = "Marjut Pihlajoki and Katja Eloranta and Ruth Nousiainen and Ville V{\"a}yrynen and Tea Soini and Antti Kyr{\"o}nlahti and Seppo Parkkila and Jukka Kanerva and Wilson, {David B.} and Pakarinen, {Mikko P.} and Markku Heikinheimo",

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doi = "10.1016/j.jbior.2023.100997",

language = "English",

volume = "91",

journal = "ADVANCES IN BIOLOGICAL REGULATION",

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T1 - Biology of childhood hepatoblastoma and the search for novel treatments

AU - Pihlajoki, Marjut

AU - Eloranta, Katja

AU - Nousiainen, Ruth

AU - Väyrynen, Ville

AU - Soini, Tea

AU - Kyrönlahti, Antti

AU - Parkkila, Seppo

AU - Kanerva, Jukka

AU - Wilson, David B.

AU - Pakarinen, Mikko P.

AU - Heikinheimo, Markku

PY - 2024/1

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N2 - Our research laboratory has a longstanding interest in developmental disorders and embryonic tumors, and recent efforts have focused on the pathogenesis of pediatric liver tumors. This review focuses on hepatoblastoma (HB), the most common pediatric liver malignancy. Despite advances in treatment, patients with metastatic HB have a poor prognosis, and survivors often have permanent side effects attributable to chemotherapy. In an effort to improve survival and lessen long-term complications of HB, we have searched for novel molecular vulnerabilities using a combination of patient derived cell lines, metabolomics, and RNA sequencing of human samples at diagnosis and follow-up. These studies have shed light on pathogenesis and identified putative targets for future therapies in children with advanced HB.

AB - Our research laboratory has a longstanding interest in developmental disorders and embryonic tumors, and recent efforts have focused on the pathogenesis of pediatric liver tumors. This review focuses on hepatoblastoma (HB), the most common pediatric liver malignancy. Despite advances in treatment, patients with metastatic HB have a poor prognosis, and survivors often have permanent side effects attributable to chemotherapy. In an effort to improve survival and lessen long-term complications of HB, we have searched for novel molecular vulnerabilities using a combination of patient derived cell lines, metabolomics, and RNA sequencing of human samples at diagnosis and follow-up. These studies have shed light on pathogenesis and identified putative targets for future therapies in children with advanced HB.

KW - Carbonic anhydrase IX

KW - GATA4

KW - Hepatoblastoma

KW - Neuropilins

KW - Ubiquitin conjugating enzyme E2 C

U2 - 10.1016/j.jbior.2023.100997

DO - 10.1016/j.jbior.2023.100997

M3 - Article

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JO - ADVANCES IN BIOLOGICAL REGULATION

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ER -

Biology of childhood hepatoblastoma and the search for novel treatments

Abstract

Funding

Keywords

Publication forum classification

ASJC Scopus subject areas

UN SDGs

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