Building blocks of microphysiological system to model physiology and pathophysiology of human heart

Hanna Vuorenpää; Miina Björninen; Hannu Välimäki; Antti Ahola; Mart Kroon; Laura Honkamäki; Jussi T. Koivumäki; Mari Pekkanen-Mattila

doi:10.3389/fphys.2023.1213959

Building blocks of microphysiological system to model physiology and pathophysiology of human heart

Hanna Vuorenpää
, Miina Björninen
, Hannu Välimäki
, Antti Ahola
, Mart Kroon
, Laura Honkamäki
, Jussi T. Koivumäki
, Mari Pekkanen-Mattila^*

^*Corresponding author for this work

RDI

Research output: Contribution to journal › Review Article › peer-review

20 Citations (Scopus)

52 Downloads (Pure)

Abstract

Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology. MPS offer an advanced in vitro platform that can be used to study human organ and tissue level functions in health and in diseased states more accurately than traditional single cell cultures or even animal models. Key features in MPS include microenvironmental control and monitoring as well as high biological complexity of the target tissue. To reach these qualities, cross-disciplinary collaboration from multiple fields of science is required to build MPS. Here, we review different areas of expertise and describe essential building blocks of heart MPS including relevant cardiac cell types, supporting matrix, mechanical stimulation, functional measurements, and computational modelling. The review presents current methods in cardiac MPS and provides insights for future MPS development with improved recapitulation of human physiology.

Original language	English
Article number	1213959
Number of pages	28
Journal	Frontiers in Physiology
Volume	14
DOIs	https://doi.org/10.3389/fphys.2023.1213959
Publication status	Published - 2023
Publication type	A2 Review article in a scientific journal

Funding

The financial support from Academy of Finland for the Centre of Excellence in Body-on-Chip Research (353175, 353178, 353174, 353173, 353177, 353176), Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital, Finnish Cultural Foundation and Finnish Foundation for Cardiovascular Research (190088) are gratefully acknowledged.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

biomaterials
cardiac modeling
co-cultures
environmental control
imaging
in silico
in vitro
microphysiological systems

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Physiology
Physiology (medical)

Access to Document

10.3389/fphys.2023.1213959Licence: CC BY

fphys-14-1213959Final published version, 2.6 MBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202309088058Licence: CC BY

Cite this

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title = "Building blocks of microphysiological system to model physiology and pathophysiology of human heart",

abstract = "Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology. MPS offer an advanced in vitro platform that can be used to study human organ and tissue level functions in health and in diseased states more accurately than traditional single cell cultures or even animal models. Key features in MPS include microenvironmental control and monitoring as well as high biological complexity of the target tissue. To reach these qualities, cross-disciplinary collaboration from multiple fields of science is required to build MPS. Here, we review different areas of expertise and describe essential building blocks of heart MPS including relevant cardiac cell types, supporting matrix, mechanical stimulation, functional measurements, and computational modelling. The review presents current methods in cardiac MPS and provides insights for future MPS development with improved recapitulation of human physiology.",

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author = "Hanna Vuorenp{\"a}{\"a} and Miina Bj{\"o}rninen and Hannu V{\"a}lim{\"a}ki and Antti Ahola and Mart Kroon and Laura Honkam{\"a}ki and Koivum{\"a}ki, \{Jussi T.\} and Mari Pekkanen-Mattila",

note = "Funding Information: The financial support from Academy of Finland for the Centre of Excellence in Body-on-Chip Research (353175, 353178, 353174, 353173, 353177, 353176), Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital, Finnish Cultural Foundation and Finnish Foundation for Cardiovascular Research (190088) are gratefully acknowledged. Publisher Copyright: Copyright {\textcopyright} 2023 Vuorenp{\"a}{\"a}, Bj{\"o}rninen, V{\"a}lim{\"a}ki, Ahola, Kroon, Honkam{\"a}ki, Koivum{\"a}ki and Pekkanen-Mattila.",

year = "2023",

doi = "10.3389/fphys.2023.1213959",

language = "English",

volume = "14",

journal = "Frontiers in Physiology",

issn = "1664-042X",

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T1 - Building blocks of microphysiological system to model physiology and pathophysiology of human heart

AU - Vuorenpää, Hanna

AU - Björninen, Miina

AU - Välimäki, Hannu

AU - Ahola, Antti

AU - Kroon, Mart

AU - Honkamäki, Laura

AU - Koivumäki, Jussi T.

AU - Pekkanen-Mattila, Mari

N1 - Funding Information: The financial support from Academy of Finland for the Centre of Excellence in Body-on-Chip Research (353175, 353178, 353174, 353173, 353177, 353176), Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital, Finnish Cultural Foundation and Finnish Foundation for Cardiovascular Research (190088) are gratefully acknowledged. Publisher Copyright: Copyright © 2023 Vuorenpää, Björninen, Välimäki, Ahola, Kroon, Honkamäki, Koivumäki and Pekkanen-Mattila.

PY - 2023

Y1 - 2023

N2 - Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology. MPS offer an advanced in vitro platform that can be used to study human organ and tissue level functions in health and in diseased states more accurately than traditional single cell cultures or even animal models. Key features in MPS include microenvironmental control and monitoring as well as high biological complexity of the target tissue. To reach these qualities, cross-disciplinary collaboration from multiple fields of science is required to build MPS. Here, we review different areas of expertise and describe essential building blocks of heart MPS including relevant cardiac cell types, supporting matrix, mechanical stimulation, functional measurements, and computational modelling. The review presents current methods in cardiac MPS and provides insights for future MPS development with improved recapitulation of human physiology.

AB - Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology. MPS offer an advanced in vitro platform that can be used to study human organ and tissue level functions in health and in diseased states more accurately than traditional single cell cultures or even animal models. Key features in MPS include microenvironmental control and monitoring as well as high biological complexity of the target tissue. To reach these qualities, cross-disciplinary collaboration from multiple fields of science is required to build MPS. Here, we review different areas of expertise and describe essential building blocks of heart MPS including relevant cardiac cell types, supporting matrix, mechanical stimulation, functional measurements, and computational modelling. The review presents current methods in cardiac MPS and provides insights for future MPS development with improved recapitulation of human physiology.

KW - biomaterials

KW - cardiac modeling

KW - co-cultures

KW - environmental control

KW - imaging

KW - in silico

KW - in vitro

KW - microphysiological systems

U2 - 10.3389/fphys.2023.1213959

DO - 10.3389/fphys.2023.1213959

M3 - Review Article

AN - SCOPUS:85165170141

SN - 1664-042X

VL - 14

JO - Frontiers in Physiology

JF - Frontiers in Physiology

M1 - 1213959

ER -

Building blocks of microphysiological system to model physiology and pathophysiology of human heart

Abstract

Funding

UN SDGs

Keywords

Publication forum classification

ASJC Scopus subject areas

Access to Document

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Cite this