Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery

Oommen P. Varghese; Jianping Liu; Karthi Sundaram; Jöns Hilborn; Oommen Podiyan Oommen

doi:10.1039/c6bm00335d

Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery

Oommen P. Varghese, Jianping Liu, Karthi Sundaram, Jöns Hilborn, Oommen Podiyan Oommen

Research output: Contribution to journal › Article › Scientific › peer-review

20 Citations (Scopus)

Abstract

Glycosaminoglycan derived nanoparticles are a promising delivery system owing to their unique tumour targeting ability. Exploiting fluorescein for inducing amphiphilicity in these biopolymers provides inherent imaging and drug stabilization capabilities by π-π stacking interactions with aromatic antineoplastic agents. This offers a versatile and highly customizable nanocarrier with narrow size distribution and high drug loading efficiency (80%) with sustained drug release.

Original language	English
Pages (from-to)	1310-1313
Number of pages	4
Journal	Biomaterials Science
Volume	4
Issue number	9
DOIs	https://doi.org/10.1039/c6bm00335d
Publication status	Published - 1 Sep 2016
Publication type	A1 Journal article-refereed

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Materials Science(all)
Biomedical Engineering

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10.1039/c6bm00335d

Cite this

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title = "Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery",

abstract = "Glycosaminoglycan derived nanoparticles are a promising delivery system owing to their unique tumour targeting ability. Exploiting fluorescein for inducing amphiphilicity in these biopolymers provides inherent imaging and drug stabilization capabilities by π-π stacking interactions with aromatic antineoplastic agents. This offers a versatile and highly customizable nanocarrier with narrow size distribution and high drug loading efficiency (80%) with sustained drug release.",

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AU - Varghese, Oommen P.

AU - Liu, Jianping

AU - Sundaram, Karthi

AU - Hilborn, Jöns

AU - Podiyan Oommen, Oommen

PY - 2016/9/1

Y1 - 2016/9/1

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AB - Glycosaminoglycan derived nanoparticles are a promising delivery system owing to their unique tumour targeting ability. Exploiting fluorescein for inducing amphiphilicity in these biopolymers provides inherent imaging and drug stabilization capabilities by π-π stacking interactions with aromatic antineoplastic agents. This offers a versatile and highly customizable nanocarrier with narrow size distribution and high drug loading efficiency (80%) with sustained drug release.

U2 - 10.1039/c6bm00335d

DO - 10.1039/c6bm00335d

M3 - Article

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SP - 1310

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JO - Biomaterials Science

JF - Biomaterials Science

SN - 2047-4830

IS - 9

ER -

Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery

Abstract

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ASJC Scopus subject areas

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