Carotid artery longitudinal wall motion alterations associated with metabolic syndrome and insulin resistance

S. Helena Taivainen, Tiina M. Laitinen, Heikki Yli-Ollila, Markus Juonala, Mika Kähönen, Olli T. Raitakari, Tomi P. Laitinen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background and aims: Our objective was to study relationships between the new biomarker of vascular health, carotid artery longitudinal wall motion (CALM) and metabolic syndrome (MetS). Methods: Carotid ultrasound and assessment of MetS and its components were performed with 281 subjects aged 30–45 years. In the longitudinal motion analysis, the amplitude of motion and the antegrade-oriented and retrograde-oriented components of motion between the intima–media complex and adventitial layer of the common carotid artery wall were assessed. Results: Metabolic syndrome, according to the harmonized criteria, was detected in 53 subjects (19%). MetS was significantly associated with increased antegrade and decreased retrograde longitudinal motion in the carotid artery wall. Augmented antegrade amplitude of longitudinal motion was associated with obesity (β = 0.149, p <.05) and low HDL cholesterol (β = 0.177, p <.01). Attenuated retrograde amplitude of longitudinal motion was associated with hypertension (β = −0.156, p <.05), obesity (β = −0.138, p <.05) and hyperinsulinaemia (β = −0.158, p <.01). Moreover, insulin resistance (homeostasis model assessment index above 2.44) was associated with adverse changes in CALM. Conclusion: Metabolic syndrome and insulin resistance were associated with alterations in CALM. In particular, hypertension, obesity and hyperinsulinaemia were associated with reduced total peak-to-peak amplitude as well as increased antegrade and reduced retrograde amplitudes, all of which might be markers of unfavourable vascular health.

Original languageEnglish
Pages (from-to)199-207
JournalClinical Physiology and Functional Imaging
Volume41
Issue number2
Early online date19 Dec 2020
DOIs
Publication statusPublished - 2021
Publication typeA1 Journal article-refereed

Keywords

  • arterial stiffness
  • cardiovascular risk factors
  • hyperinsulinaemia
  • hypertension
  • insulin resistance
  • motion tracking
  • ultrasound imaging

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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