Celiac disease and Sjögren's syndrome: A case report and review of literature

Daniel Vasile Balaban, Ancuta Mihai, Alina Dima, Alina Popp, Mariana Jinga, Ciprian Jurcut

Research output: Contribution to journalArticleScientificpeer-review


BACKGROUND Celiac disease (CD) is a systemic, chronic immune-mediated disease triggered by gluten ingestion in genetically-susceptible individuals, with a prevalence of 1% worldwide. Sjogren's syndrome (SS) is also a systemic autoimmune disease, mainly characterized by ocular and oral sicca symptoms and signs. Sharing a common genetic background, CD and SS are known associated autoimmune diseases, but currently available guidelines are not reporting it. CASE SUMMARY We report the case of a 39-year-old woman, who was in the care of her rheumatologist for 2 years with SS. On routine follow-up she was found to have iron deficiency, without anemia. She had no gastrointestinal complaints and denied any obvious source of blood loss. IgA tissue transglutaminase antibodies were positive and endoscopy with duodenal biopsies revealed crypt hyperplasia and villous atrophy. A diagnosis of CD was set and gluten-free diet was recommended. CONCLUSION We present a review of existing data in the literature regarding the association of the two diseases, summarizing prevalence studies of CD in SS patients and the other way around. Screening recommendations and future research perspectives are also discussed, highlighting clinically relevant unanswered questions with respect to the association of CD with SS.

Original languageEnglish
Pages (from-to)4151-4161
Number of pages11
JournalWorld Journal of Clinical Cases
Issue number18
Publication statusPublished - 26 Sep 2020
Publication typeA1 Journal article-refereed


  • Antibodies
  • Autoimmunity
  • Case report
  • Celiac disease
  • Prevalence
  • Screening
  • Sjögren syndrome

Publication forum classification

  • Publication forum level 0

ASJC Scopus subject areas

  • Medicine(all)


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