Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity

Hannah L Payne, Ranran L French, Christine C Guo, T. D. Barbara Nguyen-Vu, Tiina Manninen, Jennifer L. Raymond

    Research output: Contribution to journalArticleScientificpeer-review

    16 Citations (Scopus)
    25 Downloads (Pure)

    Abstract

    The rate and temporal pattern of neural spiking each have the potential to influence computation. In the cerebellum, it has been hypothesized that the irregularity of interspike intervals in Purkinje cells affects their ability to transmit information to downstream neurons. Accordingly, during oculomotor behavior in mice and rhesus monkeys, mean irregularity of Purkinje cell spiking varied with mean eye velocity. However, moment-to-moment variations revealed a tight correlation between eye velocity and spike rate, with no additional information conveyed by spike irregularity. Moreover, when spike rate and irregularity were independently controlled using optogenetic stimulation, the eye movements elicited were well-described by a linear population rate code with 3–5 ms temporal precision. Biophysical and random-walk models identified biologically realistic parameter ranges that determine whether spike irregularity influences responses downstream. The results demonstrate cerebellar control of movements through a remarkably rapid rate code, with no evidence for an additional contribution of spike irregularity.
    Original languageEnglish
    Article numbere37102
    Number of pages39
    JournaleLIFE
    Volume8
    DOIs
    Publication statusPublished - 2019
    Publication typeA1 Journal article-refereed

    Publication forum classification

    • Publication forum level 2

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