Chlorate inhibits tyrosine sulfation of human type III procollagen without affecting its secretion or processing

Arja Jukkola, Juha Risteli, Leila Risteli

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)

Abstract

Sodium chlorate, a potent inhibitor of sulfation reactions, completely inhibits the formation of tyrosine-O-sulfate in type III procollagen in human fibroblasts, when used in concentrations that do not affect the incorporation of radioactive amino acids into protein. The unsulfated type III procollagen is secreted into the medium at a rate comparable to those of sulfated type III procollagen and type I procollagen, which normally does not undergo sulfation. The enzymatic cleavage of the aminoterminal propeptide of type III procollagen is incomplete in fibroblast cultures, irrespective of the sulfation status of the protein. © 1990.
Original languageEnglish
Pages (from-to)264-269
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume170
Issue number1
DOIs
Publication statusPublished - 1990
Externally publishedYes
Publication typeA1 Journal article-refereed

Fingerprint

Dive into the research topics of 'Chlorate inhibits tyrosine sulfation of human type III procollagen without affecting its secretion or processing'. Together they form a unique fingerprint.

Cite this