Abstract
Metabolic syndrome (MetS) is a cluster of risk factors of cardiovascular disease (CVD). CVD is the leading cause of death globally and it causes more than four million deaths every year. The goal of treating MetS is to reduce the risk of CVD by controlling the associated risk factors with lifestyle changes and pharmacological treatment.
The aim of this study was to investigate how CVD risk factors among Finnish men with MetS respond to different dietary fat consumption, how the risk factors are associated with different levels of physical activity and the incidence of CVD during long-term follow-up.
Our study subjects were 120 men with MetS according to NCEP-ATP III criteria and 80 physically active non-MetS men aged from 30 to 65 years. We compared the effects of cold-pressed turnip rapeseed oil (CPTRO) and butter in a dietary intervention. The association between physical activity and CVD risk factors was investigated in a cross-sectional study comparing men with and without MetS. We conducted a 15-year follow-up study regarding CVD outcomes among 105 men with MetS.
CPTRO improved insulin sensitivity compared to butter. Men with MetS and engaging in a lot of daily physical activity had higher resting heart rate, high-sensitive C-reactive protein (hs-CRP) and triglycerides and lower high-density lipoprotein than non-MetS subjects only taking a moderate amount of daily physical activity. Subjects with MetS and high hs-CRP had a higher risk for CVD and all-cause mortality during 15-year follow-up than those with low hs-CRP. Subjects with normal large artery elasticity had fever adverse outcomes than those with impaired large artery elasticity.
Choosing CPTRO over butter seems to be beneficial for men with MetS. Lifestyle treatment of MetS with physical activity alone is an insufficient strategy. Our MetS subjects experienced fewer CVD endpoints than expected but those with low-grade inflammation or abnormal large artery elasticity were at higher risk.
The aim of this study was to investigate how CVD risk factors among Finnish men with MetS respond to different dietary fat consumption, how the risk factors are associated with different levels of physical activity and the incidence of CVD during long-term follow-up.
Our study subjects were 120 men with MetS according to NCEP-ATP III criteria and 80 physically active non-MetS men aged from 30 to 65 years. We compared the effects of cold-pressed turnip rapeseed oil (CPTRO) and butter in a dietary intervention. The association between physical activity and CVD risk factors was investigated in a cross-sectional study comparing men with and without MetS. We conducted a 15-year follow-up study regarding CVD outcomes among 105 men with MetS.
CPTRO improved insulin sensitivity compared to butter. Men with MetS and engaging in a lot of daily physical activity had higher resting heart rate, high-sensitive C-reactive protein (hs-CRP) and triglycerides and lower high-density lipoprotein than non-MetS subjects only taking a moderate amount of daily physical activity. Subjects with MetS and high hs-CRP had a higher risk for CVD and all-cause mortality during 15-year follow-up than those with low hs-CRP. Subjects with normal large artery elasticity had fever adverse outcomes than those with impaired large artery elasticity.
Choosing CPTRO over butter seems to be beneficial for men with MetS. Lifestyle treatment of MetS with physical activity alone is an insufficient strategy. Our MetS subjects experienced fewer CVD endpoints than expected but those with low-grade inflammation or abnormal large artery elasticity were at higher risk.
| Original language | English |
|---|---|
| Place of Publication | Tampere |
| Publisher | Tampere University |
| ISBN (Electronic) | 978-952-03-3722-3 |
| ISBN (Print) | 978-952-03-3721-6 |
| Publication status | Published - 2025 |
| Publication type | G5 Doctoral dissertation (articles) |
Publication series
| Name | Tampere University Dissertations - Tampereen yliopiston väitöskirjat |
|---|---|
| Volume | 1147 |
| ISSN (Print) | 2489-9860 |
| ISSN (Electronic) | 2490-0028 |
