Celiac disease and Sjögren's syndrome: A case report and review of literature

Daniel Vasile Balaban, Ancuta Mihai, Alina Dima, Alina Popp, Mariana Jinga, Ciprian Jurcut

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    BACKGROUND Celiac disease (CD) is a systemic, chronic immune-mediated disease triggered by gluten ingestion in genetically-susceptible individuals, with a prevalence of 1% worldwide. Sjogren's syndrome (SS) is also a systemic autoimmune disease, mainly characterized by ocular and oral sicca symptoms and signs. Sharing a common genetic background, CD and SS are known associated autoimmune diseases, but currently available guidelines are not reporting it. CASE SUMMARY We report the case of a 39-year-old woman, who was in the care of her rheumatologist for 2 years with SS. On routine follow-up she was found to have iron deficiency, without anemia. She had no gastrointestinal complaints and denied any obvious source of blood loss. IgA tissue transglutaminase antibodies were positive and endoscopy with duodenal biopsies revealed crypt hyperplasia and villous atrophy. A diagnosis of CD was set and gluten-free diet was recommended. CONCLUSION We present a review of existing data in the literature regarding the association of the two diseases, summarizing prevalence studies of CD in SS patients and the other way around. Screening recommendations and future research perspectives are also discussed, highlighting clinically relevant unanswered questions with respect to the association of CD with SS.

    Original languageEnglish
    Pages (from-to)4151-4161
    Number of pages11
    JournalWorld Journal of Clinical Cases
    Issue number18
    Publication statusPublished - 26 Sept 2020
    Publication typeA1 Journal article-refereed


    • Antibodies
    • Autoimmunity
    • Case report
    • Celiac disease
    • Prevalence
    • Screening
    • Sjögren syndrome

    Publication forum classification

    • Publication forum level 0

    ASJC Scopus subject areas

    • General Medicine


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