Chromatin and epigenetic dysregulation of prostate cancer development, progression, and therapeutic response

Research output: Contribution to journalReview Articlepeer-review

8 Downloads (Pure)

Abstract

The dysregulation of chromatin and epigenetics has been defined as the overarching cancer hallmark. By disrupting transcriptional regulation in normal cells and mediating tumor progression by promoting cancer cell plasticity, this process has the ability to mediate all defined hallmarks of cancer. In this review, we collect and assess evidence on the contribution of chromatin and epigenetic dysregulation in prostate cancer. We highlight important mechanisms leading to prostate carcinogenesis, the emergence of castration-resistance upon treatment with androgen deprivation therapy, and resistance to antiandrogens. We examine in particular the contribution of chromatin structure and epigenetics to cell lineage commitment, which is dysregulated during tumorigenesis, and cell plasticity, which is altered during tumor progression.

Original languageEnglish
Article number3325
JournalCancers
Volume13
Issue number13
DOIs
Publication statusPublished - Jul 2021
Publication typeA2 Review article in a scientific journal

Keywords

  • Androgen receptor signaling inhibitors
  • Castration resistant prostate cancer
  • Chromatin
  • Chromatin regulators alterations
  • Chromatin-associated factors
  • Drug resistance
  • Epigenetics
  • Lineage commitment
  • Lineage plasticity
  • Prostate cancer

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Chromatin and epigenetic dysregulation of prostate cancer development, progression, and therapeutic response'. Together they form a unique fingerprint.

Cite this