Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan

Joachim Johansen; Koji Atarashi; Yasumichi Arai; Nobuyoshi Hirose; Søren J. Sørensen; Tommi Vatanen; Mikael Knip; Kenya Honda; Ramnik J. Xavier; Simon Rasmussen; Damian R. Plichta

doi:10.1038/s41564-023-01370-6

Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan

Joachim Johansen
, Koji Atarashi
, Yasumichi Arai
, Nobuyoshi Hirose
, Søren J. Sørensen
, Tommi Vatanen
, Mikael Knip
, Kenya Honda
, Ramnik J. Xavier^*
, Simon Rasmussen^*
, Damian R. Plichta^*

^*Corresponding author for this work

LAST, Paediatrics

Research output: Contribution to journal › Article › Scientific › peer-review

87 Citations (Scopus)

Original language	English
Pages (from-to)	1064-1078
Number of pages	15
Journal	Nature Microbiology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1038/s41564-023-01370-6
Publication status	Published - May 2023
Publication type	A1 Journal article-refereed

Funding

The study was funded in part by the Novo Nordisk Foundation (NNF21SA0072102); the Center for Microbiome Informatics and Therapeutics (R.J.X.); NIH grant DK043351 (R.J.X.); and NIH grant DK120485 (R.J.X.). J.J. and S.R. were supported by the Novo Nordisk Foundation (grant NNF14CC0001). K.H., K.A. and Y.A. were supported by Moonshot Research and Development Program (JP22zf0127007) and NeDDTrim (JP21ae0121041) from AMED Japan. K.H. and K.A. were supported by MEXT Japan World Premier International Research Center Initiative (WPI). The EDIA study was supported by NIH grant 1DP3DK094338-01 (M.K.) and by the Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research No. 250114 (M.K.).

Publication forum classification

Publication forum level 3

ASJC Scopus subject areas

Microbiology
Immunology
Applied Microbiology and Biotechnology
Genetics
Microbiology (medical)
Cell Biology

Access to Document

10.1038/s41564-023-01370-6

Cite this

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title = "Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan",

author = "Joachim Johansen and Koji Atarashi and Yasumichi Arai and Nobuyoshi Hirose and S{\o}rensen, \{S{\o}ren J.\} and Tommi Vatanen and Mikael Knip and Kenya Honda and Xavier, \{Ramnik J.\} and Simon Rasmussen and Plichta, \{Damian R.\}",

note = "Funding Information: The study was funded in part by the Novo Nordisk Foundation (NNF21SA0072102); the Center for Microbiome Informatics and Therapeutics (R.J.X.); NIH grant DK043351 (R.J.X.); and NIH grant DK120485 (R.J.X.). J.J. and S.R. were supported by the Novo Nordisk Foundation (grant NNF14CC0001). K.H., K.A. and Y.A. were supported by Moonshot Research and Development Program (JP22zf0127007) and NeDDTrim (JP21ae0121041) from AMED Japan. K.H. and K.A. were supported by MEXT Japan World Premier International Research Center Initiative (WPI). The EDIA study was supported by NIH grant 1DP3DK094338-01 (M.K.) and by the Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research No. 250114 (M.K.). Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature Limited.",

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doi = "10.1038/s41564-023-01370-6",

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T1 - Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan

AU - Johansen, Joachim

AU - Atarashi, Koji

AU - Arai, Yasumichi

AU - Hirose, Nobuyoshi

AU - Sørensen, Søren J.

AU - Vatanen, Tommi

AU - Knip, Mikael

AU - Honda, Kenya

AU - Xavier, Ramnik J.

AU - Rasmussen, Simon

AU - Plichta, Damian R.

N1 - Funding Information: The study was funded in part by the Novo Nordisk Foundation (NNF21SA0072102); the Center for Microbiome Informatics and Therapeutics (R.J.X.); NIH grant DK043351 (R.J.X.); and NIH grant DK120485 (R.J.X.). J.J. and S.R. were supported by the Novo Nordisk Foundation (grant NNF14CC0001). K.H., K.A. and Y.A. were supported by Moonshot Research and Development Program (JP22zf0127007) and NeDDTrim (JP21ae0121041) from AMED Japan. K.H. and K.A. were supported by MEXT Japan World Premier International Research Center Initiative (WPI). The EDIA study was supported by NIH grant 1DP3DK094338-01 (M.K.) and by the Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research No. 250114 (M.K.). Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2023/5

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DO - 10.1038/s41564-023-01370-6

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JF - Nature Microbiology

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