Carotid artery longitudinal wall motion alterations associated with metabolic syndrome and insulin resistance

S. Helena Taivainen; Tiina M. Laitinen; Heikki Yli-Ollila; Markus Juonala; Mika Kähönen; Olli T. Raitakari; Tomi P. Laitinen

doi:10.1111/cpf.12687

Carotid artery longitudinal wall motion alterations associated with metabolic syndrome and insulin resistance

S. Helena Taivainen^*
, Tiina M. Laitinen
, Heikki Yli-Ollila
, Markus Juonala
, Mika Kähönen
, Olli T. Raitakari
, Tomi P. Laitinen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

6 Citations (Scopus)

Abstract

Background and aims: Our objective was to study relationships between the new biomarker of vascular health, carotid artery longitudinal wall motion (CALM) and metabolic syndrome (MetS). Methods: Carotid ultrasound and assessment of MetS and its components were performed with 281 subjects aged 30–45 years. In the longitudinal motion analysis, the amplitude of motion and the antegrade-oriented and retrograde-oriented components of motion between the intima–media complex and adventitial layer of the common carotid artery wall were assessed. Results: Metabolic syndrome, according to the harmonized criteria, was detected in 53 subjects (19%). MetS was significantly associated with increased antegrade and decreased retrograde longitudinal motion in the carotid artery wall. Augmented antegrade amplitude of longitudinal motion was associated with obesity (β = 0.149, p <.05) and low HDL cholesterol (β = 0.177, p <.01). Attenuated retrograde amplitude of longitudinal motion was associated with hypertension (β = −0.156, p <.05), obesity (β = −0.138, p <.05) and hyperinsulinaemia (β = −0.158, p <.01). Moreover, insulin resistance (homeostasis model assessment index above 2.44) was associated with adverse changes in CALM. Conclusion: Metabolic syndrome and insulin resistance were associated with alterations in CALM. In particular, hypertension, obesity and hyperinsulinaemia were associated with reduced total peak-to-peak amplitude as well as increased antegrade and reduced retrograde amplitudes, all of which might be markers of unfavourable vascular health.

Original language	English
Pages (from-to)	199-207
Journal	Clinical Physiology and Functional Imaging
Volume	41
Issue number	2
Early online date	19 Dec 2020
DOIs	https://doi.org/10.1111/cpf.12687
Publication status	Published - 2021
Publication type	A1 Journal article-refereed

Funding

We acknowledge the financial support of the specified government transfers to Kuopio University Hospital, the Finnish Cultural Foundation of North Savo, Ida Montins Foundation, Kuopio University Foundation, Antti ja Tyyne Soininen Foundation, Finnish Medical Foundation, Orion Research Foundation, Aarne Koskelo Foundation and Yrjö Jahnsson Foundation. The Young Finns Study has been financially supported by the Academy of Finland: grants 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi), the Social Insurance Institution of Finland, Kuopio, Tampere and Turku University Hospital Medical Funds, Juho Vainio Foundation, Sigrid Jusèlius Foundation, Yrjö Jahnsson Foundation, Paavo Nurmi Foundation, Finnish Foundation for Cardiovascular Research and Finnish Cultural Foundation, Tampere Tuberculosis Foundation and Emil Aaltonen Foundation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

arterial stiffness
cardiovascular risk factors
hyperinsulinaemia
hypertension
insulin resistance
motion tracking
ultrasound imaging

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Physiology
Physiology (medical)

Access to Document

10.1111/cpf.12687

https://erepo.uef.fi/handle/123456789/24448

Cite this

@article{d194c4fecd3943ec8cb60bca6cf46ba6,

title = "Carotid artery longitudinal wall motion alterations associated with metabolic syndrome and insulin resistance",

abstract = "Background and aims: Our objective was to study relationships between the new biomarker of vascular health, carotid artery longitudinal wall motion (CALM) and metabolic syndrome (MetS). Methods: Carotid ultrasound and assessment of MetS and its components were performed with 281 subjects aged 30–45 years. In the longitudinal motion analysis, the amplitude of motion and the antegrade-oriented and retrograde-oriented components of motion between the intima–media complex and adventitial layer of the common carotid artery wall were assessed. Results: Metabolic syndrome, according to the harmonized criteria, was detected in 53 subjects (19\%). MetS was significantly associated with increased antegrade and decreased retrograde longitudinal motion in the carotid artery wall. Augmented antegrade amplitude of longitudinal motion was associated with obesity (β = 0.149, p <.05) and low HDL cholesterol (β = 0.177, p <.01). Attenuated retrograde amplitude of longitudinal motion was associated with hypertension (β = −0.156, p <.05), obesity (β = −0.138, p <.05) and hyperinsulinaemia (β = −0.158, p <.01). Moreover, insulin resistance (homeostasis model assessment index above 2.44) was associated with adverse changes in CALM. Conclusion: Metabolic syndrome and insulin resistance were associated with alterations in CALM. In particular, hypertension, obesity and hyperinsulinaemia were associated with reduced total peak-to-peak amplitude as well as increased antegrade and reduced retrograde amplitudes, all of which might be markers of unfavourable vascular health.",

keywords = "arterial stiffness, cardiovascular risk factors, hyperinsulinaemia, hypertension, insulin resistance, motion tracking, ultrasound imaging",

author = "Taivainen, \{S. Helena\} and Laitinen, \{Tiina M.\} and Heikki Yli-Ollila and Markus Juonala and Mika K{\"a}h{\"o}nen and Raitakari, \{Olli T.\} and Laitinen, \{Tomi P.\}",

