Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, FinnGen, Pradeep Natarajan, Akhil Pampana, Sarah E. Graham, Sanni E. Ruotsalainen, James A. Perry, Paul S. de Vries, Jai G. Broome, James P. Pirruccello, Michael C. Honigberg, Krishna Aragam, Brooke Wolford, Jennifer A. Brody, Lucinda Antonacci-Fulton, Moscati Arden, Stella Aslibekyan, Themistocles L. Assimes, Christie M. Ballantyne, Lawrence F. BielakJoshua C. Bis, Brian E. Cade, Ron Do, Harsha Doddapaneni, Leslie S. Emery, Yi Jen Hung, Marguerite R. Irvin, Alyna T. Khan, Leslie Lange, Jiwon Lee, Jukka Partanen, Kimmo Savinainen, Veli Matti Kosma, Johanna Schleutker, Reijo Laaksonen, Arto Mannermaa, Jukka Peltola, Juha Rinne, Airi Jussila, Tarja Laitinen, Hannu Kankaanranta, Annika Auranen, Hannu Uusitalo, Teea Salmi, S. A. Hedman, Jarmo Harju, Tiina Wahlfors, Juha Kononen, Anastasia Shcherban, Hannele Laivuori, Harri Siirtola, Javier Gracia Tabuenca

Research output: Contribution to journalArticleScientificpeer-review


Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10−72), with similar effects for males and females. Chromosome Xq23 lipid-lowering alleles are associated with reduced odds for CHD among 42,545 cases and 591,247 controls (P = 1.7 × 10−4), and reduced odds for diabetes mellitus type 2 among 54,095 cases and 573,885 controls (P = 1.4 × 10−5). Although we observe an association with increased BMI, waist-to-hip ratio adjusted for BMI is reduced, bioimpedance analyses indicate increased gluteofemoral fat, and abdominal MRI analyses indicate reduced visceral adiposity. Co-localization analyses strongly correlate increased CHRDL1 gene expression, particularly in adipose tissue, with reduced concentrations of blood lipids.

Original languageEnglish
Article number2182
JournalNature Communications
Issue number1
Publication statusPublished - Dec 2021
Publication typeA1 Journal article-refereed

Publication forum classification

  • Publication forum level 3

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)


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