Characteristics of preeclampsia in donor cell gestations

Attina Ervaala; Hannele Laivuori; Mika Gissler; Juha Kere; Katja Kivinen; Anneli Pouta; Eero Kajantie; Seppo Heinonen; Satu Wedenoja

doi:10.1016/j.preghy.2021.12.005

Characteristics of preeclampsia in donor cell gestations

Attina Ervaala, Hannele Laivuori, Mika Gissler, Juha Kere, Katja Kivinen, Anneli Pouta, Eero Kajantie, Seppo Heinonen, Satu Wedenoja

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Abstract

Pregnancies conceived through donor oocytes or sperm show increased risk for preeclampsia. We studied this issue in a preeclampsia case-control cohort (n = 2778), and found overrepresentation of donor cell gestations among women with preeclampsia (14/1627, 0.86%; OR 1.81; 95% CI: 1.07-3.08; P = 0.025) compared to the population data. Moreover, we observed excess of male births from donor cell pregnancies (male-to-female ratio 2.5 vs. 0.97; OR 2.57; 95% CI 1.02-6.36; P = 0.043). Maternal age (36.7 vs. 30.2; P < 0.0001) and preterm deliveries (64% vs. 38%; P = 0.046) distinguished donor cell gestations from other pregnancies with preeclampsia. These results support foreign fetal antigens as modulators of preeclampsia.

Original language	English
Pages (from-to)	59-61
Number of pages	3
Journal	PREGNANCY HYPERTENSION
Volume	27
Early online date	11 Dec 2021
DOIs	https://doi.org/10.1016/j.preghy.2021.12.005
Publication status	Published - Mar 2022
Publication type	A1 Journal article-refereed

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1-s2.0-S2210778921005559-mainFinal published version, 328 KBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202201041071Licence: CC BY

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title = "Characteristics of preeclampsia in donor cell gestations",

abstract = "Pregnancies conceived through donor oocytes or sperm show increased risk for preeclampsia. We studied this issue in a preeclampsia case-control cohort (n = 2778), and found overrepresentation of donor cell gestations among women with preeclampsia (14/1627, 0.86%; OR 1.81; 95% CI: 1.07-3.08; P = 0.025) compared to the population data. Moreover, we observed excess of male births from donor cell pregnancies (male-to-female ratio 2.5 vs. 0.97; OR 2.57; 95% CI 1.02-6.36; P = 0.043). Maternal age (36.7 vs. 30.2; P < 0.0001) and preterm deliveries (64% vs. 38%; P = 0.046) distinguished donor cell gestations from other pregnancies with preeclampsia. These results support foreign fetal antigens as modulators of preeclampsia.",

author = "Attina Ervaala and Hannele Laivuori and Mika Gissler and Juha Kere and Katja Kivinen and Anneli Pouta and Eero Kajantie and Seppo Heinonen and Satu Wedenoja",

year = "2022",

month = mar,

doi = "10.1016/j.preghy.2021.12.005",

language = "English",

volume = "27",

pages = "59--61",

journal = "PREGNANCY HYPERTENSION",

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TY - JOUR

T1 - Characteristics of preeclampsia in donor cell gestations

AU - Ervaala, Attina

AU - Laivuori, Hannele

AU - Gissler, Mika

AU - Kere, Juha

AU - Kivinen, Katja

AU - Pouta, Anneli

AU - Kajantie, Eero

AU - Heinonen, Seppo

AU - Wedenoja, Satu

PY - 2022/3

Y1 - 2022/3

N2 - Pregnancies conceived through donor oocytes or sperm show increased risk for preeclampsia. We studied this issue in a preeclampsia case-control cohort (n = 2778), and found overrepresentation of donor cell gestations among women with preeclampsia (14/1627, 0.86%; OR 1.81; 95% CI: 1.07-3.08; P = 0.025) compared to the population data. Moreover, we observed excess of male births from donor cell pregnancies (male-to-female ratio 2.5 vs. 0.97; OR 2.57; 95% CI 1.02-6.36; P = 0.043). Maternal age (36.7 vs. 30.2; P < 0.0001) and preterm deliveries (64% vs. 38%; P = 0.046) distinguished donor cell gestations from other pregnancies with preeclampsia. These results support foreign fetal antigens as modulators of preeclampsia.

AB - Pregnancies conceived through donor oocytes or sperm show increased risk for preeclampsia. We studied this issue in a preeclampsia case-control cohort (n = 2778), and found overrepresentation of donor cell gestations among women with preeclampsia (14/1627, 0.86%; OR 1.81; 95% CI: 1.07-3.08; P = 0.025) compared to the population data. Moreover, we observed excess of male births from donor cell pregnancies (male-to-female ratio 2.5 vs. 0.97; OR 2.57; 95% CI 1.02-6.36; P = 0.043). Maternal age (36.7 vs. 30.2; P < 0.0001) and preterm deliveries (64% vs. 38%; P = 0.046) distinguished donor cell gestations from other pregnancies with preeclampsia. These results support foreign fetal antigens as modulators of preeclampsia.

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DO - 10.1016/j.preghy.2021.12.005

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JO - PREGNANCY HYPERTENSION

JF - PREGNANCY HYPERTENSION

SN - 2210-7789

ER -

Characteristics of preeclampsia in donor cell gestations

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