note = "Funding Information: We acknowledge the financial support of the specified government transfers to Kuopio University Hospital, the Finnish Cultural Foundation of North Savo, Ida Montins Foundation, Kuopio University Foundation, Antti ja Tyyne Soininen Foundation, Finnish Medical Foundation, Orion Research Foundation, Aarne Koskelo Foundation and Yrj{\"o} Jahnsson Foundation. The Young Finns Study has been financially supported by the Academy of Finland: grants 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi), the Social Insurance Institution of Finland, Kuopio, Tampere and Turku University Hospital Medical Funds, Juho Vainio Foundation, Sigrid Jus{\`e}lius Foundation, Yrj{\"o} Jahnsson Foundation, Paavo Nurmi Foundation, Finnish Foundation for Cardiovascular Research and Finnish Cultural Foundation, Tampere Tuberculosis Foundation and Emil Aaltonen Foundation Publisher Copyright: {\textcopyright} 2020 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley \& Sons Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

doi = "10.1111/cpf.12687",

language = "English",

volume = "41",

pages = "199--207",

journal = "Clinical Physiology and Functional Imaging",

issn = "1475-0961",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Carotid artery longitudinal wall motion alterations associated with metabolic syndrome and insulin resistance

AU - Taivainen, S. Helena

AU - Laitinen, Tiina M.

AU - Yli-Ollila, Heikki

AU - Juonala, Markus

AU - Kähönen, Mika

AU - Raitakari, Olli T.

AU - Laitinen, Tomi P.

N1 - Funding Information: We acknowledge the financial support of the specified government transfers to Kuopio University Hospital, the Finnish Cultural Foundation of North Savo, Ida Montins Foundation, Kuopio University Foundation, Antti ja Tyyne Soininen Foundation, Finnish Medical Foundation, Orion Research Foundation, Aarne Koskelo Foundation and Yrjö Jahnsson Foundation. The Young Finns Study has been financially supported by the Academy of Finland: grants 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi), the Social Insurance Institution of Finland, Kuopio, Tampere and Turku University Hospital Medical Funds, Juho Vainio Foundation, Sigrid Jusèlius Foundation, Yrjö Jahnsson Foundation, Paavo Nurmi Foundation, Finnish Foundation for Cardiovascular Research and Finnish Cultural Foundation, Tampere Tuberculosis Foundation and Emil Aaltonen Foundation Publisher Copyright: © 2020 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - Background and aims: Our objective was to study relationships between the new biomarker of vascular health, carotid artery longitudinal wall motion (CALM) and metabolic syndrome (MetS). Methods: Carotid ultrasound and assessment of MetS and its components were performed with 281 subjects aged 30–45 years. In the longitudinal motion analysis, the amplitude of motion and the antegrade-oriented and retrograde-oriented components of motion between the intima–media complex and adventitial layer of the common carotid artery wall were assessed. Results: Metabolic syndrome, according to the harmonized criteria, was detected in 53 subjects (19%). MetS was significantly associated with increased antegrade and decreased retrograde longitudinal motion in the carotid artery wall. Augmented antegrade amplitude of longitudinal motion was associated with obesity (β = 0.149, p <.05) and low HDL cholesterol (β = 0.177, p <.01). Attenuated retrograde amplitude of longitudinal motion was associated with hypertension (β = −0.156, p <.05), obesity (β = −0.138, p <.05) and hyperinsulinaemia (β = −0.158, p <.01). Moreover, insulin resistance (homeostasis model assessment index above 2.44) was associated with adverse changes in CALM. Conclusion: Metabolic syndrome and insulin resistance were associated with alterations in CALM. In particular, hypertension, obesity and hyperinsulinaemia were associated with reduced total peak-to-peak amplitude as well as increased antegrade and reduced retrograde amplitudes, all of which might be markers of unfavourable vascular health.

AB - Background and aims: Our objective was to study relationships between the new biomarker of vascular health, carotid artery longitudinal wall motion (CALM) and metabolic syndrome (MetS). Methods: Carotid ultrasound and assessment of MetS and its components were performed with 281 subjects aged 30–45 years. In the longitudinal motion analysis, the amplitude of motion and the antegrade-oriented and retrograde-oriented components of motion between the intima–media complex and adventitial layer of the common carotid artery wall were assessed. Results: Metabolic syndrome, according to the harmonized criteria, was detected in 53 subjects (19%). MetS was significantly associated with increased antegrade and decreased retrograde longitudinal motion in the carotid artery wall. Augmented antegrade amplitude of longitudinal motion was associated with obesity (β = 0.149, p <.05) and low HDL cholesterol (β = 0.177, p <.01). Attenuated retrograde amplitude of longitudinal motion was associated with hypertension (β = −0.156, p <.05), obesity (β = −0.138, p <.05) and hyperinsulinaemia (β = −0.158, p <.01). Moreover, insulin resistance (homeostasis model assessment index above 2.44) was associated with adverse changes in CALM. Conclusion: Metabolic syndrome and insulin resistance were associated with alterations in CALM. In particular, hypertension, obesity and hyperinsulinaemia were associated with reduced total peak-to-peak amplitude as well as increased antegrade and reduced retrograde amplitudes, all of which might be markers of unfavourable vascular health.

KW - arterial stiffness

KW - cardiovascular risk factors

KW - hyperinsulinaemia

KW - hypertension

KW - insulin resistance

KW - motion tracking

KW - ultrasound imaging

U2 - 10.1111/cpf.12687

DO - 10.1111/cpf.12687

M3 - Article

C2 - 33340230

AN - SCOPUS:85099017512

SN - 1475-0961

VL - 41

SP - 199

EP - 207

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

IS - 2

ER -

Carotid artery longitudinal wall motion alterations associated with metabolic syndrome and insulin resistance

Abstract

Funding

UN SDGs

Keywords

Publication forum classification

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this